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COLISTIN RESISTANT E. coli HARBOURING mcr-1: AN EMERGING SUPERBUG IN

ECUADOR

Conference Paper · November 2016

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5 authors, including:

David Ortega-Paredes Pedro Miguel Barba

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Universidad Técnica del Norte
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Edie Gabriel Molina Cuasapaz Christian Vinueza

Universidad Técnica de Cotopaxi (UTC) Central University of Ecuador
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 COLISTIN RESISTANT E. coli HARBOURING mcr-1: AN EMERGING SUPERBUG IN
ECUADOR
Ortega-Paredes, David1; Barba, Pedro1; Molina-Cuasapaz, Gabriel2; Vinueza Christian3; Zurita, Jeannete1.
1Unidad de Investigaciones en Biomedicina, Zurita&Zurita Laboratorios, Av. de la Prensa N49-221 y
Manuel Valdiviezo, Quito, Ecuador. Email: daortegap@gmail.com.
2 Unidad Productiva Agropecuaria LyJ, Quito, Ecuador.
3 Unidad de Investigación en Enfermedades Transmitidas por Alimentos y Resistencia a los
Antimicrobianos (UNIETAR) de la Facultad de Veterinaria, Universidad Central del Ecuador, Quito,
Ecuador

Colistin resistant Enterobacteriaceae (CRE) is increasingly reported worldwide, overall after the
identification of transferable resistance mediated by MCR-1 and MCR-2 phosphoethanolamine
transferases. Despite its importance, the epidemiology and the mechanisms related to this sort of
Multi-Drug-Resistant (MDR) strains remain unknown. Particularly, in developing countries where
limited resources lead a significant lack in the surveillance data. Additionally, CRE bacteria have
been registered in clinical isolates as well in environmental sources especially related with food
animal production, revealing a complex epidemiology dynamics that highlights the importance of
One Health view of the problem. Because of the scarce data about CRE in Ecuador, the aim of this
study was to evaluate the prevalence of E. coli harboring mcr-1 gene in clinical, food animalsand
environment isolates. We evaluate 3091 E. coli clinical isolates, 111 E. coli BLEE and 70 E. coli
AmpC from poultry and 124 E. coli from an Agricultural Production Unit (APU) for the presence of
mcr-1 gene. The highest prevalence of colistin resistance was registered in poultry isolates, followed
by APU and clinical isolates. Low prevalence (<4.5%) of E. coli harbouring mcr-1 gene was detected
in all populations and all E. coli was MDR. In agreement with other studies, mcr-1 gene was most
prevalent in samples from food animals and environment suggesting that the transference of colistin
resistance to clinics is already in process. But, we have the chance to tackle its dispersion andlimit
the impact of these strains on the human health.
Palabras Caves: mcr-1, Escherichia coli, colistin resistance, clinical, food animals, environment.

AUTOR: David Ortega

TIPO DE PRESENTACION: Oral

TOPICO: Biomedicina

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