28 06.

2 Lndornal heermend
Long rcaven (uelen

uimory amile Phynenoholesbrlemi-7yeI

Narmall Ralpronce onge ohetoioo
Choleilon Tohl: 150- 200 1g
/dl
D cholodenot &o 120 9/
HD oholotorol:mol: 30-60my/04
demal35-75m9/o
ShardAmeen Guuen
Clowilhcalien d ijuiks:
huy coe cloigpiel nlo Gour yuo
Sionple kiriod
uacyglycouk /Neuhal dot
haw
Comypecund dipid
hoaelijuiols B)Nen-hasgralpidks
(Cerilaunamg, OGycocyAAga&iruöks
heoyheuc acu
OVabogongycoophaohlcls ti Cowlnerbk
CConemiole mono/OneN
iKecihun
Cphoyhalieylokelin tGolesioley
Wopholun (1D Canglionolao
hehalily
tharalonmin Cgkobeide +NANA
uPiorghatolylsennu.
Yon nillegen Saulyhattol
gy coroheryoide
(Pweghalillinenb 6ulhalaol
Ceru&wA
hecyhaltiad gycow nlyrbalid
ODnydeboidl
Cordo&jur
glyces
n) amalogen houng don9 0)ulpuhatd
gangiosi

( MaoAlymt otnelogen
() Pheylocghungao0 (yvluyoonyelun
 Deriveol ipils
Foty osda, ucob, jooTaglomduno
wko Tuen, orrn doickoo
d Kinuo Commloned to ahoncemendo
Poutie &ipidy Aipnypda
Prologlordin:
Kocol dhemenve
omel qoenl rologtonlly adlne aletonces
pwwnl aloit i cale i u
o n oloueol Gpm 20C Cydic sawat
yoily ociolot aneic acle
They ore horituod arto PoA, PGR, PG PrE
PCF, PCH,PI
Brickeical otens
O Feet en Cardio0Culon yom
otoln ceyrteizgcl y Lrthsth&im a
Yocoolicolar andiolb risliET
0gugali en
Dgaur oeponilen lollolo .PTanpoy to
d wall, nnailoil
PeI2 Cau hvrombus
domalon
Whrembonan rtooluctol by yealelcts
Yopocciuclon qvwndu
lolelel 0gagaior
Mecl en Oroy +tor
Pak APmulalo ailows mto
PGF ued den twianunootion o
qrgnamoy
Tmduein lolrou coesling folnorhun
o

Pa 2H ndueol
pho plod
labon heemeyrhag
Ldody
anae gees ano oloe eteret
 9Ecol on Rasjinclosy 7Toil.
VGE-conbuelon oneonohialmosh onuoch
Pnk-olet ronolooliiladot yQto on
E4co on Tommurily Jnflamnal or
o y D, >qvwdeuce ailommalion d
Cimoieomg Coyellary 7tncabrly
O woluces dt TBcull funchsy
dcep Vomo ting cadlanc
y VilmY Ovheel -o gvooltecol alTUa6l
ongivy
H c o Crastio on tTial dract.
Andestanol onolili
Johllory lect n gedun sioion od
Metabelic eAlob:
aE oya,caleiun vmo&rlizalon

93la Oiolalien c 4aty cooido

The gowndepp on Hovohord o
Leeilaly yeolecl fon cOmpkell o riolallont
aaty acibl Afte onv ounel ofounmelal
Aego cly loAaurid onl
Juilh 2 Colom kordsgenwob d Ta Nould
Lundpnge am t e wo ction o
wnbkto Joly aco c comyelely oi lord
otycciol Fotly oaf Co (Tdiokia
ASTP Apl PPi
alocy Coh
M
CCaloplam
NIilochendual orerang Carndu
7anmnorlUi.
iloendiol eidi
alty 00y Co
Se 1 Aklolohyoranon
Sleyy
FAD-Likud
Co A
FDH(.5Ai)
Cohuypwginane Tnans A Emwyl CA
Sten 2:
HypUralicn
Eny
Auyolnlone
Emeul CoA +HO
L-(3-hyolwryacy C
Ston3: -4nyobrwny oncy NDt
NADDendert CoA olbyonaenad NADH4H'25
AD
Dihpbogeran 3-Kdoteyl Co
Ste4 Taiolore CoA-SH.
CRiag AcyCoA +Aedtyk CoA
fwhercyele
stey 1,2, TOA (1OA
awgabeo c 2ela- oniolaten ATPytule)
olmilic acil( 16) oeeols 7tyelu of Aelo
So, l g uA o &maie cub
odtalon
Eyey inotecule oocoyl (oA 6oheno accty Con.
AM TA 91Ys 10
ondleculto ofATP.
onuoliged
acolye CoA x10 80 JTP
=

7FADH x 1:5 a5 ATY

7NADH 25 t75 A7P
G 7ecs lolal lo&AT

Net yiold 108-2 106TP

 oboteroR Zaoey7hoi
ayattese
1Acll Aceloac Acloacey -CA
CoANeelbacdyCop

yCoA
Stor 1Acol CoA
CoA Stoy HMG CoAcnpka
CoA
Sela-Ayobte ry&eh -oneliglgaudary os
CRat amilng)3tq3 NADPH12CHMG-
9HMGa-CoArieoluclas VADPH-12
2NADPt

Mevakrnali (G
SAopyA T
Kinon ADP
5-1heryhomoualonn:LE
SAlep4 Kihaa +ATP
5-Hy eptecyrhoonevalornael6)
Aen4C Kinane TP
3hatyo5-uonhermho mUwolo
SAen4DDeconayb tATP C60)
Jsonenleny qry wgrhoyrhob(
S Ain 5-ATomerae
DAmetdylally yriohora
STen 5-B Tramginan 1onenWn rH
Granyt iyno hotpallioc
S/tn b-CTramfenalk Tco nenleryk
PP T opoaha"
Famasyk qtophetmhd fs)
+amenA
2PP
Ston 6raodoe9uakenaYyf0

Squoleno &No nu ole

Son 6-bCeyclase
ane NioC ( 30e)
(27c mola 7p Stin 7A
Zaymono 7
rm

Klone kolie:
Yumry eelbni boolies Aetbacdall
s.Ccoolar kilene dedio: B-duyobwny ulyra
acdo

elegenesas CSte : Conolensolior)

cely& CoA +Auly CoA CSu0cty Aostoandy.
CAyMork
CoA-SH
HMG-(Ammitae C
Sayroouo
STepn 2HMG CoA
Bela-byolro ng- deta-
cmdhyl gutaryl oA
Stsp:3: 2y HMG-OA -Lpe:|
Non engymalie.
dnorlansous. -AuloncdTa +AoylA
NADS Sn4:Reolucli
NAE owgero
Ston5 Spendoneo choehupbren Kalyi
duco-loylali er)
Kelolysio:
liligpd ky Lilnahureie TirnL
Heonl munb y Urok CoHen vekon
dlono dsi
Tran a okelelak muooke y
oh can ols y
to bloi eduo
u
allonli
arT ourioll ewntes ef 0
dodandat plaoro
SancciylCoA oloante
Then oolo ocoly Co ino -0Ndoner oi
 Laven Endnabenale es:
Acelye CoA Frueao
acdo

Koleno bor Klens (eoliu 7boown

Kdene
Cabt acd
pk
boolurn Unin
 Sphuingpljiokre Aipitesreye ltont
Emagme olypol Aruol
hocumlating Salerl featoo.
uchr'sDarcon 3ek-gluuonidve yeo-opt Horaien adull torli guenai,
3lyp enoiOdeialt fhenahntenomie rl.
nena
Niemam okDnkav hngomplvt, inaomel oSevene CNS dam MeNdol suoldouon rurrahi yeremoady

3.Knalle 3Ceukolylryk Pelo gulabaitov,Cralbekcoubrorolde Sevche menlal olardaforonco hmylin aiCNS,

Cyokoo ooli m ahbmatlor
eneraliged
a d s ola galbolastkve CangirlelCM)onlal polardal, hgalomegadolskldalprmi duesoal
ooom ce, Cony iool cy dhNna Llepavons
5aclsylcoronclooBela qaltacloselre LaokbvylcoramileMaunly CNS veteule endrtholal ceyram alfebod
6-Faluy's olicoe lo-godastnik| heordoumulilen o deidney otonal tluwe, Doath y 5y,
na Linkuol nhorln
Meachremale ohlnhclole oulo-galaclo cumuloion on not AM, Neuwwolageo defed,
ulyrcala Cereoraiole c y m eyNoai qrlic Gpay, Iemyelnalion
keukodyveyy
8 Ta SocAcolicoeHeraaninèloA ICenglibrndr)1 n ,000Kbm moCME
merlo! ulardaaien chorny uoleyol
9Scnoko'soditarHeroaminédare CGalolersiolo owologtonk onlot,Monbl ardhlo
Commen deatwre ud Orage
«olinco acumulollol,
o
nl gdungsLyuol
olh oytors yud colg nalena holad.
al0rouas
nemal,ananly
on Bm
ngym odkoiny as