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Case Analysis in Patient With Undifferentiated Schizophrenia
Case Analysis in Patient With Undifferentiated Schizophrenia
Presented by:
III-C GROUP 11
I. PERSONAL DATA
SEX : Female
OCCUPATION : None
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III. PSYCHOPATHOLOGY
Schizophrenia is a severe psychotic illness that affects the mood, regulation of emotion,
thought process, behavior, and total personality integrity. Although this is called a psychotic
illness, the person is not continuously psychotic. It is commonly thought of today as more than
The term schizophrenia was first used by E. Bleuler in 1911 to emphasize the schism or
splitting off of the mind between the functions of feeling and thinking. Many people falsely think
of schizophrenia as the splitting of the personality into two parts; the term actually was meant to
describe the disorganization of the thinking and emotional processes. (Psychiatric/ Mental Health
Nursing Giving Emotional Care Third Edition, Murray & Huelskoetter, 1991)
Incidence
Schizophrenia affects around 0.3–0.7% of people at some point in their life, or 24 million
Despite the received wisdom that schizophrenia occurs at similar rates worldwide, its
prevalence varies across the world, within countries, and at the local and neighborhood level. It
disabilities in developed countries. A disability survey made by the National Statistics Office
(NSO) showed it is among the third most common form of disabilities with prevalence rate of 88
cases per 100,000 population. The NSO revealed that the region with the highest prevalence rate
is southern Tagalog at 132.9 cases per 100,000 population, followed by NCR at 130.8 per
These include delusions, hallucinations, and grossly disorganized thinking, speech, and
behavior.
These include flat affect, lack of volition, and social withdrawal or discomfort.
Medication can control the positive symptoms, but frequently the negative symptoms
persist after positive symptoms have abated. The persistence of these negative symptoms over
time presents a major barrier to recovery and improved functioning in the client’s daily life.
and is not influenced by external stimuli. Other features may include extreme negativism,
(of other types) along with disturbances of thought affect, and behavior.
Undifferentiated Schizophrenia
a physical breakdown of mental processes that results in a loss of normal emotional responses.
undifferentiated lacks the paranoid symptoms (sense of persecution) that is part of paranoid
schizophrenia. The onset of this disease process usually starts in young adulthood (late teens or
early twenties). The specific causes are not clearly understood although there is evidence that
genetics, early environment, neurobiology and psychological factors may all be contributing
Risk factors
A. Non- Modifiable
1. Genetics
not in adopted relatives. The risk of schizophrenia in first-degree relatives of persons with
schizophrenia is 10%. If both parents have schizophrenia, the risk of schizophrenia in their child
is 40%. Concordance for schizophrenia is about 10% for dizygotic twins and 40-50% for
monozygotic twins. Children adopted at birth into a family with no history of schizophrenia still
reflect the genetic risk or tendency for schizophrenia, but genetics cannot be the only factor;
identical twins have only a 50% risk even though their genes are 100% identical.
"calcium channel pathway" and the "micro-RNA 137" pathway. The calcium channel pathway
includes the genes CACNA1C and CACNB2. The proteins determined by these genes play an
important part in nerve cell processes. CACNA1C and CACNB2 — both of which are involved
in the balance of calcium in brain cells, are implicated in several of these disorders, and could
provide a potential target for new treatments. The micro-RNA 137 pathway includes the gene
MIR137, a known "regulator of neuronal development," and many other genes are regulated by
it.
Current evidence suggests that there are a multitude of genetic abnormalities involved in
schizophrenia, possibly originating from one or two changes in genetic expression. Scientists are
beginning to discover the ways in which specific genes affect particular brain functions and
cause specific symptoms. Genes that have been studied include the neuregulin-1 gene, the
dopamine. The enzyme is encoded by the COMT gene. COMT is located (along with 47 other
genes) in a fragment of chromosome 22q11 which when deleted results in a complex syndrome,
the psychiatric manifestations of which include schizophrenia and other psychoses. These 2
observations have placed COMT near the top of a rather long list of plausible candidate genes for
schizophrenia.
Neuregulin 1 (NRG1) is a plausible susceptibility gene because of its involvement in
nervous system (CNS) and other neurotransmitter receptor expression, and synaptic plasticity.
Earlier research suggests that schizophrenia is associated with changes in myelin, the
fatty substance or white matter in the brain that coats nerve fibers and is critical for the brain to
function properly. Myelin is formed by a group of central nervous cells called oligodendrocytes,
which are regulated by the gene oligodendrocyte lineage transcription factor 2 (OLIG2). Patients
with schizophrenia are known to have insufficient levels of oligodendrocytes, however the
2. Neuroanatomic Factors
includes enlarged ventricles and asymmetrical hemispheres. Computer Tomography Scan and
Magnetic Resonance Imaging found decrease blood flow to the frontal lobes of people with
schizophrenia. These types of brain abnormalities forecast certain symptoms, like loss of
attention, difficulty with abstract thinking, and the inability to solve problems.
Findings have demonstrated that people with schizophrenia have relatively less brain
tissue and cerebrospinal fluid than other people who do not have schizophrenia; this could
represent a failure in development or a subsequent loss of tissue. CT scans have shown enlarged
ventricles in the brain and cortical atrophy. PET studies suggest that glucose metabolism and
oxygen are diminished in the frontal cortical structures of the brain. The research consistently
shows decreased brain volume and abnormal brain function in the frontal and temporal areas of
persons with schizophrenia. This pathology correlates with the positive signs of schizophrenia
(temporal lobe) such as psychosis and the negative signs (frontal lobe) such as lack of volition or
motivation and anhedomia. It is unknown if these changes in the frontal and temporal lobes are
the result of failure of these areas to develop properly or if a virus, trauma, or immune response
has damaged them. Intrauterine influences such as poor nutrition, tobacco, alcohol, and other
drugs, and stress also are being studied as possible causes of the brain pathology found in people
with schizophrenia.
system with a subsequent decreased brain volume, with reduced regional hippocampus, thalamus
and frontal lobes. Someone with the diagnosis of schizophrenia has a structural change within
the limbic system that often creates impulsivity, aggression, and sexually inappropriate behavior.
B. Partially Modifiable
1. Neurochemical factors
The neuronal networks that transmit information by electrical signals from a nerve cell
through its axon and across the synapse require a complex series of biochemical events; studies
Currently the most prominent neurochemical theories involve dopamine and serotonin.
One prominent theory suggests excess dopamine as a cause. This theory was developed based on
two observations. First, drugs that increase activity in the dopaminergic system, such as
symptoms; in fact, the greater the ability of the drug to block dopamine receptors, the more
schizophrenia. The theory modulates and helps control excess dopamine. Some believe that
antipsychotics such as clozapine (Clozaril) are both dopamine and serotonin antagonists. Drug
studies have shown that clozapine can dramatically reduce psychotic symptoms and ameliorate
Researchers also are exploring the possibility that schizophrenia may have three separate
behavior; and negative symptoms. Investigations show that three syndromes relate to
neurobiologic differences in the brain. It is postulated that schizophrenia has subgroups, which
Dopamine monitors energy levels and controls metabolism and as evident by the manic-like
characteristics of positive symptoms, dopamine can also produce physiological effects similar to
Dopamine also plays a role in cognition, mood, attention, and learning, which accounts
for symptoms like thought disorders (disorganized thinking and thought blocking), movement
such as gamma-aminobutyric acid (GABA), serotonin, and acetylcholine can also account for the
spectrum.
responsible for producing endorphins. Under peak functionality, GABA promotes relaxation,
however abnormalities in its production or distribution can have opposing effects which result in
negative symptoms. Negative symptoms consist primarily of emotional and physical apathy.
Glutamate is the key excitatory neurotransmitter in the brain and plays a primary role in
prefontral cortical function and vital behavioral activities, including memory and learning.
2. Immunovirologic factor
Theories have emerged that exposure to a virus or the body’s immune response to a virus
could alter the brain physiology of people with schizophrenia. Although scientists continue to
Cytokines are chemical messengers between immune cells, mediating inflammatory and
immune responses. Specific cytokines also play a role in signaling the brain to produce
behavioral and neurochemical changes needed in the face of physical or psychological stress to
maintain homeostasis. It is believed that cytokines may have a role in the development of major
1. Life Experiences
The chance of developing schizophrenia has been found to increase with the number of
adverse social factors (e.g. indicators of socioeconomic disadvantage or social exclusion) present
in childhood. Stressful life events generally precede the onset of schizophrenia. A personal or
recent family history of migration is a considerable risk factor for schizophrenia, which has been
linked to psychosocial adversity, social defeat from being an outsider, racial discrimination,
family dysfunction, unemployment and poor housing conditions. Childhood experiences of abuse
or trauma are risk factors for a diagnosis of schizophrenia later in life. Recent large-scale general
population studies indicate the relationship is a causal one, with an increasing risk with
methodological issues require further research. There is some evidence that adversities may lead
to cognitive biases and/or altered dopamine neurotransmission, a process that has been termed
studies of victims of sexual abuse and other traumas have sometimes reported findings similar to
those sometimes found in psychotic patients, such as thinning of the corpus callosum, loss of
2. Family Relationship
Evidence is consistent that negative attitudes from others increase the risk of
controlling attitudes (termed 'high expressed emotion' by researchers). Although family members
and significant others are not held responsible for schizophrenia - the attitudes, behaviors and
interactions of all parties are addressed - unsupportive dysfunctional relationships may also
3. Alcohol
neurotransmitter. While GABA is known primarily for its ability to put you in a relaxed state, it
actually plays a crucial role in regulating many aspects of mood, attention, cognition, and sleep.
GABA deficiency symptoms may involve any of these functions and include depression, anxiety,
and insomnia.
While alcohol doesn’t increase GABA, it does increase the amount pf serotonin and
dopamine released in the brain. Even drinking a little bit of alcohol of serotonin and dopamine in
your brain and stimulate certain reward centers. This is why people feel pleasurable effects when
they drink.
4. Smoking
DSM 5 Criteria
1. Two or more of the following for at least a one-month (or longer) period of time, and
Delusions
Hallucinations
Disorganized speech
1. Impairment in one of the major areas of functioning for a significant period of time
2. Some signs of the disorder must last for a continuous period of at least 6 months. This
six-month period must include at least one month of symptoms (or less if treated) that
meet criterion A (active phase symptoms) and may include periods of residual symptoms.
symptoms
If mood episodes (depressive or manic) have occurred during active phase symptoms,
they have been present for a minority of the total duration of the active and residual
Others:
Some may appear normal in terms of being dressed while some may wear strange or
inappropriate clothing.
Echopraxia – imitate the movements and gestures of someone whom the patient is
observing
o Word salad – jumbled words and phrases that are disconnected or incoherent and
o Clang association – ideas that are related to one another based on sound or
o Stilted language – use of words or phrases that are flowery, excessive and
pompous
of sentence, phrase, word, even when another person change the topic
o Word salad – combination of jumbled words and phrases that are disconnected
Slowed or accelerated speech in rate and volume; may speak in whispers or hushed tones
Latency of response – hesitation before the client responds to questions which may last
30 or 45 seconds and usually indicates the client’s difficulty with cognition or thought
processes
thought blocking
thought insertion
poverty of content (alogia) – lack of any real meaning or substance in what the client says
Delusions
experience delusions (fixed, false beliefs with no basis in reality) in the psychotic phase
of Illness
Depersonalization
Impaired judgment
Impaired insight
Self-concept
Deterioration of self-concept
Low self-esteem
Social isolation
Self-care deficits
Prognosis
Individuals with schizophrenia have more than twice the rate of death than those without
the disorder. Almost half of people with schizophrenia will suffer from a substance-use disorder
(for example, alcohol, marijuana, or other substance) during their lifetime. Research shows that
problems that are associated with schizophrenia (for example, memory problems, and learning
improve work functioning have shown some promise, but more research is needed, particularly
that which focuses on improving how well the person with schizophrenia functions in real-world
constructive involvement from people who have schizophrenia, provides role models for
individuals whose functioning is less stable, and may be accessible in individual and group
settings, in person as well as by telephone or through the Internet. However, further research is
In terms of weight management, more research is needed to explore how to best help
people with schizophrenia retain the weight loss they achieve and even to prevent weight gain in
People with schizophrenia or schizoaffective disorder have a better quality of life if their
A. GENERAL DESCRIPTION
Josan Marie Capili is 31 years old. She is mesomorph, appears clean and neat wearing their
uniform. Her apparent age is congruent with her actual age. She was comfortably sitting
during the interview and maintains good eye contact. Her gait is normal and her back is
slouched when sitting. Her rate of speech is normal, fluent and clear with good articulation
and she displays blunted affect. She responds to questions without any delay.
B. EMOTIONAL STATUS
Her facial expression is not congruent on the way she answers the question, because most
of the time she displays blunted affect, she has a difficulty portraying the correct emotions
relating to the situation. For example, after the movement therapy, when asked how she
felt, the patient answered “masigla at nabuhayan po” but displays a poker face. When the
student nurse asked about her past experiences, blunted affect was noted and when she
asked about her current mood or feelings, the patient claimed that she feels okay and
contented. She smiles at times, but when she is not talking, it seems like she is thinking
The patient stated that she is not experiencing any dreams at all. Problems in thought
content and process are not evident to the client during the examination.
Level of Orientation
The client is oriented with time, place and the person herself. When the student nurse asked
about where she was at the moment, she stated that she is at National Center for Mental
Health, and she was also asked about the date that time and she stated it correctly which she
As for the memory, the client was asked for his immediate, recent, and remote memory.
For the immediate memory, she was asked what therapy was done earlier that day. She said
Occupation therapy which is correct. For the recent memory, she was asked what she ate
this morning. She answered “kumain kami ng pandesal at uminom ng isang basong tubig”.
For the remote memory, she was asked what is reason why her grandmother and grandfather
died. She answered, “Yung grandmother ko namatay dahil sa cancer at yung grandfather ko
naman ay namatay dahil sa sakit na hypertension at diabetic, she also stated the date of their
The digit span test which the client repeat are the following numbers 3, 8, 6, 5, 1, 7, 4,
2,3,8, and after 2 trials she was able to repeat 3, 8, 6, 5, 3, 8 and the rest she wasn’t able to
repeat them because she was not able to recall them. She was also asked to repeat it
backwards and she was able to say the numbers, 8, 3, 2, 6, 8, 3, she was only state 4 digits
correctly. The client is an average level because she stated 6 digits correctly forward and 6
digits backward.
The Serial 7’s test was performed and the client answered immediately and answered it all
correctly which is considered normal. The client was also asked different questions such as:
1. Love
2. Smile
3. Happiness
Answer: “kaligayahan”
4. Angry
Answer: “nagagalit”
5. Crying
6. Sad
Answer: “nalulungkot”
ABSTRACTION
The client was asked to explain the proverb “Nasa Diyos ang awa, nasa tao ang gawa” and
the client’s response is “kahit sobrang dami nating kasalanan sa isat isa, mapapatawad parin
pera at may ID ng taong nakaiwan, ano ang gagawin mo?” The client said “kukunin ko at
She was able to write her full name when she was asked to write on a sheet of blank paper, and
IV. PSYCHOTHERAPIES
who has completed an approved music therapy program. Music therapy is one of the expressive
therapies, consisting of a process in which a music therapist uses music and all of its facets—
physical, emotional, mental, social, aesthetic, and spiritual—to help clients improve their
physical and mental health. It is a type of expressive arts therapy that uses music to improve and
maintain the physical, psychological and social wellbeing of individuals involves a broad range
of activities such as listening to music, singing and playing a musical instrument. Music is used
to improve the quality of a patient’s life. Music therapy helps the patient with both motor and
communication skills. It is also a reduction of pain, loneliness, and stress as well as improved
coloring, or sculpting to help people express themselves artistically and examine the
psychological and emotional undertones in their art. The patient creates using paints, pens,
pencils and many other types of materials to convey emotions that may be difficult painful for
The student nurse asked her and she claimed that she drew their house and the tree beside their
house because she misses their home and she wants to stay in their home already.
Analysis
concentration and reasoning skills. This therapy helped her express her feelings because her
drawing was very specific and she briefly explained that her drawing is all about how she
misses home and how she really wanted to stay on their home already. With regards to the
drawing, it was presented through a simple drawing which signifies that the client is selfish.
Moreover, the client also uses light stroke which means inadequacy. The client also uses green
color for the house which indicates that the client has more controlled behavior which is
evident and observed upon the client throughout the whole encounter. Overall, the client has
2. Occupational Therapy
Occupational therapy is the only profession that helps people across the lifespan to do
the things they want and need to do through the therapeutic use of daily activities (occupations).
Occupational therapy practitioners enable people of all ages to live life to its fullest by helping
them promote health, and prevent—or live better with—injury, illness, or disability. A form of
therapy for those recuperating from physical or mental illness that encourages rehabilitation
In the Occupational Therapy the patient was able to make a design in the cupcake nicely and
neat. She was able to follow instructions and she performed the activity well and organized. She
designed her cupcake with a girl wearing a smiley face using the different colors.
Analysis
The patient was able to successfully perform the activity. She uses mixed colors in the
designing of her cupcake which signifies that the client has higher level of intellectual
functioning. When asked to present her output, she told them that she designed her cupcake with
smiley face which means that the she is happy and she drew a girl on the cupcake symbolizing
her child. Overall, the design of the cupcake showed that she misses her child and she wants to
3. Bibliotherapy
specific texts with the purpose of healing. It uses an individual's relationship to the content of
In the bibliotherapy the patient is able to verbalize his feelings and thoughts in the short
The goal of bibliotherapy is to broaden and deepen the client’s understanding of the
Analysis
understand themselves. It may reduce feelings of isolation that may be felt by people with
problems. After the short story (si langgam at si tipaklong), questions were asked such as:
a. Ano po ang aral na mapupulot ninyo sa istorya? (Dapat magsumikap sa buhay. Never
Based from her interpretation and analysis of the story, the patient was able to
appropriately reflect and relate life with the storyline hence, the patient has clear understanding
clients by promoting self-esteem, awareness and socialization.” Those who facilitate these
create fun and it consists of five structured steps. Remotivation differs from other therapies
because it focuses on the patient’s abilities rather than on their disabilities. The major endeavor
is to discuss and develop the patient’s healthy aspect no matter how repressed they maybe.
In the Remotivation therapy the patient will able to cooperate and listen to the pictures
5. Movement Therapy
support intellectual, emotional, and motor functions of the body. As a form of expressive
therapy, movement therapy looks at the correlation between movement and emotion. The
intervention. In the case of our patient, during the movement therapy, she seems to be lacking
energy and drive to join the activity – all throughout the therapy, even with the effort of the
student nurse to encourage her, she still lacks energy and presents with blunt affect.
Also, when asked how she felt after the therapy, there is incongruence of her facial
expression to her verbal answer because the patient was emotionless while saying that she felt
1. OLANZAPINE
interfering with the binding of dopamine at D1, D2, D3 and D5 receptors, and has a high affinity
for the D4 receptor in the limbic region of the brain. It also acts as an antagonist at α-adrenergic,
histamine H1, cholinergic and other dopaminergic and serotonergic (5-HT2A) receptors. It
produces fewer extrapyramidal reactions and less tardive dyskinesia than standard anti
psychotics. It is believed that many psychotic illnesses are caused by abnormal communication
among nerves in the brain and that by altering communication through neurotransmitters, thus
F. Nursing Responsibilities
severe infection.
4. Explain the action of the drug in a To gain cooperation and compliance in
therapies.
6. Monitor for the adverse and side
of therapy.
drug.
patient.
2. RISPERIDONE
the brain. It may also block histamine receptors, and other neural receptors to improve
schizophrenia
improves alteration in thought to maintain the stability of the client. It also suppresses psychotic
F. Nursing Responsibilities
administration. mistakes.
Observe patient when administering medication. To ensure that the medication is swallowed and
position
Monitor patient’s mental status (orientation, For notable changes in behavior that could
mood, and behavior) and mood before and indicate the emergence or worsening of suicidal
tiredness, or hypotension
Monitor patient for onset of extrapyramidal side To be able to refer to the physician immediately
spasms and twisting motions; pseudo discontinuation may be necessary as ordered and
diaphoresis, hypertension).
Document the procedure done. For legal purposes and to provide information
patient.
Diazepam is a benzodiazepine that exerts anxiolytic, sedative, muscle-relaxant, anticonvulsant
and amnestic effects. Most of these effects are thought to result from a facilitation of the action
of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous
system.