Unit 2 Medicinal Chemistry 4th Semester Mcqs

UNIT 2nd
MEDICINAL CHEMISTRY 1 st
MCQs
WITH SOLUTION
TOP 50 QUESTIONS ACCORDING TO PCI
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1. What is the autonomic nervous system?
Part of the central nervous system independent of the will.
The efferent pathway to the viscera (all fibres connecting the CNS to glands,
smooth muscles and heart).
All efferent fibres in the body except those to smooth muscle.
Afferent (sensory) fibres from the bone
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2. What is dendrites?
Present in neurolgial cells.
May contribute to the formation of synapses.
Contain synaptic vesicles.
None of the above

3. The system that controls smooth muscle,
cardiac muscle, and gland activity is the:
Somatic nervous system.
Skeletal division.
Autonomic nervous system.
Sensory nervous system

4. Autonomic nervous system contains
which type of muscle?
Involuntary
Voluntary
Both
None of the above

5. Which statement is correct about
autonomic ganglia?
Are 5 types.
Are the sites of relay of afferent neurons.
Function as distributing centres.
Are located inside the CNS.
Are relay stations for all pregang . fibers passing through them .

6. Which statement is correct about
preganglionic sympathetic nerve fibres?
Are found in somatic nerves (e.g., median & ulnar nerves).
Are present in the short ciliary nerves.
Are non – myelinated.
Are found in the greater splanchnic nerves.

7. The sympathetic and parasympathetic exert functionally
opposite influences an following parameter except_
heart rate
pupil dimetor
atrial refractory
intestinal motility
8. The major post junctional cholinergic receptor is
one of themuscaric type at the following site,
Postganglionic parasympthetic
Adrenal medulla
Autonomic ganglia
Neuromuscular junction
9. The cardiac muscarinic receptors
are of m1 subtype
are of m₂ subtype
selectivity blocked by pirenzepine
functions through P₁P2 →Tp3/DAG pathway

10. Pilocarpine is used for
Glaucoma
urinary retention
paralytic ileus
All of above
11. The longer acting ocular B-blocker is
Timolol
carteolol
Betaxolol
Levobunolol
12. Which one following is non
catecholamine sympathomimetic drug
Adrenaline
Sphedrine
Dopamine
Isoprenaline
13 .The followed is selective a-2
adrenoreceptor antagonist.
Phentolamine
prazolin
Yohimbine
clondine
14 .The following action of adrenaline is
not mediated by B-receptors.
dilation of blood vessels
Dilalion of pupil
Branchodilation
Renin release from kidney

15. Adrenaline is orally inactive because
not absorbed from GIT
Destroyed by gastric HCl
metabolised by liver
taken up by adrenergic nerve endings

16. Noradrenaline is administerd by
subcutaneous injection
intramuscular injection
slow intravenous infusion
all of the above

17. Identify the basic nucleus of the drug
Xanthine
Dihydroxy phenyl
Catechol
Pyrinidine
18. Identify the structure
Adrenaline
Nor-adrenaline
Dopamine
Catechol
19. Adrenaline is injected with local
anesthetic because
Reduces local toxicity of the local anaesthetic.
Reduce systemic toxicity of the local anaesthetic
Shortens duration of local anaesthesia
Make the injection less painfull

20. Non-selective a-adrenergic blocker
produces the following action except
A .Postural hypotension
b. miosis
c. bradycardia
d. inhibition of ejaculation
21. B-adrenergic blocker having B-1 selectivity,
intrinsic sympathomimetic activity and
membranes stabilizing property is
Carvedilol
Acebulolol
Atenlol
Metoprolol
22. Which of the following drug attenuates
(reduce) the antihypertensive action of B-blockers?
Cimetidine
chlorpromazine
indomethacine
imipramine
23. Prefix -lol is used to denote
a-blockers
α-agonist
B-blockers
B-agonist
24. Identify the structure of B-blocker.
Atenlol
metoprolol
propranalol
salbutamol
25. The following disease is worsened by
propranolol
Glaucoma
Raynaud's disease
prostatic hypertrophy
Parkinsonism
26. Labetalol differs from propranolol in that
It has additional of alpha 1 blocking property
It is selective B-1 blocker.
It does not undergo first past metabolism.
All of above
27. Prazosin is effective antihypertensive while non-
selective a-adrenergic blockers are not because
it is only a rally active a blocker
It improves plasma lipid profile
it does not concurrently enhance nor adrenaline release
It improves urine flow in males.

28. Propranolol does not block the following
action of adrenaline
Bronchadilation
Lipolysis
muscle tremor
mydriasis
29. Select the ultra short acting cardio
selective ß-adrenergic blocker
Bisoprolol
Timolol
Sotalol
esmolol
30. Identify the following structure
Iolazoline
Phentolamine
Prazocin
Isoprenaline
31. In the patients of myocardial infraction B-
adrenergic blockers are used with following aims
to reduce the incidence of reinfarction
to prevent cardiac arrythmias
to limit size of infarct
all of the above

32. The bladder and prostatic muscles are
relaxed by
adrenergic a-1 agoinst
adrenergic a-1 antagonist
adrenergic a-2 agoinst
adrenergic a-2 antagonist

33. The drug which produces vasoconstriction
with a adrenergic blocker?
Phenoxybenzamine
Dihydraergotoxine
Ergotamine
Tolazoline
34. Vasoconstrictors should not be used in
neurogenic shock
hemorrhagic shock
secondary shock
hypotension due to spinal anaesthesia

35. Amphetamine potentiates the following
class of drugs:
Diuretics
Neuroleptics
Analgesics
antihypertensives
36. Identify the name of structure:
Salbutamol
Nor-adrenaline
Dopamine
Terbutaline
Nor-adrenaline
Dopamine
Salbutamol
Terbutaline
Salbutamol
Dopamine
Nor-adrenaline
phenylephrine
Tolazoline
Naphazoline
Dopamine
Salbutamol
Naphazoline
Terbutaline
Nor-adrenaline
None of the above

41. Which is direct acting Sympathomimetic
drug?
Option B
Option A
Hydroxyamphetamine
Adrenaline
42. Which is indirect acting Sympathomimetic drug?

43. Equilibrium type a-adrenergic blocking
agents further divided into
Non-selective
a-1 selective
Both
None of the above

44. Alpha-adrenergic blocking agents are also
known as
Adrenergic antagonist
Sympatholytics
Both of the above
None of the above

45. Which is not an examples of a alpha-
adrenergic blocking agents:
Tolazoline
Phentolamine
Prazocin
Neostigmine
46. Which statement is false
B-blockers are used in Arotic aneurysm.
B-blockers are used in cardiovascular disease
B-blockers are used in congestive heart failure in susceptible patients.
B-blockers are used in treatment of pheochromocytoma.

47. Which of the following is mixed antagonist
Labetalol
Carvedilol
Both of the above
None of the above

48. Identify the name of structure
Bisoprolol
Betazolol
Labetelol
Metoprolol
Metoprolol
Esmolol
Carvediolol
Labetelol
Labetelol
Esmolol
Carvediolol
Bisoprolol
Select the Beta Adrenergic Blocker that has
additional alpha 1 blocking, Vasodilators and
antioxidant properties.
Carvedilol
Acebutolol
Celiprolol
metoprolol

Unit 2 Medicinal Chemistry 4th Semester Mcqs

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Unit 2 Medicinal Chemistry 4th Semester Mcqs

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UNIT 2nd

Part of the central nervous system independent of the will.

All efferent fibres in the body except those to smooth muscle.

Afferent (sensory) fibres from the bone

Website for Free Notes :- www.carewellpharma.in

Present in neurolgial cells.

May contribute to the formation of synapses.

Contain synaptic vesicles.

None of the above

Autonomic nervous system.

Sensory nervous system

None of the above

Are the sites of relay of afferent neurons.

Function as distributing centres.

Are located inside the CNS.

Website for Free Notes :- www.carewellpharma.in

Are found in somatic nerves (e.g., median & ulnar nerves).

Are present in the short ciliary nerves.

Are non – myelinated.

Are found in the greater splanchnic nerves.

Website for Free Notes :- www.carewellpharma.in

selectivity blocked by pirenzepine

functions through P₁P2 →Tp3/DAG pathway

Renin release from kidney

not absorbed from GIT

Destroyed by gastric HCl

taken up by adrenergic nerve endings

slow intravenous infusion

all of the above

Reduce systemic toxicity of the local anaesthetic

Shortens duration of local anaesthesia

Make the injection less painfull

It has additional of alpha 1 blocking property

It is selective B-1 blocker.

It does not undergo first past metabolism.

it is only a rally active a blocker

It improves plasma lipid profile

it does not concurrently enhance nor adrenaline release

It improves urine flow in males.

Website for Free Notes :- www.carewellpharma.in

to reduce the incidence of reinfarction

to prevent cardiac arrythmias

to limit size of infarct

all of the above

adrenergic a-1 antagonist

adrenergic a-2 agoinst

adrenergic a-2 antagonist

hypotension due to spinal anaesthesia

None of the above

Website for Free Notes :- www.carewellpharma.in

None of the above

Both of the above

None of the above

B-blockers are used in Arotic aneurysm.

B-blockers are used in cardiovascular disease

B-blockers are used in congestive heart failure in susceptible patients.

B-blockers are used in treatment of pheochromocytoma.

Website for Free Notes :- www.carewellpharma.in

Both of the above

None of the above

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