Lymphocyte Development

With Prof. Peter J. Delves

Medicina 201910, medicina201910@outlook.com

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 Recognition of Antigens by the Immune System
Major
T cell receptor Antibody
Receptor PRR Histocompatibility
(TCR) (BCR)
Complex (MHC)
Cell surface,
Cell surface,
Location cytoplasmic, Cell surface Cell surface
secreted
secreted

Each MHC variant

Highly peptide- Highly antigen
Recognition PAMPs/DAMPs can bind many
MHC specific specific
different peptides

Protein diversity
10’s-100’s ~12 for classical MHC Millions Millions
in an individual

Each protein Each protein Genetic Genetic

individually individually recombination recombination
Genes
encoded, encoded, extremely creates diversity creates diversity
low polymorphism polymorphic

Medicina 201910, medicina201910@outlook.com

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