Biopharmacy practical

fourth stage
Lab1
Biopharmaceutics and pharmacokinetics
 Biopharmaceutics
Biopharmaceutics: is the science that examine the interrela onship
of the physicochemical proper es of the drug,the dosage form in
which the drug is given, and the rout of administra on ,and the rate
and extent of systemic absorb on.
Biopharmacy involves factors that influence :
1. The stability of the drug(ac ve ingredient) within the drug product.
2. The release of the drug from drug product.
3. The rate of dissolu on\release of the drug at the absorp on site.
4. The systemic absorp on of the drug.
The study of biopharmaceu cs is based on :
A. Scien fic principles.
B. Experimental methodology.

Studies in biopharmaceu cs use both in-vitro and in-vivo methods.

 in-vitro and in-vivo methods

in-vitro
•In vitro-methods are
procedure employing test
apparatus and equipment without
involving experimental animals or
humans.
in-vivo
•In vivo methods are more
complex studies involving human
subjects or laboratory animals .
•Biopharmaceu cs considers the proper es of the drug and the dosage
form in a physiological environment, the drug s intended therapeu c
use ,and the route of administra on.
•Biopharmaceu cs can be divided into :
1. Pharmacokine cs .
2. Pharmacodynamics.
 Pharmacokinetics
Pharmacokinetics: is the science that deals with drug absorp on,
distribu on, metabolism ,and excre on.
•The study of pharmacokine cs involves both experimental and
theore cal approaches.
The experimental aspects
The experimental aspects involves:
1. Development of biological
sampling techniques.
2. Analy cal methods for the
measurement of drug and
metabolites.
3. Procedures that facilitate data
collec on and manipula on .
The theoretical aspects
The theoretical aspects of
pharmacokine cs involves the
development of pharmacokine c
models that predict drug
disposi on a er drug
administra on
 Pharmacodynamics
Pharmacodynamics: refers to the rela onship between the drug
concentra on at the site of ac on (receptor) and pharmacologic
response, including biochemical and physiologic effects that influence
the interac on of drug with the receptor.
•The interac on of a drug molecule with receptor causes the ini a on
of a sequence of molecular events resul ng in a pharmacologic or toxic
response.