W H I T E B O A R D S

Basic Sciences
Foundations
 Congratulations on making it this far; the journey only gets harder from here. But you’ve found
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Dr. Williams?”

• It is: A companion to OnlineMedEd’s free Basic Sciences video lessons and a great place to
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As with everything we do, this book comes from OnlineMedEd’s two steadfast principles:

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videos these whiteboards accompany are free and always will be.

• OME’s PACE learning methodology—reading the notes (and taking your own), watching
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This book is NOT a replacement for PACE. I’ve seen my students try to shortcut, and that’s just
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help you understand what you need to understand when you need to understand it.
Copyright © 2020 by OnlineMedEd
First Edition This book is a companion. It’s not a crutch.

For information about permission to use or reproduce selections It also has a cute cat animation in the lower-left corner. Check it out.
from this book, email help@onlinemeded.org.

ISBN 978-0-9969501-4-5

Published by OnlineMedEd, www.onlinemeded.org

Authored by Dustyn Williams
Produced by Staci Weber

Reviewed and edited by John Andrew, Ryan Colakovic,

Dominique Cross, Dallin Elmer, Nathaniel Foster, Ran Jing, Austin Mahaffey, Dustyn Williams, MD
Kiara Phelps, Nena Saini, Robert Shebiro, Thomas Stovall, Mateusz Tkacz

Printed in the United States of America

Genetic Material and Introduction NOTES

DNA to Protein
IO N
ANSLAT
POST TR
S MOD
OTIDE
REPL ICATION NUCLE URE STEPS
STRUCT OF TRAN
SLAT ION POINT
NS
FORK S
EU TRANGUL MUTATIO
ANS RE
PRO TR GUL PROTEIN
RE

REPLI
CATIO%
N RRNA
100 TRNA AMINO ACID
DNA RNA
TRANSCRIPTION TRANSLATE KINETICS
M SEQUENCE
(AGCT)
RNA
SN
(CODON)
AA
(AGCU) LWB
DNA REPAIR
VARIATION W/I CELL
PRO EU
NUCLEUS + NUCLEUS
+H1
ORGANELLES + ORGANELLES 3
2 4
4

SS DNA NUCLEOSOME -H1 30 NM

10 NM
ARG + OPEN DNA,
LYS HETEROCHROMATIN
PACKAGED EUCHROMATIN
USABLE
UNSTABLE

Nucleic Acids

1. sugar 2c...is there oh? nucleo side nucleo tide

ho c
5 ho c5

4 1 oh 4 1
oh ho c base pc base
3 2 3 2 ?
ho oh ho
ho ? ho ?
ribose deoxyribose
+ base
(rna) (Dna) + base
p + p
2. base 1c - added deaminate methylate
deaminate
p c5 base
nh2 nh2
4 1
51 31
ch3
ho
3 2

p c5 base
dustyn williams
amine=adenine guanine
cytosine uracil thymine
5p 4 1 31 51
51 p 3 2

base ho
purines pyrimidine 5p
2 syll
2 rings “cut”
p base
1 ring
p
3. phosphate base
s-c ho
pc
p c base base
p p p c 31 base
ho 3oh
mono: am 3oh
p ho ?
di: adp
tri: atp p 5

8 © 2020 OnlineMedEd 9
Structure of DNA NOTES

oh

DNA to Protein
31
51 p 5
t a base
base
p chargaff’s totals
15% a=15% t (30%)
p 35% g=35% c (70%)
base base
C g p
h
p 10,000
base base 1000a=1000t (2000) - 1000 a=t x 2=2000

g c
p
4000g=4000c (8000) - 4000 g c x 3 = 12000
14000

p
base a t base hydrogen bond= 2e
p 5

g c 28,000
3
ho
a t
31 51
g c
a t
weak

Intro to DNA and RNA

3’ 5’
Template Dna Pol
DNA Dna : Gcat Template
5’ 3’ Replicating
5’ Replicating 2
Replication
3’ Replicating*
Template 2 5’ L 3’ R
5’ 3’ High-Fidelity Proofreading
3’ 5’
Template Exonuclease
RNA 3’ 5’
5’ 3’ Transcribing Rna Pol
Rna : Gcau
Coding Transcription Template
“Semi” 5’ Transcribing*
3’
Conservative Low-Fidelity 5’ L 3’ R
Coding
Prokaryotic 5’ L 3’ R
ori Lagging Leading
Eukaryotic
3’ 5’ 5’
3’
3’
5’
5’
3’
Centromere

10 © 2020 OnlineMedEd 11
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