1 groups of drugs. These are also known a5 sulpha g dr, ide group in their structure. Some of sulphonamig amides ile some have anticonvulsant propery Operty basis of several sulphonam diuretic effects wl drugs are the ents contain the rial, some has useful as antibact HISTORICAL DEVELOPMENT Sulphonamide drugs were the 1* antimicrobial drugs which produced revoluti ion Seeane, The 1 sulphonamide was “Prontosil” which was experimented in 1932 by g ‘AG. Prontosil was a bright red azo dye and was active against streptococcal infection; ee ft communication about this discovery was not published until 1935 and after tw, a this drug was patented by Klarer and Fritz Mietzsch. Prontosil had a strong protectiv saad against infection caused by streptococci, blood infections, fever and infections ca ey cocci. Later on, French research team of Ernest Fourneav accidently discovered that nae gets metabolized into two parts, inside the body i.e. one inactive dye portion and ae couse active compound called sulphanilamide. This active molecule a s . . ‘ er ynthesized in 1906 and was widely used in the dye making industry. After some die i drug was available to anyone. g HN C) 2 wpe N=N- S— —_—_ tee) si ee g ulfanilamide (active dr. NH, : + Prontosil Inactive prodrug in

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