Name: Cheza May B.

Baldado Date:
Section: BS Pharmacy III - A

Subject PHARM 309- Clinical Pharmacy 2

Title Inflammatory Bowel Disease: Ulcerative Colitis
Introduction Inflammatory bowel disease (IBD) is a general term for a group of
chronic inflammatory disorders of unknown etiology involving the
gastrointestinal tract. Ulcerative colitis (UC) is an idiopathic
inflammatory bowel disease that occurs more often in industrialized
countries. This disease affects both men and women similarly. The
disease may be acute and chronic with unpredictable relapses and
remissions. Major advances have been made in many aspects of
inflammatory bowel disease, including new information on the
molecular basis of the disease, epidemiological considerations,
immunology and genetics. The clinical and scientific understanding
of ulcerative colitis has been greatly expanded far beyond our
earlier knowledge.
Objective(s) At the end of the activity, the students will be able to:
1. Identify the 3 classification of Ulcerative Colitis
2. Differentiate Ulcerative Colitis from Crohn’s Disease
Procedure/ Answer the following questions to assess what you learned during
Instruction the case presentation.

1. What are the classifications of Ulcerative Colitis?

 Ulcerative proctitis is endoscopically characterized by edema, erythema and loss of
vascular markings. Granularity, friability, and frank ulceration are also seen in more severe
disease.
 Distal or left-sided colitis is found in patients in whom the inflammatory process extends
from the rectum 40 cm. Disease activity does not extend beyond the splenic flexure, and
there is evidence of chronic inflammation and chronic architectural distortion.
 Pancolitis involves the portion of the colon beyond splenic flexure. It is characterized by
hematochezia and diarrhea, and may be accompanied by abdominal pain and cramps,
fever, and/or weight loss with persistent inflammation. Normal haustral markings disappear
with generalized shortening and tubularization of the colon. In severe disease, the mucosa
may be described as nodular with pseudopolyps, a reticular pattern, and discrete ulcer
craters.
2. Identify the type of ulcerative colitis in the diagram.

Distal or left-sided colitis

Pancolitis
 Ulcerative proctitis

2. In a tabular form, differentiate Ulcerative Colitis from Crohn’s Disease.

Crohn’s Disease Ulcerative Colitis

 Rectal bleeding is less common, whereas
in ulcerative colitis, bleeding from the
rectum is much more common.
 Continuous abdominal pain is more
common and perianal problems such as
fistulas, anal sores and skin tags, can
occur.
 People living with ulcerative colitis usually
have intermittent pain coinciding with
bowel movements.
 Perianal issues are uncommon in
ulcerative colitis.