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Vector-Borne Diseases: Dengue
Vector-Borne Diseases: Dengue
Dengue has recently been reclassified by the WHO (World Health Organization) due to
issues when applying the old clinical terms ii. The latest recommendations focus on disease
incidence and cases are categorised as dengue, with no symptoms of warning on dengue
and severe cases of it. Severe dengue is characterised as extremely impacted patients with
strong plasma leaking, serious bleeding or organ involvement. The new classification system
stresses that possible signs should be identified early. Latest findings thus show a higher
delicacy with the revised classificationiii. In order to prevent hospitalizations in particular in
hyperendemic environments, early prediction is vital.
While there is no registered dengue vaccine yet, several vaccine potentials have been
created. Live attenuated virus vaccines, live chemistry, inactivated virus, live recombinant,
DNA, or sub-unit vaccines are all used iv. Live viral vaccinations were carried out in clinical
trials, but issues occured, such as uneven immunogenicity among four tetravalent
formulations and viral involvement among the four serotypes.