Reconstitution and Stability of IntravenousMedications

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Reconstitution and Stability of Intravenous Medications

Generic name Brand Initial Diluent Diluent Final Stability of Vials After
Name Strength Volume concentration Reconstitution
Room Temp Refrigerator
Acyclovir Zovirax 250mg SWFI/NS 10ml 25mg/ml 12hrs * Don't
Lovark 250mg SWFI/NS 10ml 25mg/ml 12hrs Don't
Amoxycillin+ Julmentin 600mg SWFI/NS 10ml 60mg/ml 4hrs 8hrs
Clavulanic
Acid

Ampicillin Epicocillin 500mg SWFI 5ml 100mg/ml 4hrs 4hrs


Epicocillin 1gm SWFI 10ml 100mg/ml 4hrs 4hrs
Epicocillin 500mg NS 5ml 100mg/ml 24hrs 24hrs
Epicocillin 1gm NS 10ml 100mg/ml 24hrs 24hrs
Cefepime Maxipime 2gm SWFI/NS 10ml 200mg/ml 24hrs 7days
Maxipime 1gm SWFI/NS 10ml 100mg/ml 24hrs 7days
Ceftazidime Negacef 1gm SWFI/NS 10ml 100mg/ml 24hrs 7days
Fortum 2gm SWFI/NS 9.4ml 200mg/ml 24hrs 7days
Ceftriaxone Triaxone 1gm SWFI/NS 5ml 200mg/ml 24hrs 7days
Rocephine 1gm SWFI/NS 9.6ml 100mg/ml 3days 10days
Enoxirt 1gm SWFI/NS 10ml 100mg/ml 24hrs 7days
Cefuroxime Maxil 750mg SWFI/NS 7ml 100mg/ml 24hrs 10days
Zinoxime 750mg SWFI/NS 7.5ml 100mg/ml 24hrs 48hrs
Cefuzine 750mg SWFI 8ml 100mg/ml 24hrs 48hrs
nt Diluent Final Stability of Vials After
Volume concentration Reconstitution
Room Temp Refrigerat
or
I 5ml 100mg/ml 2hrs 24hrs
I 10ml 100mg/ml 2hrs 24hrs
I 5ml 50mg/ml 24hrs 48hrs
y( 19ml 50mg/ml 24hrs 24hrs
SWFI
y( 20ml 50mg/ml 24hrs 2weeks
I
NS 2ml 50mg/ml 3days 3days
)PFL (
W 100ml 5mg/ml 3hrs 24hrs

I 7.8ml 62.5mg/ml 48hrs


1ml 40mg/ml 6hrs 12hrs

100ml 0.4mg/ml 12hrs


W 100ml 0.4mg/ml 6hrs
Penicillin G Penicillin G .M.U 1 SWFI 10ml 100.000units/m **Used immediately
Penzathine Retarpen 1.2M.U SWFI 5ml 240000units/ml Used immediately
Benzylpenicillin )only i.m(
Piperacillin+ Tazocin 2.25gm SWFI/NS 10ml 200mg/ml 24hrs 48hrs
Tazobactam Tazocin 4.5gm SWFI/NS 20ml 200mg/ml 24hrs 48hrs
Generic name Brand Initial Diluent Diluent Final Stability of Vials After P
Name Strength Volume concentration Reconstitution F
Room Refrigerator L
Temp =
Streptomycin Streptomycin 1gm SWFI 5ml 200mg/ml Used immediately )onlyi.m( Pr
Sulfate ot
Vancomycin Vancolon 500mg SWFI 10ml 50mg/ml 48hrs 14days ec
Meropenem Na Meronem 500mg SWFI/NS 10ml 50mg/ml 8hrs 48hrs t
fr
om light NS=Normal Saline SWFI= Steril Water For Injection

Acyclovir in refrigerator cause precipitate *


Because even at refrigerator temperatures aqueous solutions of penicillin G rapidily disintegrate to form degradation and **
.conversion products

Prepared By: Nasser albalawi

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