RRL

Chemical Composition and Antibacterial

Activity of the Essential Oil of Centella
asiatica. Growing in South Africa
 o.A OYEDEJI & A.J. ALFOYAN 2011
https://doi.org/10.1080/13880200590928843

https://www.tandfonline.com/doi/abs/10.1080/1388020
0590928843

In South Africa, Centella asiatica. (L.) Urb is used traditionally for the treatment of
various diseases.  This medicinal plant revealed 11 monoterpenoid hydrocarbons
(20.20%), nine oxygenated monoterpenoids (5.46%), 14 sesquiterpenoid
hydrocarbons (68.80%), five oxygenated sesquiterpenoids (3.90%), and one
sulfide sesquiterpenoid (0.76%). α.-Humulene (21.06%), β.-caryophyllene
(19.08%), bicyclogermacrene (11.22%), germacrene B (6.29%), and myrcene
(6.55%) were the predominant constitutes. The essential oil extract exhibited a
broad spectrum of antibacterial activities against Gram-positive (Bacillus subtilis,
Staphylococcus aureus.) and Gram-negative (Escherichia coli, Pseudomonas
aeruginosa, Shigella sonnei.) organisms.

Inhibitory Effect of Varying Concentrations of Leaves’ Extracts of Centella 

Asiatica (Gotu Kola) on Some Microorganisms of Medical Importance 

Dora Imefon Udoh1,*, Naomi Udo Asamudo1, Danladi Ngyan Bala2 and Otung
Enwongo1 

http://pdfmedarticles.com/i/ijcepr.in2.html

The inhibitory concentration of Centella asiatica (Gotu

kola) on some microorganisms of clinical importance was
investigated using standard microbiological methods.
The phytochemical screening revealed the presence of
Alkaloids, Saponins, Tannins, Flavonnoids,
Anthraquinones, Cardiac glycosides and Phlobatannins.
The antimicrobial tests were carried out with ethanolic
and aqueous extracts using agar disc diffusion method.
The higher inhibitory effects of these ethanolic extracts
may be due to some bioactive substances present in the
extracts. The minimum inhibitory concentrations ranged
from 100mg/ml to 500mg/ml for both aqueous and
ethanolic extracts. The results obtained qualify Centella
asiatica to be a medicinal plant that is recommended for
use in the treatment of some diseases and infections.

The Bioavailability Activity of Centella

asiatica
Patchanee Yasurin, Malinee Sriariyanun, Theerawut Phusantisampan Dec 14, 2015
https://doi.org/10.1016/j.indcrop.2013.03.022 https://www.tci-
thaijo.org/index.php/ijast/article/view/67498

Centella asiatica (Bao-bog, Tiger Herbal, Pennywort, Gotu kola) has been announced as one of five
“Thailand Champion Herbal Products (TCHP)” by the Department for Development of Thai
Transitional and Alternative Medicine, Ministry of Public Health. C. asiatica has been investigated for
its bioavailability activity, antimicrobial activity, antioxidant activity, anti-inflammatory activity, wound
healing activity and anticancer activity. C. asiatica contains many types of active compounds:
terpenoids, terpenoids and phenols. Thus, C. asiatica has high potential to be applied in
pharmaceutical, cosmetic and food industries.

Pentacyclic Triterpenoids from the Medicinal

Herb, Centella asiatica (L.) Urban
Jacinda T. James and Ian A. Dubery
doi:10.3390/molecules14103922
https://www.mdpi.com/1420-3049/14/10/3922
june182014
Centella asiatica accumulates large quantities of pentacyclic triterpenoid saponins, collectively known as
centelloids. The biological activity of saponins has been attributed to these characteristics. In planta,
the Centellatriterpenoids or also known as centelloids can be regarded as phytoanticipins due to their
antimicrobial activities and protective role against attempted pathogen infections. Preparations of C.
asiatica are used in traditional and alternative medicine due to the wide spectrum of pharmacological
activities associated with these secondary metabolites.

Antimicrobial and Antifungal Activity of Centella

asiatica (L.)Urban, Umbeliferae

Jagtap NS*, Khadabadi SS, Ghorpade DS, Banarase NB, Naphade SS

(2011)
http://www.indianjournals.com/ijor.aspx?
target=ijor:rjpt&volume=2&issue=2&article=023
 
https://doi.org/10.5897/JMPR11.621

Centella asiatica (Linn.) urban belonging to family Umbeliferae popularly knows as “Brahmi “, is very
useful medicinal plant described by Charaka as an anti-aging plant. An experiment was carried out to
study the antimicrobial activity of petroleum ether, ethanol and water extract of Centella asiatica plant
by agar diffusion method. Zone of inhibition produced by petroleum ether, ethanol and water extract in
dose of 62.5, 125,250,500 and 1000 μg/ml against some selected strains was measured and compared
with standard antibiotics ciprofloxacin (10μg/ml). The present study demonstrated that the ethanolic
extract of Centella asiatica has higher antimicrobial activity than petroleum ether and water extract.