Activity

Weight Variation Test

No.1

Objectives

Materials Capsules and uncoated tablets of the same lot number 20 each
Forceps to hold the sample
Weighing bottle
Formula
% wt. variation = Actual wt. per capsule x 100
Average weight

% wt.variation =Diff.bet. Actual wt. per tab &ave.wt. x 100

Average Weight

Compounding Procedure

A. Hard capsules
1. Weigh 20 intact capsules individually recording each weight.
2. Add weights of the 20 capsules for each group and find the average weight.
3. From the average weight, determine the percent variation of each of the 20 capsules.
4. The requirements for weight variation are met if each individual weight is within the limit
of 90% and 110% of the average weight.

Note: Refer to the USP for the requirements

B. Uncoated tablets
1. Weigh individually 20 whole uncoated tablets.
2. Add all the weights of the 20 tablets and determine the average weight
3. From the average weight, determine the percentage variation of the 20 tablets.
4. The requirements for weight variation are met if the weights of not more than two of the
tablets differ from the average weight by more than double the percentage.
 Worksheet
Score

No.1 Weight Variation Test

Mary Allyssa Shayne O. Rasgo

Student’s Name Course& Year

SME’s Name Date Performed

Class Schedule Group No.
Objective/s:

Data
A. HARD CAPSULES
 USE THE NET CONTENT VALUES OF THE CAPSULES

CALCULATIONS:

Compute for the Average weight = __0.29673 g___

% wt. variation = Actual weight per capsule- average wt. x 100

Average Weight

Upper limit:____0.326403 ____

Lower limit:__0.267057___

RESULTS:

1. wt.var. = 4.707983689 11. wt.var. = -2.975769218

2. wt.var. = 2.281535403 12. wt.var. = 2.753344792
3. wt.var. = -0.549320931 13. wt.var. = -3.312775924
4. wt.var. = -7.323155731 14. wt.var. = -0.515620261
5. wt.var. = 1.944528696 15. wt.var. = -1.964749099
6. wt.var. = -0.852626967 16. wt.var. = 5.213493749
7. wt.var. = -0.043810872 17. wt.var. = -3.582381289
8. wt.var. = 2.517440097 18. wt.var. = 0.731304553
9. wt.var. = 0.832406565 19. wt.var. = -0.347116908
10. wt.var. = 0.293195835 20. wt.var. = 0.192093823

CONCLUSION/INTERPRETATION:
For hard capsules, since our computed average weight
B. TABLETS

Net weight per tablet:

1.515 6. 496 11. 502 16. 505
2. 495 7. 504 12. 507 17. 514
3. 503 8. 510 13. 522 18. 504
4. 512 9. 513 14. 491 19. 511
5. 498 10. 499 15. 489 20. 503

Total weight of the 20 tablet = 10,093

CALCULATIONS:

Average weight = weight of 20 tablets = 504.65

20

% wt. variations = Diff. bet. Actual wt. per tab &ave. wt. X 100
Average weight
Upper limit: 529.8825
Lower limit: 479.4175
RESULTS:

Tablet No.
1. wt.var. = 2.050926385 11. wt.var. = -0.525116417
2. wt.var. = -1.912216388 12. wt.var. = 0.465669276
3. wt.var. = -0.326959279 13. wt.var. = 3.438026355
4. wt.var. = 1.456454969 14. wt.var. = -2.704844942
5. wt.var. = -1.317744972 15. wt.var. = -3.101159219
6. wt.var. = -1.714059249 16. wt.var. = 0.069354999
7. wt.var. = -0.12880214 17. wt.var. = 1.852769246
8. wt.var. = 1.060140692 18. wt.var. = -0.12880214
9. wt.var. = 1.654612107 19. wt.var. = 1.25829783
10. wt.var. = -1.119587833 20. wt.var. = -0.326959279

CONCLUSION/INTERPRETATION: