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Review of Ayurvedic Drugs Acting On Hypothyroidism: Tarun Sharma, Malvika, Monu Gupta, Sumit Nathani
Review of Ayurvedic Drugs Acting On Hypothyroidism: Tarun Sharma, Malvika, Monu Gupta, Sumit Nathani
ABSTRACT
Thyroid problems are among the most common endocrine disorders presently seen
worldwide. Hypothyroidism results when the thyroid gland fails to produce enough of the
thyroid hormone, due to structural or functional impairment that significantly impairs its out-
put of hormones, this leads to the hypo metabolic state of hypothyroidism. It is estimated to
affect between 3.8-4.6% of the general population. The prevalence of primary hypothyroid-
ism is 1:100, but increases to 5:100. The female-male ratio is approximately 6:1. There is no
direct reference of thyroid in Ayurvedic classics, but Galganda and Gandmala have been fre-
quently used in these classics. According to Charaka presentation of multiple Granthi around
the neck is called Gandmala and single swelling on the Parshava of the neck is Galganda. So
Galganda and Gandmala can be co-related with hypothyroidism. The incidence of hypothy-
roidism is increasing day by day, and there is increasing demand to treat the disease through
the Ayurvedic system of medicine, as it is completely natural and safe. The root cause of hy-
pothyroidism is disequilibrium of tridosha. In this article effort is made to review some Ayur-
vedic herbs for correction of imbalance in tridosha and flawed function of the thyroid gland.
Keywords: Hypothyroidism, Galganda, Gandamala, Ayurvedic herbs.
INTRODUCTION
Thyroid problems are among the dine-containing chemicals. Because they
most common endocrine disorders present- are the only iodine containing hormones in
ly seen worldwide. About 1 to 2% of the the body, an adequate iodine intake is nec-
adult population is known to suffer from essary for the optimum functioning of the
thyroid disorders.1 According to the World thyroid gland. Doctors recommend about
Health Assembly report, about 1.5 billion 150 mg/day of iodine for normal thyroid
persons in more than 110 countries are function; less than 50 mg/day for a long
threatened with thyroid disorders. World period may cause goiter.3
Health Organization (WHO) estimation Hypothyroidism generally de-
also indicates that about 200 million peo- scribes an under-active thyroid that does
ple have goiter, although most of the goi- not produce enough thyroid hormones
ters are small and subclinical. causing an overall decrease in physical and
Thyroid is one of the earliest endo- mental activity. The disease is more preva-
crine glands to build up2.It is an endocrine lent in females around 6-8 times, between
gland located in the neck below the thyroid 40-50 years.4 Hypothyroidism can result
cartilage (which forms the laryngeal prom- from a defect anywhere in the hypothalam-
inence, or "Adam's apple"). It acts by pro- ic-pituitary-thyroid axis, either insufficient
ducing thyroid hormones, the principal TSH from the pituitary or insufficient
ones being triiodothyronine (T3) TRH from the hypothalamus. In the vast
and thyroxine (T4). Both T4 and T3 are io- majority of cases, it is primary hypothy-
Tarun Sharma et al: Review Of Ayurvedic Drugs Acting On Hypothyroidism
may be prone for the development of Here brief description is given of some
Galaganda.14 important plants which are frequently used
From the above descriptions it is in management of hypothyroidism in pre-
tempting to associate Galaganda with goi- sent era:-
ter (abnormal swelling of the thyroid (1) KANCHANARA:
gland) where thyroid functions may or Latin Name - Bauhinia variegata Linn
may not be compromised. But hypothy- Family- Caesalpiniaceae
roidism is not just a localized disease. It Rasa- Kashaya Guna- Ruksha, Laghu
has many symptoms related to many sys- Virya- Sheeta Vipaka- Katu Kar-
tems of the body. Thus it is probably inac- ma- kapha-Pittahara Useful part-
curate to draw a parallel between hypothy- Bark
roidism and Galaganda. Kanchnara is considered as a drug
Planning of treatment: of choice for Granthi vikara and
'Vikaranamakusalo na jihriyat Galaganda.18External application of kan-
kadachana Nahi sarva vikaranam namo- chanara bark is done in Gandmala. Fresh
toasti dhrivasthitih'15 - bark of kanchanara is grinded with tandu-
Ayurveda doesn't emphasize the exact lodaka and mix with shunthi and used in-
nomenclature of the diseases; rather it in- ternally.19It has a balancing activity on the
sists on diagnosis of the constitutional sta- thyroxin production, increasing any defi-
tus of the disease as mentioned in Chara- cient production and decreasing any ex-
ka. cess. It also clears swellings in the neck
Based on Ayurvedic principles, the follow- and goitre. It is a specific herb for swollen
ing are the main treatments for hypothy- lymph nodes, cervical adenitis, scrophular-
roidism. ia or swollen glands in general.
1. Genetical and hereditary defects come Water-soluble fraction of total alcoholic
under Adibala Pravritta Vyadhis16, so no extract of Bauhinia variegata Linn at a
treatment is suggested. dose of 2 g/kg was fed to Neomercazole
2. Iodine deficiency is the main common (150 mg/kg)-induced hypothyroidic rats (n
cause for hypothyroidism. So 'Sarvadha = 12 in each group) for 20 days. The ex-
sarva bhavanam samanyam vriddhikara- periment resulted in enhanced thyroid
nam'17 applies here. function as evidenced by increased thy-
3. Auto immunity is another common roidal weight (p < 0.001), I131 uptake and
cause, so immuno modulatory drugs are decreased serum cholesterol (p < 0.05 for
recommended here. both), and active thyroidal histology20
4. If there is functional loss of thyroid Bark extract of Bauhinia purpurea
tissue, or functional defects, thyroid stimu- Linn. at 2.5 mg/kg orally administered to
latory drugs are beneficial. female mice (n = 7 in each group) signifi-
'Samprapti vighatana' is one of the cantly increased serum T3 and T4 concen-
main principles of treatment. Whatever trations (p < 0.001 for both) after 20 days
may be the aetiology of the disease, it re- of treatment21
sults in under-active condition of the thy- (2) ASHWAGANDHA:
roid gland and ultimately the slowing Latin Name- Withania somnifera Linn
down of the body's metabolism. So the Dunal Family- Solonaceae
treatment should aim to stimulate the thy-
roid gland.
Taila, which is prepared by Nirgundi sva- 1. Pocock, G. and Richards, C.D., The
rasa and paste of Langali root, is used for thyroid gland, in Human Physiology:
Nasya in treatment of Gandamala.38 The Basis of Medicine, Oxford Univer-
DISCUSSION sity Press, New York, 1999, p. 212.
Hypothyroidism is common disor- 2. Yash pal manjul, Surendra k. Sharma
der now a days. Many modern medicinal editors, API Text book of medicine,
therapies and medicines are available for published by the association of physi-
the treatment of this disease but these are cians of India, 7th edition, 2003,
not devoid of side effects and the re- pg.1051.
occurrence rate is also high. It is very im- 3. Ganong, W.F., The thyroid gland, in
portant to show an interest in indigenous Review of Medical physiology, 7th ed.,
system of medicine and traditional herbal Appleton and Lange, Norwalk, CT,
remedies which are regarded as quite safe 1995, p. 295.
with no side effects and are cost effective. 4. Yash pal manjul, Surendra k. Sharma
Hypothyroidism is often correlated editors, published by the association of
with galganda mentioned in Ayurvedic physicians of India, 7th edition, 2003,
literature. Treatment often includes herbs pg.1057.
like Kanchnara, Shigru, Varuna, Apa- 5. Davidson's principles and practice of
marga, Brahmi, Jalakumbhi, Ashwagan- medicine, Churchill Livingston, 17th
dha. These herbs have also been tested in edition, London. 1995.
various experimental models and proved 6. Yash pal manjul, Surendra k. Sharma
efficacious. But still the mainstay for the editors, published by the association of
Ayurvedic treatment of Hypothyroidism is physicians of India, 7th edition, 2003,
samprapti vighatan (breaking of patho- pg.1052-1053.
genesis) of the disease and Lakshana 7. Yash pal manjul, Surendra k. Sharma
pratyanik (symptomatic treatment). These editors, published by the association of
Ayurvedic herbs not only provide relief in physicians of India, 7th edition, 2003,
various symptoms but also directly alter pg.1058 –1059.
the secretions of the different hormones 8. Agnivesha, Charaka, Dridhabala,
involved in pathogenesis of the disease and Charaka Samhita, Sutra-sthana, Maha-
stimulate the normal functioning of thyroid roga Adhyaya, 20/17, edited by Dr.
gland. Brahmanand tripathi, Chaukhamba
CONCLUSION surbharati prakashana Varanasi, reprint
From this review we conclude that 2008, pg. 395.
hypothyroidism can be very well managed 9. Sushruta, Sushruta Samhita, Shareera-
with Ayurvedic medicines, depending upon sthana, Garbhavyakarana sharira
the symptoms, and careful selection of Adhyaya, 4/4, edited by kaviraaj Am-
drugs to be made. Herbal extracts possess bikadutta shastri, Chaukhamba San-
natural antioxidants, which not only help skrit sansthan Varanasi, reprint 2010,
in curing the diseases, but also improve the pg. 37.
body’s defense system. So Ayurveda based 10. Sushruta, Sushruta Samhita, Nidana-
herbal remedies should be preferred for the sthana, Granthi-apachi-arbuda-
management of Hypothyroidism. galaganda Adhyaya, 11/31, edited by
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CORRESPONDING AUTHOR
Dr. Tarun Sharma
Email: tarunsharma1286@gmail.com