Name of the drug General action Mechanism or action Indication Contraindication Side effects/adverse Nursing responsibilities

and caution effects

Generic name: Administered Methylergometrine acts
Methylergometrine after delivery of directly on the smooth
the placenta. It muscle of the uterus and
Brand name: minimizes the increases the tone, rate,
Methergine risk of and amplitude of rhythmic
postpartal contractions through
Dosage: hemorrhage. binding and the resultant
0.2 ml IM antagonism of the
dopamine D1 receptor.
Thus, it induces a rapid
and sustained tetanic
uterotonic effect which
shortens the third stage of
labor and reduces blood
loss.
Routine Contraindications  GI: Nausea, Assessment & Drug Effects
management vomiting (especial
after delivery of Hypersensitivity ly with IV doses).   Monitor vital signs (particularly BP)
placenta and for to ergot  CV: Severe and uterine response during and after
postpartum preparations; to hypertensive parenteral administration of
atony, induce labor; use episodes, methylergonovine until partum period
subinvolution, prior to delivery bradycardia.  is stabilized (about 1–2 h).
and hemorrhage. of placenta;  Body as a  Notify physician if BP suddenly
With full threatened Whole: Allergic increases or if there are frequent
obstetric spontaneous phenomena periods of uterine relaxation.
supervision, may abortion; including shock,
be used during prolonged use; ergotism. Patient & Family Education
second stage of uterine sepsis;
labor. hypertension;  Report severe cramping for increased
toxemia; bleeding.
lactation.  Report any of the following: Cold or
numb fingers or toes, nausea or
vomiting, chest or muscle pain.
 Do not breast feed while taking this
drug
Name of the General action Mechanism or action Indication Contraindication Side effects/adverse Nursing responsibilities
drug and caution effects
Generic name: Effectively Carboprost is a synthetic To induce Contraindications  Body as a Whole: Assessment & Drug Effects
CARBOPROST stimulates uterine prostaglandin. It binds abortion between Fever, flushing,
contraction and is the prostaglandin E2 13th and 20th Acute pelvic chills, cough,  Monitor uterine contractions and
Brand name: used to induce receptor, causing week of inflammatory headache, pain observe and report excessive vaginal
Hemabate abortion over a myometrial contractions, pregnancy, as disease; active (muscles, joints, bleeding and cramping pain. Save all
wide range of casuing the induction of calculated from cardiac, lower abdomen, clots and tissue for physician
Dosage: gestational age. labour or the expulsion first day of last pulmonary, renal, eyes), hiccups, inspection and laboratory analysis.
250 mg IM Useful in of the placenta. menstrual period. or hepatic breast tenderness.  Check vital signs at regular intervals.
treatment of Prostaglandins occur Also for refractory disease;  GI: Nausea, Carboprost-induced febrile reaction
postpartum naturally in the body and postpartum pregnancy diarrhea, vomiting. occurs in more than 10% of patients
hemorrhage due act at several sites in the bleeding. (category D); and must be differentiated from
to uterine atony body including the womb lactation. endometritis, which occurs around
unresponsive to (uterus). They act on the third day after abortion.
usual measures. muscles of the womb, Cautious Use
causing them to contract. Patient & Family Education
History of
asthma; adrenal  Report promptly onset of bleeding,
disease; anemia; foul-smelling discharge, abdominal
hypotension; pain, or fever.
hypertension;  Since ovulation may reoccur as early
diabetes mellitus; as 2 wk post-abortion, you may wish
epilepsy; history to consider appropriate
of uterine contraception.
surgery; cervical  Do not breast feed while taking this
stenosis; fibroids. drug
Name of the General action Mechanism or action Indication Contraindication Side effects/adverse Nursing responsibilities
drug and caution effects
Generic name: Tazobactam is an The beta-lactamase Treatment of moderate Contraindication  CNS: Headache, Assessment & Drug Effects
inhibitor of a inhibitors are to severe appendicitis, s insomnia, fever.
piperacillin- wide variety of recognized as uncomplicated and  Obtain history of hypersensitivity
tazobactam bacterial beta– substrates for the beta- complicated skin and Hypersensitivity  GI: Diarrhea, to penicillins, cephalosporins, or
lactamases. It has lactamases produced skin structure to piperacillin, constipation, other drugs prior to administration.
little antibacterial by bacteria. This allows infections, endometritis, tazobactam, nausea, vomiting,
 Lab tests: C&S prior to first dose of
Brand name: activity itself; the actual beta-lactams pelvic inflammatory penicillins, dyspepsia,
the drug; start drug pending
however, in to attack the bacterial disease, or nosocomial cephalosporins, pseudomembranou
Zosyn results. Monitor hematologic status
combination with cell wall by binding to or community-acquired or beta- s colitis.
piperacillin, it penicillin binding pneumonia caused by with prolonged therapy (Hct and
Dosage: lactamase
extends the proteins piperacillin-resistant,  Skin: Rash, pruritus, Hgb, CBC with differential and
inhibitors such as
4.5 gmIV every spectrum of piperacillin/tazobactam- hypersensitivity platelet count).
clavulanic acid
6hrs after bacteria that are susceptible, beta- reactions.
and sulbactam.  Monitor patient carefully during
negative susceptible to lactamase-producing
the first 30 min after initiation of
skintest piperacillin. Two- bacteria. Cautious Use
drug combination the infusion for signs of
has antibiotic Kidney failure; hypersensitivity (see Appendix F).
activity against an pregnancy
Patient & Family Education
extremely broad (category B),
spectrum of lactation.  Report rash, itching, or other signs
gram-positive, of hypersensitivity immediately.
.
gram-negative,
and anaerobic  Report loose stools or diarrhea as
bacteria. these may indicate
pseudomembranous colitis.

 Do not breast feed while taking this

drug without consulting physician.