Pharmacology

1. Aspirin and Phenobarbitone are acidic drugs whereas c. Anticholinesterase drugs

diazepam is basic drugs. Which of the following is d. Pilocarpine
false?
a. Aspirin is present mainly in non ionized form in 7. A patient was put on topical drug for open angle
stomach glaucoma. Now he presents with Macular edema and
b. Diazepam is absorbed from small intestine iris pigmentation as shown in images. Which
c. Phenobarbitone is an enzyme inducer and Antiglaucoma drug was used?
increases duration of action of concomitant drug
administered
d. Diazepam after metabolism give rise to active
metabolite

2. Which of the following is correct regarding the

mechanism of action of thyroid hormones T4 and T3
at thyroid hormone receptor?
a. Activate phosphatidyl inositol/DAG/Calcium
cascade
b. Act by increasing cAMP
c. Activate tyrosine kinase enzyme a. Dipivefrine
d. Activate nuclear transcription factor b. Bimatoprost
c. Echothiophate
3. A 32yr old patient had anaphylactic shock and was d. Apraclonidine
give Inj. Adrenaline 1: 1000 by IM route. The actions
of histamine are antagonized by adrenaline. This type 8. A 42year old male patient came with redness and pain
of antagonism is called in right great toe. His uric acid level was 10mg/dl. The
a. Chemical antagonism doctor prescribed a drug for the treatment. Which of
b. Competitive antagonism the following drug is likely to decrease neutrophil
c. Non competitive antagonism recruitment to inflamed tissue?
d. Physiological antagonism a. Colchicine
b. Lesinurad
4. During drug development, NDA (new drug c. Rasburicase
application) filed in office of FDA at what time? d. Febuxostat
a. After completion of pre clinical trial
b. After phase I of clinical trial 9. DOC for treatment of congenital condition (arrow)
c. After phase III of clinical trial shown in the photograph is:
d. After discovery of lead compound

5. An elderly man was brought to the emergency room

after he ingested a large quantity of metoprolol
tablets. Which of the following drug is used an
antidote?
a. Fomepizole
b. Glucagon
c. Naloxone
d. Carnitine

6. A patient 58year old had laryngeal cancer and

undergone neck irradiation. After that she had
decreased salivary secretion and dry mouth. Which of a. Misoprostol
the following drug is avoided in this patient? b. Indomethacin
a. Cevemeline c. Carboprost
b. Glycopyrrolate d. Alprostadil
10. Mr. Swamy aged 75 has HF and on medication like
telmisartan 20mg and metoprolol. He comes to the
OPD with complaints of shortness of breath,
increased pitting ankle edema, and a 1.5kg weight
gain over the last 3 days. He is stable and has no chest
pain. He was started on furosemide. The drugs act by
following mechanism.
a. Carbonic anhydrase inhibitor
b. NaK 2Cl Cotransport inhibitor
c. NaCl transport inhibitor
d. Aldosterone antagonist
11. A 55 year old male patient was having symptoms of
excessive thirst and excessive urine production and
ADH levels were very low. Which of the following
drug will help in above condition of the patient?
a. Hydrochlorthiazide
b. Desmopressin
c. Tolvaptan
d. Terlipressin
12. A 52 year old male patient of heart failure was on a
diuretic therapy. He developed hyperkalemia. when
an Angiotensin Converting Enzyme (ACE) Inhibitor
was combined with this diuretic. Identify the
offending diuretic.
a. Furosemide
b. Indapamide
c. Hydrochlorothiazide
d. Spironolactone
13. Mr. Basu is a 66 years old ischemic heart disease
patient. He is on Tab. Aspirin 150 mg once daily, Tab.
Clopidogrel 75 mg once daily, Tab. Atorvastatin 10
mg, Tab. Isosorbide dinitrate 10 mg SOS and Cap.
Omeprazole 20 mg once daily. What would be the
possible consequence of this?
a. Loss of effect of atorvastatin as omeprazole
antagonizes statins.
b. Loss of efficacy of aspirin as acid is required for its
action.
c. Loss of efficacy of clopidogrel as omeprazole
prevents activation of clopidogrel
d. Less adverse effects as omeprazole reduces
adverse effects of atorvastatin
14. A 45-year-old man had performance anxiety and
migraine headache. Propranolol was used in this
patient. What comorbid condition listed below you
should very cautious, while using propranolol in this
patient
a. Essential tremor
b. Glaucoma
c. Classic/stable angina
d. Diabetes
15. Which one of the following is the most appropriate
drug to use for the patient described in the following
scenario?
a. Captopril (60-year-old woman with diabetic
nephropathy)
b. Nitroprusside (50-year-old man with BP of 140/95
mm Hg)
c. Losartan (29-year-old pregnant woman)
d. Propranolol (40-year-old patient with peripheral
vascular disease)
16. A 28 year old pregnant women in second trimester
came to OPD for routine check-up. Her blood pressure
was found to be 190/110 mmHg and also she
complains of blurring of vision. What is the drug of
choice for her hypertensive emergency condition?
a. Enalapril
b. Labetalol
c. Nitroprusside
d. Chlorthalidone
17. A 45 year old man has myocardial infarction and is
being treated for the same in emergency department.
Now suddenly he develops ventricular tachycardia.
The best drug to treat this arrhythmia is?
a. Digoxin
b. Lignocaine
c. Metoprolol
d. Quinidine
18. A 57-year- old lady came with chief complaints of
fatigue, sluggishness, and gain in weight. She is
sleeping for many hours in a day. She has been taking
T4 since 17 years without any side effects and disease
symptoms of hypothyroidism. Recently she is
diagnosed as arrhythmia and on anti-arrhythmic
drugs. what is the cause of her current condition?
a. Lidocaine
b. Amiodarone
c. Procainamide
d. Verapamil
19. A 48year old man was discharged after recovering
from COVID 19. His d- dimer levels were high, so the
physician decided to put the patient on oral
anticoagulant drug as prophylaxis. Which of the
following oral anticoagulant acts by directly inhibiting
Xa?
a. Rivaroxaban
b. Dabigatran
c. Enoxaparin
d. Heparin
20. A 50 year old male patient complaints of having episodes
of failing to fall asleep. The episodes repeats for 2-3
times for every week since last two weeks. Because of
the episode he sleeps 3 to 4 hours late. On other
occasion he sleeps well with duration of 7 to 8 hours. On
the next day of episode, he feels less concentrated,
lethargic. He doesn’t complaint of frequent nocturnal
awakening, anxiety, disturbance, physical illness. Which
drug is suitable in this condition without producing
sedation on next morning?
a. Diazepam
b. Flunitrazepam
c. Phenobarbitone
d. Zaleplon
21. A 65year old male patient presented with resting
tremor, Bradykinesia, rigidity and was diagnosed as a
case of Parkinsonism. He was started on Levodopa
and carbidopa combination. Which of the following
side effect doesn't reduce on combination?
a. Psychosis
b. Severe vomiting
c. Arrhythmia
d. Postural hypotension
22. A 30 year old male was a chronic alcoholic. He
stopped drinking alcohol and after few days he
started experiencing anxiety, tremors, tachycardia. He
was being treated for the withdrawal symptoms by
benzodiazepines. He was recovering from chronic
alcoholism but started experiencing intense cravings
for alcohol. What could be given as an adjuvant to
prevent relapse?
a. Disulfiram
b. lofexidine
c. Naltrexone
d. Varenicline
23. A 25 yr old 4months pregnant female having juvenile
myoclonic epilepsy on valproate comes to doctor
regarding her treatment. What is the suggestion?
a. Stop valproate immediately and take lamotrigine
b. Continue valproate with drug levels monitoring
c. Add lamotrigine to valproate
d. Discontinue the treatment and reassure
24. A 30 year old male patient was given drug X, as he
had pain in facial nerve distribution area while
chewing and talking. He now presents with Dilutional
Hyponatremia and Hepatotoxicity. Which is the drug
X patient is taking?
a. Phenytoin
b. Sodium valporate
c. Carbamazepine
d. Valproate
27. A person was under depression and was put on
Fluoxetine therapy. Which of the following is likely to
be caused by Fluoxetine therapy?
a. Visual disturbance
b. Constipation
c. Dry mouth
d. Sexual dysfunction
28. A 58-year-old patient is diagnosed with ovarian
cancer and was started on cisplatin but complains of
severe vomiting after 2 days of starting cisplatin.
Which of the following medications would be most
effective to counteract the emesis in this?
a. Droperidol
b. Aprepitant
c. Prochlorperazine
d. Metoclopramide
29. A 24 year old male with a childhood history of asthma
complained of cough, dyspnea, and wheezing after
cleaning the dirt room. His symptoms became so
severe and he came to the emergency room. Physical
examination revealed diaphoresis, dyspnea,
tachycardia, and tachypnea. His respiratory rate was
42 breaths per minute, pulse rate 110bpm, and blood
pressure 132/65 mm Hg. Which of the following drugs
will not be helpful in this emergency situation?
a. Montelukast
b. Inhaled Ipratropium bromide
c. Inhaled salbutamol
d. Intravenous hydrocortisone
30. A 25 year old married female comes to infertility clinic
with high prolactin levels and not conceiving even
after 3 years of marriage. Which of the following drug
is best for this patient?
a. Nafarelin
b. Abarelix
c. Bromocriptine
d. Leuprolide

25. A Patient on antipsychotic therapy for 1 month, 31. A 64-year-old woman with a history of type 2 diabetes
develops a feeling of restlessness, frequent repetitive is diagnosed with covid 19. Which of the following
stereotyped movements and an inability to sit still for medications would be best choice for controlling her
more than a short period of time. which of the diabetes during hospitilisation?
following drug is responsible for this? a. Exenatide
a. Clozapine b. Regular insulin
b. Imipramine c. Nateglinide
c. Haloperidol d. Pioglitazone
d. Fluoxetine
32. A 50 year old male patient has long standing DMT2
26. Husband is taking Imipramine for a phobic anxiety from last 15 years. He has diabetic gastroparesis and
disorder, and his wife is taking chlorpromazine for a presents with abdominal fullness and heartburn.
psychotic disorder. Which of the following adverse Which of the following drugs will you avoid in this
effects is likely to occur in both of these individuals? patient?
a. Excessive salivation a. Glimiperide
b. Pupillary constriction b. Pioglitazone
c. Orthostatic hypotension c. Dapagliflozin
d. Weight loss d. Dulaglutide
33. A 70-year-old male with BPH and an enlarged
prostate continues to have urinary symptoms after an
adequate doasge of tamsulosin. Dutasteride is added
to his therapy to control symptoms. Dutasteride acts
by following mechanism in BPH
a. Aromatase inhibitor
b. 5 alpha reductase inhibitor
c. Androgen receptor blocker
d. Adrenolytic drug
39. Discharged from hospital 1 week ago after open heart
34. Patient was on low dose of drug X from last 10years
for his allergic condition prescribed by a quack. He
comes with blurring of vision and examination of eye
was as shown in image. The drug which is responsible
for above problem seen in image is:
38. A 28-year-old male complains of 3 days of dysuria and
a purulent urethral discharge. You diagnose this to be
a case of gonorrhea. Which of the following is
appropriate treatment?
a. Ceftriaxone IM
b. Penicillin G IM
c. Gentamicin IM
d. Piperacillin/tazobactam IV
surgery. Which of the following regimens is most
appropriate for empiric coverage of MRSA and
Pseudomonas aeruginosa in this patient?
a. Vancomycin + Cefepime + Ciprofloxacin
b. Vancomycin + Cefazolin + Ciprofloxacin
c. Telavancin + Cefepime + Ciprofloxacin
d. Daptomycin + Cefepime + Ciprofloxacin

40. A 25-year-old married female was on OCPs for

contraception from last 2 years. Two weeks ago she
had a positive tuberculosis skin test (PPD test), and a
chest radiograph showed evidence of right upper lobe
infection. Without asking her drug history, she was
started on standard anti mycobacterial therapy. After
one and half month she came to the doctor and told
that her Urine pregnancy test is positive. Which of the
following drug may be the likely reason behind her
UPT being positive, even after taking OCPs?
a. Ethambutol
a. Omalizumab
b. Isoniazid
b. Paracetamol
c. Pyrazinamide
c. Prednisolone
d. Rifampin
d. Montelukast
41. A male patient was diagnosed with sexually
35. A 48-year-old woman is being treated with
transmitted disease and known to be contracted from
tamoxifene for Breast cancer. There is an increased
his sexual partner. His female partner had
risk of her developing:
trichomoniasis. He is an alcoholic and he needs to be
a. Breast cancer
warned regarding unpleasant symptoms if he
b. Uterine cancer
consumes alcohol with drug. Which antimicrobial
c. Osteoporosis
needs above warning communicated to patient
d. Atrophic vaginitis
before starting?
a. Ceftriaxone
36. Which of following drugs act by inhibiting DNA
b. Doxycycline
synthesis?
c. Metronidazole
a. Nitrofurantoin
d. Azithromycin
b. Rifampicin
c. Metronidazole
42. Which one of the following drugs is most suitable in
d. Acyclovir
an immunocompromised patient for treating
rhinocerebral mucormycosis?
37. A 42 year old lady presents with high grade fever,
a. Amphotericin B
chills, vomiting, myalgia, urgency of micturition and
b. Voriconazole
left sided flank pain. Patient is diagnosed with UTI and
c. Fluconazole
the culture and sensitivity isolated Escherichia coli,
d. Clotrimazole
which is sensitive to fluoroquinolones. Which of the
following drugs should not be used?
a. Ciprofloxacin
b. Ofloxacin
c. Levofloxacin
d. Moxifloxacin
43. A 36year female patient came with running nose,
fever, myalgia and headache from last 7 days. She
comes to fever clinic with difficulty in breathing and
cough, her SpO2 is 88%, Temp 101 F, PR- 120bpm and
normal BP. investigations of patient revealed RTPCR
confirmed COVID 19 Infection, chest X ray and CT scan
findings also confirmed the same features of
infection. He was started on Remdesivir IV and the
drug acts by following mechanism?
a. Neuraminidase inhibition
b. RNA dependent RNA polymerase inhibition
c. Protease inhibition
d. Importin channel inhibition
44. A resident doctor developed needle prick injury while
taking blood sample of HIV positive symptomatic
patient. Which of the following regimen is best for
post exposure prophylaxis of HIV for this doctor?
a. Zidovudine + Lamivudine
b. Tenofovir + lamivudine + Dolutegravir
c. Zidovudine + Lamivudine + Nevirapine
d. Zidovudine + Stavudine + Nevirapine
45. A 60 year old male patient comes to OPD with
lipodystrophy. On taking drug history, he told that he
is taking drugs for his HIV infection and drugs are
zidovudine, lamivudine and lopinavir/Ritonavir.
Which of the following drug is used in the treatment
of his lipodystrophy?
a. Ibalizumab
b. Cobicistat
c. Crofelemer
d. Tesamorelin
49. A 23-year-old female underwent kidney
transplantation. After 8 days, she suffered acute
humoral rejection. She was successfully managed
with tacrolimus and 1 more drug which suppressed B
and T lymphocytes. Drug which target both B and T
lymphocytes via inhibiting de novo synthesis of
purines is?
a. Cyclophosphamide
b. Mycophenolate mofetil
c. Methotrexate
d. Prednisone
50. A 69 year old male came to the Rheumatology
department, with the diagnosis of rheumatoid
arthritis and is on treatment with NSAIDS and weekly
methotrexate. Patient has a history of myocardial
infarction two years back. He comes to OPD with
gastrointestinal disturbance and dyspepsia after
taking drugs for relieving pain in the joints. Which of
the following is the best treatment option for this
patient?
a. Reduce the dose of the drugs given to relieve the
pain in the joints
b. Proton pump inhibitors (PPIs) should be given
along with NSAIDS
c. Selective COX- II inhibitors can be considered to
reduce the joint pain
d. Antacids should be given to reduce the
gastrointestinal symptoms

46. A 56-year old male is having fever and chills. He

develops Plasmodium vivax malaria and treated for
the same. Now he complains of severe fatigue, back
pain, and darkened urine. Which one of the following
anti malarial drugs used in treatment could have
caused his symptoms?
a. Pyrimethamine
b. Artemisinin
c. Doxycycline
d. Primaquine

47. A 40 year male patient was on chemotherapy for Non

Hodgkin lymphoma. His total leucocytes count is now
2000cells/mm3. Which of the following drug is
effective in this condition?
a. Filgrastim
b. Oprelvekin
c. Epoetin alpha
d. Amifostine

48. Which of the following chemotherapeutic drugs

inhibits the polymerization of microtubules but is not
associated with causing bone marrow suppression?
a. Cyclophosphamide
b. Cisplatin
c. 5-Fluorouracil
d. Vincristine