Studies indicate that Miro may be involved in PD.

[7] In neurons, Miro interacts

with two key proteins involved in PD, PINK1 and Parkin.[6] Following depolarization
of the mitochondria, PINK1 phosphorylates Miro at multiple sites, including S156,
and Parkin ubiquitinates Miro, targeting it for proteasomal degradation.[6][7]
Degradation of Miro then halts mitochondrial transport.[6]

Though the Rho GTPase family is closely associated with cancer progression, there
are few studies demonstrating such association with the atypical Miro proteins.[10]