University of Pangasinan

PHINMA Education
Network
College of Health Sciences

Name: BASUEL, Aira Jane S. Date: February 17, 2021

Year/block/group: 2BSN-8 Clinical Instructor: Jennica Irene Edades Petrola
DRUG STUDY

NAME OF DRUG MECHANISM OF CONTRAINDICATIONS SIDE EFFECTS ADVERSE NURSING

ACTION EFFECTS RESPONSIBILTIES

● Acts directly on ● Preexisting Hypotension: ● Dizziness ● Severe rash ● Consider the 10

GENERIC NAME vascular smooth muscle If the blood pressure is ● Flushing ● CNS: trembling, Golden Rights of
Isoxsuprine causes cardiac already low eg, <100 ● Stomach upset nervousness, administering medication
hydrochloride (HCL) stimulation & uterine mmhg systolic, it must be ● Shaking or weakness, ● Asses patient blood
relaxation and thus borne in mind that the nervousness dizziness pressure in lying &
BRAND NAME causing relaxing the administration of ● Fast or irregular ● CV: transient standing as orthostatic
Duvadilan, Vasodilan veins and arteries and isoxsuprine, in most heartbeat palpitations, hypotension is common.
making them wider to instances, bring about a ● Weakness tachycardia, chest ● Observe both mother
CLASSIFICATION increase the blood flow further reduction in the ● Chest pain pain, hypotension, and baby for
● Class of 2 –amino-1- to certain parts of the blood pressure. ● Rash flushing, cardiac hypotension, irregular
phenylethanol derivative body. It is well absorbed ● Prolonged Premature ● Itching or arrhythmias and rapid heartbeat if
agents. from the gastrointestinal Rupture of Membranes: If swelling (face, ● GI: Abdominal isoxsuprine is used to
● Used as peripheral tract (oral); peak plasma fetal membranes are tongue, throat) distress, nausea, delay premature labor.
vasodilators and cerebral concentrations after ruptured or dilation is > 4 ● Trouble breathing vomiting, intestinal ● Monitor for intensity &
activators 1hour excretion: via cm, chances of success are ● Gastrointestinal distention length of uterine
urine (as conjugates); less. In the cases of disturbances ● Maternal contractions and fetal
1.5 hour (elimination prolonged premature ● Decreased pulmonary edema heart sound (FHS)
INDICATION half-life). rupture of membranes, the calcium, glucose ● Hyperglycemia ● Advice patient to make
● Prevent preterm labor ● It is also a vasodilator. possible benefits to be and blood pressure or hypokalemia position changes slowly
● Inhibit uterine It has a strong inhibitory gained from delaying in infants particularly from lying
contractions effect on the muscular emptying of the uterus down to sitting upright
● Treatment of cerebral
and peripheral vascular
disease. Treatment for
certain blood vessel
diseases such as
cerebrovascular
insufficiency (poor blood
flow to the brain),
arteriosclerosis
(hardening of the
arteries), Raynaud’s
phenomeno, Buerger’s
disease and other
conditions involving poor
blood flow in the veins
and arteries.
● This also help to
decrease symptoms such
as cold hands and feet,
numbness, tingling, and
decreased memory or
judgment.
DOSAGE &
FREQUENCY
● For use as vasodilator:
it is given orally in doses
10-20 mg 3 or 4 times a
day.
● Use for Arrest
Premature
Labor: Initially 200-500
mcg/min by IV infusion,
adjusted according to the
patient's response, until
control is achieved.
Once labor has been
arrested IM injections of
10 mg are given every 3-
tissue of the uterus and must be weighed against
blood vessels. the possibility that undue
● Isoxsuprine induces a prolongation of the
direct relaxant action on pregnancy may actually
the smooth muscle increase the maternal and
fibers and enhances fetal hazards.
those effects resulting ● Isoxsuprine should not
from its action on the be used in presence of
sympathetic receptors. hemorrhage or
● Isoxsuprine was contraindicated after recent
shown to inhibit arterial hemorrhage.
prostaglandin synthetase ● Avoid this medicine if
at high serum you are allergic to
concentrations, with low isoxsuprine, bleeding from
concentrations there was an artery, have fast
an increase in the P-G heartbeat or had any recent
synthesis bleeding
● Isoxsuprine should not
be given immediately
postpartum, nor should it
be used for premature labor
if there is infection.
and avoid standing still
as fainting may occur
● Assess other
medications patient may
be taking for
effectiveness and
interactions
● Monitor therapeutic
effectiveness and adverse
reactions at beginning of
treatment and
periodically throughout
treatment. Evaluate
clinical manifestations of
arterial insufficiency.
● Tell the patient to
report or notify the
physician if experiencing
adverse reactions such as
skin rash, palpitation,
flushing etc.
● Advice the mother not
to breastfeed while
taking this drug without
consulting the physician
8 hrs. Prophylaxis may
be continued orally with
30-90 mg daily.

REFERENCES:
● https://www.medicinenet.com/isoxsuprine-oral/article.htm
●https://www.mims.com/philippines/drug/info/duvadilan?type=full#:~:text=Isoxsuprine%20HCl%20is%20a%20%CE%B2,It%20is%20also%20a
%20vasodilator.
● https://www.stlukesonline.org/health-services/health-information/healthwise/2017/06/27/13/09/isoxsuprine