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TECHNICAL
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B4.1.1 APPENDIX 1
CLINICAL EVALUATION
The scientific literature assessment
protocol
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TECHNICAL
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Search Results
Data Base: PubMed
Link to search results: ((Radiotherapy) OR (Radiation therapy)) AND (Basal cell carcinoma) - Search Results - PubMed
(nih.gov)
Number of found studies: 113

Search formula:
((Radiotherapy) OR (Radiation therapy)) AND (Basal cell carcinoma)
Additional filters:
Free Full Text; Clinical Trial; Meta-Analysis; Randomized Controlled Trial; Review; Systematic Review; Date range 2000-
2021 yr.

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№ Title
Hypofractionated radiation therapy
1 for basal and squamous cell skin
cancer: A meta-analysis.
Treatments of Primary Basal Cell
Carcinoma of the Skin: A
2 effectiveness and safety of treatments of
Systematic Review and Network
Meta-analysis.
Emerging trends in the treatment of https://pubmed.ncbi.nlm.nih.gov/29407368
3 options for BCC, focusing on the
advanced basal cell carcinoma.
Long-term efficacy and safety of
sonidegib in patients with advanced
basal cell carcinoma: 42-month
4
analysis of the phase II
randomized, double-blind BOLT
study.
Sonidegib and vismodegib in the
treatment of patients with locally
5
advanced basal cell carcinoma: a
joint expert opinion.
Update in the Management of Basal
6
Cell Carcinoma.
Sonidegib: Safety and Efficacy in
7 Treatment of Advanced Basal Cell
Carcinoma.
Keratinocyte Carcinomas: Current
8 Concepts and Future Research
Priorities.
Product Document Ref.
TECHNICAL
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Link Short description (if article met general
criteria)
The article characterizes the cosmetic
outcomes and local recurrence (LR) rates
https://pubmed.ncbi.nlm.nih.gov/28843727
of various hypofractionated radiation
/
therapy (RT) regimens for skin basal and
squamous cell cancers (BCCs/SCCs).
The article evaluates the comparative
https://pubmed.ncbi.nlm.nih.gov/30242379
/
primary BCC in adults.
The article reviews the available treatment
/
treatment of advanced BCC.
https://pubmed.ncbi.nlm.nih.gov/31545507
/
https://pubmed.ncbi.nlm.nih.gov/31990414
/
https://pubmed.ncbi.nlm.nih.gov/32346750
/
https://pubmed.ncbi.nlm.nih.gov/32297221
/
The article evaluates the comparative
https://pubmed.ncbi.nlm.nih.gov/30523023
effectiveness and safety of treatments of
/
keratinocyte carcinomas.
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Link Short description (if article met general

№ Title
criteria)
Ionizing Radiation Exposure and
https://pubmed.ncbi.nlm.nih.gov/26930381
9 Basal Cell Carcinoma
/
Pathogenesis.
The article aimed to comprehensively
Treatments for Basal Cell and collect information on the comparative
https://pubmed.ncbi.nlm.nih.gov/29533571
10 Squamous Cell Carcinoma of the effectiveness and safety of each currently
/
Skin. used therapeutic strategy for both BCC
and SCC.
Mohs Surgery for the Treatment of
https://pubmed.ncbi.nlm.nih.gov/31553552
11 Skin Cancer: A Review of
/
Guidelines [Internet].
The Malassezia genus in skin and https://pubmed.ncbi.nlm.nih.gov/22232373
12
systemic diseases. /
Management of primary skin cancer
https://pubmed.ncbi.nlm.nih.gov/32478867
13 during a pandemic: Multidisciplinary
/
recommendations.
Long-term efficacy and safety of
sonidegib in patients with locally
advanced and metastatic basal cell https://pubmed.ncbi.nlm.nih.gov/28846163
14
carcinoma: 30-month analysis of /
the randomized phase 2 BOLT
study.
The article describes treatment modalities
Nevoid Basal Cell Carcinoma https://pubmed.ncbi.nlm.nih.gov/20301330
15 of Nevoid Basal Cell Carcinoma
Syndrome. /
Syndrome
https://pubmed.ncbi.nlm.nih.gov/28722968
16 Squamous Cell Skin Cancer.
/
Advanced Basal Cell Carcinoma:
https://pubmed.ncbi.nlm.nih.gov/24587976
17 Epidemiology and Therapeutic
/
Innovations.
18 Immunologic Characteristics of https://pubmed.ncbi.nlm.nih.gov/32207669

X-RAY THERAPY SYSTEM
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№ Title
Nonmelanoma Skin Cancers:
Implications for Immunotherapy.
Targeting the Sonic Hedgehog
19 Signaling Pathway: Review of
Smoothened and GLI Inhibitors.
Management of high-risk and
20
advanced basal cell carcinoma.
A systematic review on the use of
https://pubmed.ncbi.nlm.nih.gov/30695972
21 cryotherapy versus other
treatments for basal cell carcinoma.
The Evolution of Care of Cancers of
22 the Head and Neck Region: State
of the Science in 2020.
The plasticity of pancreatic cancer
23 metabolism in tumor progression
and therapeutic resistance.
Ocular basal cell carcinoma: a brief
24 literature review of clinical diagnosis
and treatment.
Differential pharmacology and
25 clinical utility of sonidegib in
advanced basal cell carcinoma.
Exfoliative cytology for diagnosing
26
basal cell carcinoma and other skin
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Link Short description (if article met general
criteria)
/
https://pubmed.ncbi.nlm.nih.gov/26891329
/
The aim of the present work is to review
clinical and pathologic characteristics as
https://pubmed.ncbi.nlm.nih.gov/25643667
well as classical and new treatment
/
options for high-risk, metastatic and
locally advanced BCC.
The objective of the article is to determine
the efficacy and adverse events profile of
cryotherapy for the treatment of basal cell
/
carcinoma compared to other therapeutic
options or non-intervention.
https://pubmed.ncbi.nlm.nih.gov/32545409
/
https://pubmed.ncbi.nlm.nih.gov/29702208
/
https://pubmed.ncbi.nlm.nih.gov/28507440
/
https://pubmed.ncbi.nlm.nih.gov/28182134
/
https://pubmed.ncbi.nlm.nih.gov/30521689
/
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Link Short description (if article met general

№ Title
criteria)
cancers in adults.
Basal cell carcinoma - molecular https://pubmed.ncbi.nlm.nih.gov/22293184
27
biology and potential new therapies. /
Photodynamic therapy in the https://pubmed.ncbi.nlm.nih.gov/23599819
28
treatment of basal cell carcinoma. /
Basal Cell Carcinoma in the Middle
https://pubmed.ncbi.nlm.nih.gov/32784170
29 Ear: A Case Report and Literature
/
Review.
Spotlight on vismodegib in the
treatment of basal cell carcinoma: https://pubmed.ncbi.nlm.nih.gov/28546761
30
an evidence-based review of its /
place in therapy.
https://pubmed.ncbi.nlm.nih.gov/22679179
31 Vismodegib.
/
Characterization and Management
of Hedgehog Pathway Inhibitor-
https://pubmed.ncbi.nlm.nih.gov/27511905
32 Related Adverse Events in Patients
/
with Advanced Basal Cell
Carcinoma.
Vismodegib: the first drug approved
https://pubmed.ncbi.nlm.nih.gov/23525058
33 for advanced and metastatic basal
/
cell carcinoma.
Sonidegib for the Treatment of https://pubmed.ncbi.nlm.nih.gov/33194718
34
Advanced Basal Cell Carcinoma. /
Giant Basal cell carcinoma:
https://pubmed.ncbi.nlm.nih.gov/19596942
35 clinicopathological analysis of 51
/
cases and review of the literature.
Basal Cell Carcinoma of the
https://pubmed.ncbi.nlm.nih.gov/27738570
36 Umbilicus: A Comprehensive
/
Literature Review.
37 Pulsed dye laser in the treatment of https://pubmed.ncbi.nlm.nih.gov/31062722
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№ Title
criteria)
basal cell carcinoma: A single
session versus two sessions - a /
randomized controlled trial.

Usefulness of Photodynamic
Therapy as a Possible Therapeutic https://pubmed.ncbi.nlm.nih.gov/26426005
38
Alternative in the Treatment of /
Basal Cell Carcinoma.
In this review, authors highlight the current
literature and advances in the use of PRT
Palliative radiotherapy for skin https://pubmed.ncbi.nlm.nih.gov/28061538 for patients with the three most commonly
39
malignancies. / encountered forms of skin malignancies:
basal cell carcinoma (BCC), squamous
cell carcinoma (SCC), and melanoma.
Basal cell carcinoma-treatments for https://pubmed.ncbi.nlm.nih.gov/24980564
40
the commonest skin cancer. /
Sonidegib in the Treatment of
https://pubmed.ncbi.nlm.nih.gov/33197438
41 Locally Advanced Basal Cell
/
Carcinoma.
Association study of genetic
variation in DNA repair pathway https://pubmed.ncbi.nlm.nih.gov/28510302
42
genes and risk of basal cell /
carcinoma.
This review aimed to give an overview of
Treatment of keratinocyte
https://pubmed.ncbi.nlm.nih.gov/32030838 the current literature on the best practice
43 carcinoma in elderly patients - a
/ for the treatment of elderly patients with
review of the current literature.
keratinocyte carcinoma.

 Studies in a search result: 113

 Picked studies: 43
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TECHNICAL
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 Studies selected for analysis: 10

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TECHNICAL
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THERAD 100 EVALUATION

Search Results
Data Base: PubMed
Link to search results: ((Radiotherapy) OR (Radiation therapy)) AND ((Squamous cell carcinoma) AND (Skin)) - Search
Results - PubMed (nih.gov)
Number of found studies: 155
Search formula:
((Radiotherapy) OR (Radiation therapy)) AND ((Squamous cell carcinoma) AND (Skin))
Additional filters:
Free Full Text; Clinical Trial; Meta-Analysis; Randomized Controlled Trial; Review; Systematic Review; Date range 2000-
2021 yr.
Previously selected articles were excluded.
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TECHNICAL
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Link Short description (if article met

№ Title
general criteria)
Literature review of existing
Actinic Keratosis and Cutaneous https://pubmed.ncbi.nlm.nih.gov/32048593
1 sources describing SCC
Squamous Cell Carcinoma. /
treatment
Squamous cell carcinoma of the skin (non- https://pubmed.ncbi.nlm.nih.gov/25137222
2
metastatic). /
Hypofractionated radiation therapy for
https://pubmed.ncbi.nlm.nih.gov/28843727
3 basal and squamous cell skin cancer: A
/
meta-analysis.
Drug therapy of advanced cutaneous
https://pubmed.ncbi.nlm.nih.gov/28151757
4 squamous cell carcinoma: is there any
/
evidence?
The object of this article is to
assess the effects of treatments
Interventions for non-metastatic squamous for non-metastatic invasive
cell carcinoma of the skin: systematic https://pubmed.ncbi.nlm.nih.gov/24191270 squamous cell carcinoma (SCC)
5
review and pooled analysis of observational / of the skin using evidence from
studies. observational studies, given the
paucity of evidence from
randomised controlled trials.
Psoriasis and cancer. An Australian/New https://pubmed.ncbi.nlm.nih.gov/29992535
6
Zealand narrative. /
Update of the Management of Cutaneous https://pubmed.ncbi.nlm.nih.gov/32346744
7
Squamous-cell Carcinoma. /
8 Multidisciplinary management of locally https://pubmed.ncbi.nlm.nih.gov/32905333 Authors provide recommendations
advanced and metastatic cutaneous / for patient classification and staging
squamous cell carcinoma. based on current guidelines,
direction for determining patient
eligibility for surgery and rt, and an
overview of the available systemic
treatment options for advanced cscc
and of the benefits of a
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Link Short description (if article met

№ Title
general criteria)
multidisciplinary approach to patient
management.
Actinic keratoses: review of clinical, https://pubmed.ncbi.nlm.nih.gov/31789244
9
dermoscopic, and therapeutic aspects. /
https://pubmed.ncbi.nlm.nih.gov/28722968
10 Squamous Cell Skin Cancer.
/
The Role of the Immune System in https://pubmed.ncbi.nlm.nih.gov/31022866
11
Cutaneous Squamous Cell Carcinoma. /
Keratinocyte Carcinomas: Current https://pubmed.ncbi.nlm.nih.gov/30523023
12
Concepts and Future Research Priorities. /
Treatments for Basal Cell and Squamous https://pubmed.ncbi.nlm.nih.gov/29533571
13
Cell Carcinoma of the Skin. /
Phase III Randomized Study of Induction
Chemotherapy Followed by Definitive
Radiotherapy + Cetuximab Versus
https://pubmed.ncbi.nlm.nih.gov/32629446
14 Chemoradiotherapy in Squamous Cell
/
Carcinoma of Head and Neck: The
INTERCEPTOR-GONO Study
(NCT00999700).
Management of primary skin cancer during
https://pubmed.ncbi.nlm.nih.gov/32478867
15 a pandemic: Multidisciplinary
/
recommendations.
Mohs Surgery for the Treatment of Skin https://pubmed.ncbi.nlm.nih.gov/31553552
16
Cancer: A Review of Guidelines. /
Cisplatin and fluorouracil with or without
panitumumab in patients with recurrent or
https://pubmed.ncbi.nlm.nih.gov/23746666
17 metastatic squamous-cell carcinoma of the
/
head and neck (SPECTRUM): an open-
label phase 3 randomised trial.
CASE (CemiplimAb-rwlc Survivorship and https://pubmed.ncbi.nlm.nih.gov/31951149
18
Epidemiology) study in advanced /
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№ Title
general criteria)
cutaneous squamous cell carcinoma.

A multicenter phase II trial of paclitaxel,

carboplatin, and cetuximab followed by
https://pubmed.ncbi.nlm.nih.gov/31943834
19 chemoradiotherapy in patients with
/
unresectable locally advanced squamous
cell carcinoma of the head and neck.
Immunologic Characteristics of
https://pubmed.ncbi.nlm.nih.gov/32207669
20 Nonmelanoma Skin Cancers: Implications
/
for Immunotherapy.
Outcomes of Cutaneous Squamous Cell
Carcinoma in the Head and Neck Region https://pubmed.ncbi.nlm.nih.gov/30844021
21
With Regional Lymph Node Metastasis: A /
Systematic Review and Meta-analysis.
The Evolution of Care of Cancers of the
https://pubmed.ncbi.nlm.nih.gov/32545409
22 Head and Neck Region: State of the
/
Science in 2020.
Neoadjuvant paclitaxel, ifosfamide, and
https://pubmed.ncbi.nlm.nih.gov/20625118
23 cisplatin chemotherapy for metastatic
/
penile cancer: a phase II study.
Authors describe two cases of
upper limb squamous cell
Is radiation therapy as a primary treatment carcinoma treated with
modality for squamous cell carcinoma of https://pubmed.ncbi.nlm.nih.gov/32815685 radiotherapy, review the literature
24
the hand the best choice? Case series and / on radiotherapy as a primary
review of the literature. treatment modality, and discuss
the specific difficulties treating
SCC in the hand.
Squamous cell carcinoma of the skin (non- https://pubmed.ncbi.nlm.nih.gov/21733203
25
metastatic). /
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general criteria)
Inherited epidermolysis bullosa and
https://pubmed.ncbi.nlm.nih.gov/27544590
26 squamous cell carcinoma: a systematic
/
review of 117 cases.
Comparative efficacy and safety of
radiotherapy/cetuximab versus
radiotherapy/chemotherapy for locally https://pubmed.ncbi.nlm.nih.gov/33343720
27
advanced head and neck squamous cell /
carcinoma patients: a systematic review of
published, primarily non-randomized, data.
Developments in the treatment of locally
https://pubmed.ncbi.nlm.nih.gov/24857130
28 advanced and metastatic squamous cell
/
carcinoma of the skin: a rising unmet need.
Randomized, self-controlled, prospective
assessment of the efficacy of mometasone
https://pubmed.ncbi.nlm.nih.gov/31876704
29 furoate local application in reducing acute
/
radiation dermatitis in patients with head
and neck squamous cell carcinomas.
Exfoliative cytology for diagnosing basal
https://pubmed.ncbi.nlm.nih.gov/30521689
30 cell carcinoma and other skin cancers in
/
adults.
Panitumumab plus radiotherapy versus
chemoradiotherapy in patients with
unresected, locally advanced squamous- https://pubmed.ncbi.nlm.nih.gov/25596659
31
cell carcinoma of the head and neck /
(CONCERT-2): a randomised, controlled,
open-label phase 2 trial.
Phase II study of cetuximab plus
concomitant boost radiotherapy in
https://pubmed.ncbi.nlm.nih.gov/23479383
32 Japanese patients with locally advanced
/
squamous cell carcinoma of the head and
neck.
33 Phase 1 study of erlotinib plus radiation https://pubmed.ncbi.nlm.nih.gov/23182701
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therapy in patients with advanced
/
cutaneous squamous cell carcinoma.

Consensus guidelines for the management

of radiation dermatitis and coexisting acne-
like rash in patients receiving radiotherapy https://pubmed.ncbi.nlm.nih.gov/17785763
34
plus EGFR inhibitors for the treatment of /
squamous cell carcinoma of the head and
neck.
Vemurafenib in patients with
BRAF(V600E)-positive metastatic or
unresectable papillary thyroid cancer https://pubmed.ncbi.nlm.nih.gov/27460442
35
refractory to radioactive iodine: a non- /
randomised, multicentre, open-label, phase
2 trial.
Palliative radiotherapy for skin https://pubmed.ncbi.nlm.nih.gov/28061538
36
malignancies. /
Current concepts in management of oral https://pubmed.ncbi.nlm.nih.gov/18674952
37
cancer--surgery. /
VITAL phase 2 study: Upfront 5-
fluorouracil, mitomycin-C, panitumumab
https://pubmed.ncbi.nlm.nih.gov/31851776
38 and radiotherapy treatment in
/
nonmetastatic squamous cell carcinomas
of the anal canal (GEMCAD 09-02).
mTHPC-mediated photodynamic therapy https://pubmed.ncbi.nlm.nih.gov/15185355
39
for early oral squamous cell carcinoma. /
Alternative Options for Skin Cancer
https://pubmed.ncbi.nlm.nih.gov/32962182
40 Therapy via Regulation of AKT and Related
/
Signaling Pathways.
41 Prognostic factors and the role of adjuvant https://pubmed.ncbi.nlm.nih.gov/25993217
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radiation therapy in non-melanoma skin
/
cancer of the head and neck.

Purpose of the article is To

compare cosmesis and local
recurrence (LR) of definitive
Skin CanceR Brachytherapy vs External
https://pubmed.ncbi.nlm.nih.gov/29370985 external beam radiation therapy
42 beam radiation therapy (SCRiBE) meta-
/ (EBRT) vs brachytherapy (BT)
analysis.
for indolent basal cell carcinoma
(BCC) and squamous cell
carcinoma (SCC) of the skin.
Early postoperative paclitaxel followed by
concurrent paclitaxel and cisplatin with
radiation therapy for patients with resected https://pubmed.ncbi.nlm.nih.gov/19720915
43
high-risk head and neck squamous cell /
carcinoma: report of the phase II trial
RTOG 0024.
Secondary skin neoplasms in patients after
https://pubmed.ncbi.nlm.nih.gov/33064381
44 autologous and allogeneic hematopoietic
/
stem cell transplantation procedures.
Induction therapy with cetuximab plus
docetaxel, cisplatin, and 5-fluorouracil
(ETPF) in patients with resectable https://pubmed.ncbi.nlm.nih.gov/25684313
45
nonmetastatic stage III or IV squamous cell /
carcinoma of the oropharynx. A GERCOR
phase II ECHO-07 study.
A phase II study of concomitant https://pubmed.ncbi.nlm.nih.gov/12622520
46
hyperfractionated radiation therapy and /
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double dose intra-arterial cisplatin for
squamous cell carcinoma of the head and
neck.
Photodynamic therapy of feline cutaneous
squamous cell carcinoma using a newly
https://pubmed.ncbi.nlm.nih.gov/17708398
47 developed liposomal photosensitizer:
/
preliminary results concerning drug safety
and efficacy.
The objective of this study was to
compare the cosmesis and
recurrence rates of conventional
Surgical excision, Mohs micrographic
excision (CE), Mohs
surgery, external-beam radiotherapy, or
https://pubmed.ncbi.nlm.nih.gov/31355928 micrographic surgery (MMS),
48 brachytherapy for indolent skin cancer: An
/ external-beam radiation therapy
international meta-analysis of 58 studies
(EBRT), or brachytherapy (BT),
with 21,000 patients.
for basal cell carcinoma and
squamous cell carcinoma of the
skin.
Research gaps in the management and
https://pubmed.ncbi.nlm.nih.gov/29086412
49 prevention of cutaneous squamous cell
/
carcinoma in organ transplant recipients.
Radiotherapy related skin toxicity
(RAREST-01): Mepitel film versus standard https://pubmed.ncbi.nlm.nih.gov/29454311
50
care in patients with locally advanced head- /
and-neck cancer.
High-risk cutaneous squamous cell https://pubmed.ncbi.nlm.nih.gov/22261673
51
carcinoma. /
Management of BCC and SCC of the Head https://pubmed.ncbi.nlm.nih.gov/27556662
52
and Neck. /
Advances in the Understanding of Skin https://pubmed.ncbi.nlm.nih.gov/30999681
53
Cancer: Ultraviolet Radiation, Mutations, /
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and Antisense Oligonucleotides as
Anticancer Drugs.
Induction chemotherapy and cetuximab for
locally advanced squamous cell carcinoma https://pubmed.ncbi.nlm.nih.gov/19917840
54
of the head and neck: results from a phase /
II prospective trial.
Daylight Photodynamic Therapy: An https://pubmed.ncbi.nlm.nih.gov/33171665
55
Update. /

Grouped skin metastases from laryngeal

https://pubmed.ncbi.nlm.nih.gov/14996400
56 squamous cell carcinoma and overview of
/
similar cases.
A phase II study of gefitinib for aggressive
https://pubmed.ncbi.nlm.nih.gov/22261807
57 cutaneous squamous cell carcinoma of the
/
head and neck.
58 Basal cell carcinoma. https://pubmed.ncbi.nlm.nih.gov/9373591/
Pharmacodynamic trial of nimotuzumab in
unresectable squamous cell carcinoma of https://pubmed.ncbi.nlm.nih.gov/20371675
59
the head and neck: a SENDO Foundation /
study.
A Phase I Study of CUDC-101, a
Multitarget Inhibitor of HDACs, EGFR, and
https://pubmed.ncbi.nlm.nih.gov/25573383
60 HER2, in Combination with Chemoradiation
/
in Patients with Head and Neck Squamous
Cell Carcinoma.
61 Resistance of Nonmelanoma Skin Cancer https://pubmed.ncbi.nlm.nih.gov/27436804
to Nonsurgical Treatments. Part II: /
Photodynamic Therapy, Vismodegib,
Cetuximab, Intralesional Methotrexate, and
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Radiotherapy.
Treatment of advanced, recurrent, resistant
to previous treatments basal and
https://pubmed.ncbi.nlm.nih.gov/19643007
62 squamous cell skin carcinomas with a
/
synergistic formulation of interferons. Open,
prospective study.
What is the role of adjuvant radiotherapy in
https://pubmed.ncbi.nlm.nih.gov/17279578 Article evaluate the effectiveness
63 the treatment of cutaneous squamous cell
/ of adjuvant radiotherapy
carcinoma with perineural invasion?

Induction chemotherapy with cisplatin and

ifosfamide in locally advanced inoperable https://pubmed.ncbi.nlm.nih.gov/28244461
64
squamous cell carcinoma of the head and /
neck: A single-institution experience.
Recent advances in field cancerization and
https://pubmed.ncbi.nlm.nih.gov/29904586
65 management of multiple cutaneous
/
squamous cell carcinomas.
Reproducibility and expression of skin
https://pubmed.ncbi.nlm.nih.gov/17021352
66 biomarkers in sun-damaged skin and
/
actinic keratoses.
Occurrence of other cancers among
67 patients with prior basal cell and squamous https://pubmed.ncbi.nlm.nih.gov/9488591/
cell skin cancer.
Hypopharyngeal Skin Cancer Following
Total Laryngectomy and Pectoralis Flap https://pubmed.ncbi.nlm.nih.gov/30888639
68
Reconstruction: Case Report and Literature /
Review.
Combined Treatments with Photodynamic https://pubmed.ncbi.nlm.nih.gov/26516853
69
Therapy for Non-Melanoma Skin Cancer. /
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https://pubmed.ncbi.nlm.nih.gov/19822074
70 Systemic sclerosis and cancer.
/
Compassionate use of vismodegib and
adjuvant radiotherapy in the treatment of
https://pubmed.ncbi.nlm.nih.gov/24629372
71 multiple locally advanced and inoperable
/
basal cell carcinomas and squamous cell
carcinomas of the skin.
EORTC trial 11001: distribution of two 10B-
compounds in patients with squamous cell https://pubmed.ncbi.nlm.nih.gov/19602035
72
carcinoma of head and neck, a translational /
research/phase 1 trial.

The effect of Mepitel Film on acute

radiation-induced skin reactions in head https://pubmed.ncbi.nlm.nih.gov/29072852
73
and neck cancer patients: a feasibility /
study.
Gemcitabine concurrent with radiation
https://pubmed.ncbi.nlm.nih.gov/19357741
74 therapy for locally advanced head and neck
/
carcinomas.
[EPIDERMOID CARCINOMA IN THE
NEOVAGINA OF A PATIENT WITH
https://pubmed.ncbi.nlm.nih.gov/32142241
75 MAYER-ROKITANSKY-KUSTER-HAUSER
/
SYNDROME. CASE REPORT AND
LITERATURE REVIEW].
76 Differentiation of irradiation and cetuximab https://pubmed.ncbi.nlm.nih.gov/23855804
induced skin reactions in patients with /
locally advanced head and neck cancer
undergoing radioimmunotherapy: the
HICARE protocol (head and neck cancer:
immunochemo and radiotherapy with
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general criteria)
erbitux) - a multicenter phase IV trial.
Treatment of actinic keratosis through
inhibition of cyclooxygenase-2: Potential https://pubmed.ncbi.nlm.nih.gov/30523664
77
mechanism of action of diclofenac sodium /
3% in hyaluronic acid 2.5.
ACR Appropriateness Criteria() Aggressive
https://pubmed.ncbi.nlm.nih.gov/26791005
78 Nonmelanomatous Skin Cancer of the
/
Head and Neck.
Systematic Review of Modern Case Series
https://pubmed.ncbi.nlm.nih.gov/32530749
79 of Squamous Cell Cancer Arising in a
/
Chronic Ulcer (Marjolin's Ulcer) of the Skin.
PTEN: new insights into its regulation and https://pubmed.ncbi.nlm.nih.gov/19340009
80
function in skin cancer. /

Study highlighting the limitations

Localized Non-melanoma Skin Cancer:
81 Risk Factors of Post-surgical Relapse and
Role of Postoperative Radiotherapy.
Cutaneous Squamous Cell Carcinomas in
82
Organ Transplant Recipients.
Metatypical basal cell carcinoma: a clinical
83
review.
84 A phase II trial of 10-ethyl-10-deaza-
aminopterin, a novel antifolate, in patients
with advanced and/or recurrent squamous
cell carcinoma of the head and neck. The
of current understanding of the
independent prognosis of each
https://pubmed.ncbi.nlm.nih.gov/33034759 risk factor are needed to better
/ define the role of adjuvant RT on
outcome of localized NMSC and
standardize its indications in the
clinical setting.
https://pubmed.ncbi.nlm.nih.gov/26239556
/
https://pubmed.ncbi.nlm.nih.gov/18992138
/
https://pubmed.ncbi.nlm.nih.gov/1586620/
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EORTC Head and Neck Cancer
Cooperative Group.
Merkel Cell Carcinoma of the Hand: A https://pubmed.ncbi.nlm.nih.gov/28149222
85
Case Report and Review of the Literature. /
Radionuclide therapy of skin cancers and
86 Bowen's disease using a specially https://pubmed.ncbi.nlm.nih.gov/9170430/
designed skin patch.
Enhanced radiation sensitivity and radiation
recall dermatitis (RRD) after hypericin https://pubmed.ncbi.nlm.nih.gov/16948841
87
therapy -- case report and review of /
literature.
Contemporary management of head and https://pubmed.ncbi.nlm.nih.gov/19637508
88
neck cancers. /
Marjolin's ulcers in the post-burned lesions https://pubmed.ncbi.nlm.nih.gov/25325060
89
and scars. /

Advances in the Treatment of Advanced

https://pubmed.ncbi.nlm.nih.gov/28561682
90 Extracutaneous Melanomas and
/
Nonmelanoma Skin Cancers.
https://pubmed.ncbi.nlm.nih.gov/21729024
91 Roles of the immune system in skin cancer.
/
Correlation Between the Severity of
Cetuximab-Induced Skin Rash and Clinical https://pubmed.ncbi.nlm.nih.gov/27212198
92
Outcome for Head and Neck Cancer /
Patients: The RTOG Experience.
Novel treatment options for nonmelanoma
https://pubmed.ncbi.nlm.nih.gov/26648763
93 skin cancer: focus on electronic
/
brachytherapy.
Phase II study of single-agent https://pubmed.ncbi.nlm.nih.gov/25091317
94
panitumumab in patients with incurable /
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cutaneous squamous cell carcinoma.
Non-melanoma skin cancer treated with
https://pubmed.ncbi.nlm.nih.gov/28115960
95 high-dose-rate brachytherapy: a review of
/
literature.
Successful management of cutaneous
lymphangitis carcinomatosa arising from
https://pubmed.ncbi.nlm.nih.gov/31699140
96 cervical cancer with paclitaxel-cisplatin and
/
bevacizumab combination therapy: a case
report and review of the literature.
[Immunosuppressive drugs and the
https://pubmed.ncbi.nlm.nih.gov/23038197
97 development of skin cancer after organ
/
transplantation].
Gemcitabine-Based Chemoradiation in the
Treatment of Locally Advanced Head and https://pubmed.ncbi.nlm.nih.gov/26712958
98
Neck Cancer: Systematic Review of /
Literature and Meta-Analysis.

Intensity modulated radiotherapy (IMRT)

with concurrent chemotherapy as definitive https://pubmed.ncbi.nlm.nih.gov/25175056
99
treatment of locally advanced esophageal /
cancer.
Twice-weekly palliative radiotherapy for
https://pubmed.ncbi.nlm.nih.gov/27146764
100 locally very advanced head and neck
/
cancers.
Cutaneous Squamous Cell Carcinoma: The article describes different
https://pubmed.ncbi.nlm.nih.gov/33572373
101 From Pathophysiology to Novel approaches in in cSSC
/
Therapeutic Approaches. treatment.
Tumor Control Probability Modeling for
https://pubmed.ncbi.nlm.nih.gov/34079752
102 Radiation Therapy of Keratinocyte
/
Carcinoma.
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Clinical experience of SIB-IMRT in anal https://pubmed.ncbi.nlm.nih.gov/25199879
103
cancer and selective literature review. /
Combined modality treatment for locally
advanced squamous-cell carcinoma of the
https://pubmed.ncbi.nlm.nih.gov/11521786
104 oropharynx in a woman with Bloom's
/
syndrome: a case report and review of the
literature.
Gefitinib for patients with incurable
https://pubmed.ncbi.nlm.nih.gov/28964539
105 cutaneous squamous cell carcinoma: A
/
single-arm phase II clinical trial.
Severe radiation therapy-related soft tissue
https://pubmed.ncbi.nlm.nih.gov/19536857
106 toxicity in a patient with porphyria cutanea
/
tarda: a literature review.
Designation Products: Boron Neutron
https://pubmed.ncbi.nlm.nih.gov/33928712
107 Capture Therapy for Head and Neck
/
Carcinoma.
108 Skin cancers in organ transplant recipients. https://pubmed.ncbi.nlm.nih.gov/9869876/
Swiss clinical practice guidelines on field https://pubmed.ncbi.nlm.nih.gov/25539459
109
cancerization of the skin. /
https://pubmed.ncbi.nlm.nih.gov/22031630
110 Extramammary Paget disease.
/
Photodynamic therapy of superficial nasal
https://pubmed.ncbi.nlm.nih.gov/18798792
111 planum squamous cell carcinomas in cats:
/
55 cases.
Supraestructure maxillectomy and orbital
exenteration for treatment of basal cell https://pubmed.ncbi.nlm.nih.gov/17998643
112
carcinoma of inferior eyelid: case report /
and review.
Cutaneous Squamous Cell Carcinoma in https://pubmed.ncbi.nlm.nih.gov/33800195
113
the Age of Immunotherapy. /
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general criteria)
An ALK-positive lung adenocarcinoma with
https://pubmed.ncbi.nlm.nih.gov/32819126
114 gastric and skin metastasis: a case report
/
and literature review.
[Diagnosis and therapy for penile cancer: a https://pubmed.ncbi.nlm.nih.gov/18799036
115
report of 46 cases with literature review]. /
Molecular mechanisms of inhibition of
photocarcinogenesis by silymarin, a https://pubmed.ncbi.nlm.nih.gov/20372777
116
phytochemical from milk thistle (Silybum /
marianum L. Gaertn.) (Review).
Bilateral hand squamous-cells carcinoma in
patient affected with non-Hodgkin https://pubmed.ncbi.nlm.nih.gov/26712073
117
lymphoma. Case report and literature /
review.
[Basal cell carcinoma of the vulva: 21 https://pubmed.ncbi.nlm.nih.gov/11226893
118
cases]. /
Closure of laryngectomy defects in the age https://pubmed.ncbi.nlm.nih.gov/21416549
119
of chemoradiation therapy. /
The application of Levulan-based
photodynamic therapy with imiquimod in https://pubmed.ncbi.nlm.nih.gov/22293891
120
the treatment of recurrent basal cell /
carcinoma.
[Oncological principles of surgery in the https://pubmed.ncbi.nlm.nih.gov/15902334
121
periorbital region]. /
A Dose Escalation Clinical Trial of Single-
Fraction Carbon Ion Radiotherapy for https://pubmed.ncbi.nlm.nih.gov/28007628
122
Peripheral Stage I Non-Small Cell Lung /
Cancer.
Squamous carcinoma in a major salivary
https://pubmed.ncbi.nlm.nih.gov/11371224
123 gland: a review of the diagnostic
/
considerations.
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[Squamous cell carcinomas of the scrotum: https://pubmed.ncbi.nlm.nih.gov/26113906
124
about 7 cases with review of the literature]. /
A brief report on the safety study of
induction chemotherapy followed by
https://pubmed.ncbi.nlm.nih.gov/18520806
125 synchronous radiotherapy and cetuximab in
/
stage III non-small cell lung cancer
(NSCLC): SCRATCH study.
Locally Advanced (T3-T4 or N+) Anal
Cancer Treated with Simultaneous https://pubmed.ncbi.nlm.nih.gov/27069197
126
Integrated Boost Radiotherapy and /
Concurrent Chemotherapy.
Radical chemo-irradiation using intensity-
modulated radiotherapy for locally
https://pubmed.ncbi.nlm.nih.gov/28485335
127 advanced head and neck cancer in elderly
/
patients: Experience from a tertiary care
center in South India.
Genitogluteal porokeratosis in an HIV-
https://pubmed.ncbi.nlm.nih.gov/29634882
128 positive man: a case report and review of
/
the literature on genital porokeratosis.
Randomized trial of hyperfractionation
versus conventional fractionation in T2 https://pubmed.ncbi.nlm.nih.gov/25035199
129
squamous cell carcinoma of the vocal cord /
(RTOG 9512).
Guidelines for delineation of lymphatic
https://pubmed.ncbi.nlm.nih.gov/21854585
130 clinical target volumes for high conformal
/
radiotherapy: head and neck region.
Psoriasis, PUVA, and skin cancer--
https://pubmed.ncbi.nlm.nih.gov/10537001
131 molecular epidemiology: the curious
/
question of T-->A transversions.
[Targeting of epidermal growth factor https://pubmed.ncbi.nlm.nih.gov/14763143
132
receptor and applications in ORL cancer]. /
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In vivo confocal microscopy in dermatology: https://pubmed.ncbi.nlm.nih.gov/23338938
133
from research to clinical application. /
Solid tumor second primary neoplasms: https://pubmed.ncbi.nlm.nih.gov/24331190
134
who is at risk, what can we do? /
Enhancing the effectiveness of drug-based
https://pubmed.ncbi.nlm.nih.gov/12614180
135 cancer therapy by electroporation
/
(electropermeabilization).
Intensity-modulated radiation therapy with
simultaneous integrated boost combined
https://pubmed.ncbi.nlm.nih.gov/25950188
136 with concurrent chemotherapy for the
/
treatment of anal cancer patients: 4-year
results of a consecutive case series.
Avelumab and cetuximab as a therapeutic
combination: An overview of scientific https://pubmed.ncbi.nlm.nih.gov/33989949
137
rationale and current clinical trials in /
cancer.
Radiation recall phenomenon presenting as
https://pubmed.ncbi.nlm.nih.gov/25579560
138 myositis triggered by carboplatin plus
/
paclitaxel and related literature review.
[Merkel cell carcinoma: a presentation of 5 https://pubmed.ncbi.nlm.nih.gov/21345393
139
cases and a review of the literature]. /
The use of pharmacokinetic and
pharmacodynamic end points to determine
https://pubmed.ncbi.nlm.nih.gov/17442658
140 the dose of AQ4N, a novel hypoxic cell
/
cytotoxin, given with fractionated
radiotherapy in a phase I study.

Cisplatin-based chemoradiation plus

https://pubmed.ncbi.nlm.nih.gov/20810547
141 cetuximab in locally advanced head and
/
neck cancer: a phase II clinical study.
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Acceleration of hyperfractionated
https://pubmed.ncbi.nlm.nih.gov/17111432
142 chemoradiation regimen for advanced head
/
and neck cancer.
Effective treatment of anal cancer in the https://pubmed.ncbi.nlm.nih.gov/15798772
143
elderly with low-dose chemoradiotherapy. /
Problem of sequence and fractionation in
144 the clinical application of combined heat https://pubmed.ncbi.nlm.nih.gov/6380717/
and radiation.
Phase I clinical study of multiple epitope
peptide vaccine combined with https://pubmed.ncbi.nlm.nih.gov/24708624
145
chemoradiation therapy in esophageal /
cancer patients.
Human papillomavirus and the
https://pubmed.ncbi.nlm.nih.gov/10474513
146 development of non-melanoma skin
/
cancer.
Superficial photodynamic therapy with
147 topical 5-aminolaevulinic acid for superficial https://pubmed.ncbi.nlm.nih.gov/8123497/
primary and secondary skin cancer.
Fractionated laser resurfacing corrects the
https://pubmed.ncbi.nlm.nih.gov/22377757
148 inappropriate UVB response in geriatric
/
skin.
Parotid gland metastasis of
https://pubmed.ncbi.nlm.nih.gov/20146900
149 nasopharyngeal carcinoma: case report
/
and review of the literature.
Randomized phase 2 study of concomitant
chemoradiotherapy using weekly
https://pubmed.ncbi.nlm.nih.gov/19634161
150 carboplatin/paclitaxel with or without daily
/
subcutaneous amifostine in patients with
locally advanced head and neck cancer.
Eruptive purpuric papules on the arms; a https://pubmed.ncbi.nlm.nih.gov/24456949
151
case of chemotherapy-induced /
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inflammation of actinic keratoses and
review of the literature.
Bleomycin in advanced squamous cell
carcinoma: a random controlled trial.
152 https://pubmed.ncbi.nlm.nih.gov/55288/
Report of Medical Research Council
Working Party on Bleomycin.
Perineural spread of cutaneous malignancy
to the brain: a review of the literature and https://pubmed.ncbi.nlm.nih.gov/15816051
153
five patients treated with stereotactic /
radiotherapy.
Double-blind, randomized phase 3 trial of
low-dose 13-cis retinoic acid in the
prevention of second primaries in head and
https://pubmed.ncbi.nlm.nih.gov/28786105
154 neck cancer: Long-term follow-up of a trial
/
of the Eastern Cooperative Oncology
Group-ACRIN Cancer Research Group
(C0590).
Safety and radiosensitizing efficacy of
sanazole (AK 2123) in oropharyngeal https://pubmed.ncbi.nlm.nih.gov/17192685
155
cancers: randomized controlled double /
blind clinical trial.

 Studies in a search result: 155

 Picked studies: 155
 Studies selected for analysis: 9
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Search Results
Data Base: PubMed
Link to search results: ((Radiotherapy) OR (Radiation therapy)) AND (Keloid) - Search Results - PubMed (nih.gov)
Number of found studies: 38
Search formula:
((Radiotherapy) OR (Radiation therapy)) AND (Keloid)
Additional filters:
Free Full Text; Clinical Trial; Meta-Analysis; Randomized Controlled Trial; Review; Systematic Review; Date range 2000-
2021 yr.

№ Title
Radiation Therapy in Keloids
1 Treatment: History, Strategy,
Effectiveness, and Complication.
Keloid and Hypertrophic Scars Are
2 the Result of Chronic Inflammation
in the Reticular Dermis.
Overview of surgical scar
3
prevention and management.
Assessing keloid recurrence
4 following surgical excision and
radiation.
Keloids: Current and emerging
5 therapy, radiotherapy, cryotherapy, laser
therapies.
6 Keloids: A Review of Etiology,
Prevention, and Treatment.
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criteria)
Radiation therapy combined with surgical
excision was considered as one of the most
effective treatment plans for keloid lesions.
However, there was no unanimity found
https://pubmed.ncbi.nlm.nih.gov/28685723
over present literatures regarding the issue
/
on optimized treatment strategy for keloids.
We here provide a comprehensive review
over this issue and emphasize on the
influencing factors.
https://pubmed.ncbi.nlm.nih.gov/28287424
/
https://pubmed.ncbi.nlm.nih.gov/24932073
/
https://pubmed.ncbi.nlm.nih.gov/33225004
/
In this paper, we explore the literature and
summarise the general concepts
surrounding keloid development and review
both current (corticosteroids, surgical
excision, silicone-based products, pressure
https://pubmed.ncbi.nlm.nih.gov/32844039
/
therapy, imiquimod and 5-fluorouracil) and
emerging (stem cell therapy, mitomycin C,
verapamil, interferons, bleomycin,
botulinum toxin type A and angiotensin-
converting enzyme inhibitors) treatments.
https://pubmed.ncbi.nlm.nih.gov/32308783 The purpose of this report is to examine the
/ current literature and review the
mechanisms of action, efficacy, and side

X-RAY THERAPY SYSTEM
№ Title
7 Keloid.
Management of keloids and
8
hypertrophic scars.
Diagnosis and Treatment of
Keloids and Hypertrophic Scars- https://pubmed.ncbi.nlm.nih.gov/31890718
9 facilities, (3) the rationale behind each
Japan Scar Workshop Consensus
Document 2018.
Keloids and Hypertrophic Scars
Can Now Be Cured Completely:
Recent Progress in Our
Understanding of the
10
Pathogenesis of Keloids and
Hypertrophic Scars and the Most
Promising Current Therapeutic
Strategy.
11 A Review of Current Keloid
Management: Mainstay
Monotherapies and Emerging
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criteria)
effects of different keloid therapies.
https://pubmed.ncbi.nlm.nih.gov/29939676
/
https://pubmed.ncbi.nlm.nih.gov/19621835
/
he Consensus Document is provided in this
article. It describes (1) the diagnostic
algorithm for pathological scars and how to
differentiate them from clinically similar
benign and malignant tumors, (2) the
general treatment algorithms for keloids
and hypertrophic scars at different medical
/
treatment for keloids and hypertrophic
scars, and (4) the body site-specific
treatment protocols for these scars. We
believe that this Consensus Document will
be helpful for physicians from all over the
world who treat keloids and hypertrophic
scars.
https://pubmed.ncbi.nlm.nih.gov/27180789
/
https://pubmed.ncbi.nlm.nih.gov/32705533 This review details current treatment of
/ keloids with injections (bleomycin,
verapamil, hyaluronic acid and

X-RAY THERAPY SYSTEM
№ Title
Approaches.
The Latest Strategy for Keloid and
Hypertrophic Scar Prevention and https://pubmed.ncbi.nlm.nih.gov/32741903
12
Treatment: The Nippon Medical
School (NMS) Protocol.
Radiation Therapy In The
13
Treatment Of Keloids.
RADIATION THERAPY for the
14 Adjunctive Treatment of Surgically
Excised Keloids: A Review.
15 A Retrospective Registry Study https://pubmed.ncbi.nlm.nih.gov/33584951
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hyaluronidase, botulinum toxin, and
collagenase), cryotherapy, laser,
radiofrequency ablation, radiation,
extracorporeal shockwave therapy,
pentoxifylline, and dupilumab.
In 2006, we established a scar/keloid-
specialized unit in the Department of
Plastic, Reconstructive, and Aesthetic
Surgery at Nippon Medical School (NMS) in
Tokyo, Japan. In the ensuing 15 years, we
treated approximately 2,000 new
scar/keloid patients annually. This
extensive experience has greatly improved
the efficacy of the treatments we offer.
Therefore, we discuss here the latest NMS
protocol for preventing and treating keloids
/
and hypertrophic scars. While this protocol
was optimized for Japanese patients, our
experience with a growing body of non-
Japanese patients suggests that it is also
effective in other ethnicities. The extensive
evidence-based experience underlying the
NMS protocol suggests that it may be
suitable as the foundation of a standard
international prevention/treatment algorithm
for pathological scars.
https://pubmed.ncbi.nlm.nih.gov/29763148
/
The objective of this review was to explore
https://pubmed.ncbi.nlm.nih.gov/28979658
the use of radiation therapy as an adjuvant
/
to surgically excised keloids.
Authors sought to assess keloid recurrence
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№ Title
criteria)
Evaluating the Long-Term Efficacy
rates when superficial radiation therapy
and Safety of Superficial Radiation
/ (SRT) was applied following surgical
Therapy Following Excision of
excision.
Keloid Scars.
Intralesional cryotherapy versus
excision and corticosteroids or
https://pubmed.ncbi.nlm.nih.gov/24354714
16 brachytherapy for keloid
/
treatment: study protocol for a
randomised controlled trial.
Brachytherapy in the adjuvant
https://pubmed.ncbi.nlm.nih.gov/29799578
17 management of keloid scars:
/
literature review.
This review discusses available patient-
Patient-reported outcomes for https://pubmed.ncbi.nlm.nih.gov/30375208 reported outcome measures for keloids, as
18
keloids: a systematic review. / well as patient-reported outcomes across
current treatment modalities.
[Advancement in phodynamic
https://pubmed.ncbi.nlm.nih.gov/30643057
19 therapy for non-neoplastic skin
/
diseases].
Keloid scarring: new treatments https://pubmed.ncbi.nlm.nih.gov/20096165
20
ahead. /
Basics of Radiation Biology When
https://pubmed.ncbi.nlm.nih.gov/28515727
21 Treating Hyperproliferative Benign
/
Diseases.
Adjuvant single-fraction
https://pubmed.ncbi.nlm.nih.gov/24801475
22 radiotherapy is safe and effective
/
for intractable keloids.
https://pubmed.ncbi.nlm.nih.gov/21034705
23 [Pseudofolliculitis barbae].
/
Ear keloids: a review and update https://pubmed.ncbi.nlm.nih.gov/26527968
24
of treatment options. /
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№ Title
Keloids: pathophysiology and
25
management.
 Studies in a search result: 38
 Picked studies: 25
 Studies selected for analysis: 10
criteria)
In this review, authors highlight the clinical
https://pubmed.ncbi.nlm.nih.gov/18328203
features, pathophysiology and management
/
of keloids.
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Search Results
Data Base: Cochrane Library
Link to search results: N/A
Number of found studies: 4 (3 Reviews and 1 Protocol)

Search formula:
((Radiotherapy) OR (Radiation therapy)) AND (("Basal Cell Carcinoma") OR (("Squamous Cell Carcinoma") AND (Skin)) OR
(Keloid))
Additional filters:
Custom date range.
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Link
№ Title

Radiotherapy and
corticosteroids for
1 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010883.pub2/full
preventing and treating
keloid scars
Exfoliative cytology for
diagnosing basal cell
2 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013187/full
carcinoma and other skin
cancers in adults
Interventions for basal cell
3 https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003412.pub3/full
carcinoma of the skin
Interventions for non‐
4 metastatic squamous cell https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD007869.pub2/full
carcinoma of the skin

 Studies in a search result: 4

 Picked studies: 4
 Studies selected for analysis: 0
Comment: a few appropriate articles were found, but no one in free access.
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Search Results
Data Base: American Society of Radiation Oncology (ASTRO) guidelines.
Link to search results: https://www.astro.org/Patient-Care-and-Research/Clinical-Practice-Statements/Clinical-Practice-
Guidelines
Number of found studies: 1

Search formula:
No any specific search or filters were used. ASTRO Guidelines web page contain a few tabs, which correspond to target
localization. All tabs were reviewed, and results are represented in table below.
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№ Title
general criteria)
https://www.astro.org/Patient-Care-and-
Radiation Therapy for Glioblastoma Research/Clinical-Practice-
1 -
(ASTRO) – 2016 Statements/ASTRO-39;s-guideline-on-
radiation-therapy-for-glio
https://www.astro.org/Patient-Care-and-
Radiotherapeutic and Surgical
Research/Clinical-Practice-
2 Management for Newly Diagnosed Brain -
Statements/ASTRO-39;s-guideline-on-
Metastasis(es) (ASTRO) – 2012
brain-metasteses
Management of Hereditary Breast Cancer https://www.astro.org/Patient-Care-and-
3 -
(ASCO/ASTRO/SSO) – 2020 Research/Clinical-Practice-Statements
Margins for Breast-Conserving Surgery https://www.astro.org/Patient-Care-and-
With Whole-Breast Irradiation in Ductal Research/Clinical-Practice-
5 -
Carcinoma in Situ (SSO/ASTRO/ASCO) – Statements/ASTRO-guideline-on-BCS-
2016/Affirmed 2019 with-WBI-in-DCIS
https://www.astro.org/Patient-Care-and-
Radiation Therapy for the Whole-Breast Research/Clinical-Practice-
6 -
(ASTRO) – 2018 Statements/ASTRO-39;s-+guideline-
on-whole-breast-irradiation
https://www.astro.org/Patient-Care-and-
Accelerated Partial Breast Irradiation Research/Clinical-Practice-
7 -
(ASTRO) – 2009/Updated 2016 Statements/ASTRO-39;s-guideline-on-
accelerated-partial-breast
https://www.astro.org/Patient-Care-and-
Postmastectomy Radiotherapy
Research/Clinical-Practice-
8 (ASCO/ASTRO/SSO) – 2001/Updated -
Statements/ASTRO-39;s-guideline-on-
2016
post-mastectomy-radiothera
Margins for Breast-Conserving Surgery https://www.astro.org/Patient-Care-and-
With Whole-Breast Irradiation in Stages I Research/Clinical-Practice-
9 -
and II Invasive Breast Cancer Statements/ASTRO-39;s-guideline-on-
(SSO/ASTRO) – 2014 BCS-with-WBI-in-stages-I-a
 Product
X-RAY THERAPY SYSTEM
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№ Title
Treatment of Non-Metastatic Muscle-
Invasive Bladder Cancer
10
(AUA/ASCO/ASTRO/SUO) – Amended
2020, Original 2017
Adjuvant and Salvage Radiation Therapy
11
After Prostatectomy (ASTRO/AUA) – 2018 Statements/ASTRO-39;s-guideline-on-
Hypofractionation for Localized Prostate
12
Cancer (ASTRO/ASCO/AUA) – 2018
Clinically Localized Prostate Cancer
13
(AUA/ASTRO/SUO) – 2017
Radiation Therapy for Rectal Cancer
14
(ASTRO) – 2020
Radiation Therapy for Pancreatic Cancer
15
(ASTRO) – 2019
Radiation Therapy for Cervical Cancer
16
(ASTRO) – 2020
Postoperative Radiation Therapy for
17
Endometrial Cancer (ASTRO) – 2014
Document Ref.
TECHNICAL
CLINICAL
DOCUMENTATION
EVALUATION
Link Short description (if article met
general criteria)
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
bladder-cancer
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
adjuvant-and-salvage-RT-af
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
hypofractionation-for-loca
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-evidence-
based-guideline-on-clinically
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/Clinical-Practice-
Guidelines/Rectal-GL
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-Guideline-on-
Pancreatic-Cancer
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice- -
Statements/Cervical-Cancer-Guideline
https://www.astro.org/Patient-Care-and-
-
Research/Clinical-Practice-
 Product
X-RAY THERAPY SYSTEM
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№ Title
Radiation Therapy for Oropharyngeal
18 Squamous Cell Carcinoma (ASTRO) –
2017
Treatment of Metastatic Carcinoma and
19 Myeloma of the Femur
(MSTS/ASTRO/ASCO) – 2020
Palliative Thoracic Radiation Therapy in
20
Lung Cancer (ASTRO) – 2018
Palliative Radiation Therapy for Bone
21
Metastases (ASTRO) – 2017
Radiation Therapy and Surgery for Newly
22 Diagnosed Brain Metastasis/es (ASTRO) –
2012
23 ASTRO Guideline on Definitive and
Postoperative Radiation Therapy for Basal
and Squamous Cell Cancers of the Skin
Document Ref.
TECHNICAL
CLINICAL
DOCUMENTATION
EVALUATION
Link Short description (if article met
general criteria)
Statements/ASTRO-39;s-guideline-on-
postop-RT-in-endometrial-c
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
oropharyngeal-squamous-cel
http://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
Statements/Clinical-Practice- -
Guidelines/Metastatic-Carcinoma-and-
Myeloma-of-the-Femur
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
Palliative-Radiation-Thera
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
Palliative-Radiation-T-(1)
https://www.astro.org/Patient-Care-and-
Research/Clinical-Practice-
-
Statements/ASTRO-39;s-guideline-on-
brain-metasteses
https://www.astro.org/Patient-Care-and- The role of RT for BCC and cSCC has been
Research/Clinical-Practice- poorly defined owing to lack of high-quality
evidence. To the
Statements/Skin-Cancer-Guideline best of our knowledge, no evidence-based
clinical practice guidelines, endorsed by a
large professional
organization currently exist to provide
direction on the use of RT for these
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Link Short description (if article met

№ Title
general criteria)
malignancies. In view of the lack of
consensus on this subject, ASTRO
commissioned a task force to formulate
evidence-based recommendations
for the use of definitive and postoperative RT
in patients with BCC and cSCC.
https://www.astro.org/Patient-Care-and-
Radiation Therapy for Small Cell Lung Research/Clinical-Practice-
24 -
Cancer (ASTRO) - 2020 Statements/Small-Cell-Lung-Cancer-
Guideline
https://www.astro.org/Patient-Care-and-
Palliative Thoracic Radiation Therapy for
Research/Clinical-Practice-
25 Non-Small Cell Lung Cancer (ASTRO) - -
Statements/ASTRO-39;s-guideline-on-
2011/2018 Update
Palliative-Radiation-Thera
https://www.astro.org/Patient-Care-and-
Stereotactic Body Radiation Therapy
Research/Clinical-Practice-
26 (SBRT) for Early-Stage Non-Small Cell -
Statements/ASTRO-39;s-guideline-on-
Lung Cancer (ASTRO) - 2017
SBRT-for-early-stage-NSCLC
https://www.astro.org/Patient-Care-and-
Definitive and Adjuvant Radiation Therapy
Research/Clinical-Practice-
27 in Locally Advanced Non-Small Cell Lung -
Statements/ASTRO-39;s-guideline-on-
Cancer (ASTRO) - 2015
definitive-and-adjuvant-RT

 Studies in a search result: 27

 Picked studies: 27
 Studies selected for analysis: 1
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Search Results
Data Base: The National Comprehensive Cancer Network (NNCN) guidelines.
Link to search results: https://www.nccn.org/guidelines/category_1
Number of found studies:

Search formula:
No any specific search or filters were used. NCCN Guidelines web page contain a few tabs, which correspond to target
localization. All tabs were reviewed, and results are represented in table below.
 Product Document Ref.
TECHNICAL
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Link Short description (if article met

№ Title
1 Acute Lymphoblastic Leukemia
2 Acute Myeloid Leukemia
3 Anal Carcinoma
4 Basal Cell Skin Cancer
5 B-Cell Lymphomas
6 Bladder Cancer
7 Bone Cancer
8 Breast Cancer
9 Central Nervous System Cancers
10 Cervical Cancer
general criteria)
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1410
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1411
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1414
NCCN consensus treatment
https://www.nccn.org/guidelines/nccn-
guideline describing different
guidelines/guidelines-detail?
treatment modalities of BCC,
category=1&id=1416
including radiotherapy.
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1480
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1417
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1418
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1419
https://www.nccn.org/guidelines/nccn-
guidelines/guidelines-detail? -
category=1&id=1425
https://www.nccn.org/guidelines/nccn- -
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Link Short description (if article met

№ Title
general criteria)
guidelines/guidelines-detail?
category=1&id=1426
Chronic Lymphocytic https://www.nccn.org/guidelines/nccn-
11 Leukemia/Small Lymphocytic guidelines/guidelines-detail? -
Lymphoma category=1&id=1478
https://www.nccn.org/guidelines/nccn-
12 Chronic Myeloid Leukemia guidelines/guidelines-detail? -
category=1&id=1427
https://www.nccn.org/guidelines/nccn-
13 Colon Cancer guidelines/guidelines-detail? -
category=1&id=1428
https://www.nccn.org/guidelines/nccn-
14 Dermatofibrosarcoma Protuberans guidelines/guidelines-detail? -
category=1&id=1430
https://www.nccn.org/guidelines/nccn-
Esophageal and Esophagogastric
15 guidelines/guidelines-detail? -
Junction Cancers
category=1&id=1433
https://www.nccn.org/guidelines/nccn-
16 Gastric Cancer guidelines/guidelines-detail? -
category=1&id=1434
https://www.nccn.org/guidelines/nccn-
Gastrointestinal Stromal Tumors
17 guidelines/guidelines-detail? -
(GIST)
category=1&id=1507
https://www.nccn.org/guidelines/nccn-
18 Gestational Trophoblastic Neoplasia guidelines/guidelines-detail? -
category=1&id=1489
https://www.nccn.org/guidelines/nccn-
19 Hairy Cell Leukemia guidelines/guidelines-detail? -
category=1&id=1481
https://www.nccn.org/guidelines/nccn-
20 Head and Neck Cancers -
guidelines/guidelines-detail?
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Link Short description (if article met

№ Title
general criteria)
category=1&id=1437
https://www.nccn.org/guidelines/nccn-
21 Hepatobiliary Cancers guidelines/guidelines-detail? -
category=1&id=1438
https://www.nccn.org/guidelines/nccn-
22 Histiocytic Neoplasms guidelines/guidelines-detail? -
category=1&id=1502
https://www.nccn.org/guidelines/nccn-
23 Hodgkin Lymphoma guidelines/guidelines-detail? -
category=1&id=1439
https://www.nccn.org/guidelines/nccn-
24 Kaposi Sarcoma guidelines/guidelines-detail? -
category=1&id=1485
https://www.nccn.org/guidelines/nccn-
25 Kidney Cancer guidelines/guidelines-detail? -
category=1&id=1440
https://www.nccn.org/guidelines/nccn-
26 Malignant Pleural Mesothelioma guidelines/guidelines-detail? -
category=1&id=1442
https://www.nccn.org/guidelines/nccn-
27 Melanoma: Cutaneous guidelines/guidelines-detail? -
category=1&id=1492
https://www.nccn.org/guidelines/nccn-
28 Melanoma: Uveal guidelines/guidelines-detail? -
category=1&id=1488
https://www.nccn.org/guidelines/nccn-
29 Merkel Cell Carcinoma guidelines/guidelines-detail? -
category=1&id=1444
https://www.nccn.org/guidelines/nccn-
30 Multiple Myeloma guidelines/guidelines-detail? -
category=1&id=1445
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TECHNICAL
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№ Title
general criteria)
https://www.nccn.org/guidelines/nccn-
31 Myelodysplastic Syndromes guidelines/guidelines-detail? -
category=1&id=1446
Myeloid/Lymphoid Neoplasms with https://www.nccn.org/guidelines/nccn-
32 Eosinophilia and Tyrosine Kinase guidelines/guidelines-detail? -
Fusion Genes category=1&id=1505
https://www.nccn.org/guidelines/nccn-
33 Myeloproliferative Neoplasms guidelines/guidelines-detail? -
category=1&id=1477
https://www.nccn.org/guidelines/nccn-
Neuroendocrine and Adrenal
34 guidelines/guidelines-detail? -
Tumors
category=1&id=1448
https://www.nccn.org/guidelines/nccn-
35 Non-Small Cell Lung Cancer guidelines/guidelines-detail? -
category=1&id=1450
https://www.nccn.org/guidelines/nccn-
36 Occult Primary guidelines/guidelines-detail? -
category=1&id=1451
https://www.nccn.org/guidelines/nccn-
Ovarian Cancer/Fallopian Tube
37 guidelines/guidelines-detail? -
Cancer/Primary Peritoneal Cancer
category=1&id=1453
https://www.nccn.org/guidelines/nccn-
38 Pancreatic Adenocarcinoma guidelines/guidelines-detail? -
category=1&id=1455
https://www.nccn.org/guidelines/nccn-
Pediatric Acute Lymphoblastic
39 guidelines/guidelines-detail? -
Leukemia
category=1&id=1496
https://www.nccn.org/guidelines/nccn-
Pediatric Aggressive Mature B-Cell
40 guidelines/guidelines-detail? -
Lymphomas
category=1&id=1504
41 Pediatric Hodgkin Lymphoma https://www.nccn.org/guidelines/nccn- -
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Link Short description (if article met

№ Title
general criteria)
guidelines/guidelines-detail?
category=1&id=1498
https://www.nccn.org/guidelines/nccn-
42 Penile Cancer guidelines/guidelines-detail? -
category=1&id=1456
https://www.nccn.org/guidelines/nccn-
43 Primary Cutaneous Lymphomas guidelines/guidelines-detail? -
category=1&id=1491
https://www.nccn.org/guidelines/nccn-
44 Prostate Cancer guidelines/guidelines-detail? -
category=1&id=1459
https://www.nccn.org/guidelines/nccn-
45 Rectal Cancer guidelines/guidelines-detail? -
category=1&id=1461
https://www.nccn.org/guidelines/nccn-
46 Small Bowel Adenocarcinoma guidelines/guidelines-detail? -
category=1&id=1495
https://www.nccn.org/guidelines/nccn-
47 Small Cell Lung Cancer guidelines/guidelines-detail? -
category=1&id=1462
https://www.nccn.org/guidelines/nccn-
48 Soft Tissue Sarcoma guidelines/guidelines-detail? -
category=1&id=1464
https://www.nccn.org/guidelines/nccn-
49 Squamous Cell Skin Cancer guidelines/guidelines-detail? -
category=1&id=1465
https://www.nccn.org/guidelines/nccn-
50 Systemic Light Chain Amyloidosis guidelines/guidelines-detail? -
category=1&id=1467
https://www.nccn.org/guidelines/nccn-
51 Systemic Mastocytosis -
guidelines/guidelines-detail?
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Link Short description (if article met

№ Title
general criteria)
category=1&id=1490
https://www.nccn.org/guidelines/nccn-
52 T-Cell Lymphomas guidelines/guidelines-detail? -
category=1&id=1483
https://www.nccn.org/guidelines/nccn-
53 Testicular Cancer guidelines/guidelines-detail? -
category=1&id=1468
https://www.nccn.org/guidelines/nccn-
54 Thymomas and Thymic Carcinomas guidelines/guidelines-detail? -
category=1&id=1469
https://www.nccn.org/guidelines/nccn-
55 Thyroid Carcinoma guidelines/guidelines-detail? -
category=1&id=1470
https://www.nccn.org/guidelines/nccn-
56 Uterine Neoplasms guidelines/guidelines-detail? -
category=1&id=1473
https://www.nccn.org/guidelines/nccn-
57 Vulvar Cancer guidelines/guidelines-detail? -
category=1&id=1476
https://www.nccn.org/guidelines/nccn-
Waldenström Macroglobulinemia /
58 guidelines/guidelines-detail? -
Lymphoplasmacytic Lymphoma
category=1&id=1475
https://www.nccn.org/guidelines/nccn-
59 Wilms Tumor (Nephroblastoma) guidelines/guidelines-detail? -
category=1&id=1500

 Studies in a search result: 59

 Picked studies: 59
 Studies selected for analysis: 0
 Product Document Ref.
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List of persons who coordinated this document

Medical Technical
Position
expert expert
Last Name A. A. Joseph V. Ganichev
Date 19.04.2019 19.04.2019
Signature
Position
Last Name
Date
Signature

List of persons who approved this document

Sign with blue inks
Department of Product Quality
Medical X-ray Manager Management
Position
Equipment Director
Director
Last Name V. Mishchenko V. Ganichev N. Shchurevich
Date 19.04.2019 19.04.2019 19.04.2019
Signature

Dissemination
Position, place of dissemination

Revisions Register
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