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Transcutol Aplicaciones Industria Del Cuidado Personal
Transcutol Aplicaciones Industria Del Cuidado Personal
Transcutol Aplicaciones Industria Del Cuidado Personal
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Applications
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Identity
Transcutol® CG
Properties
Efficacy booster
Powerful and versatile solubilizer
Odorless solvent for perfume
extraction
Co-surfactant for microemulsions
Multi-functional
Characteristics
High purity (> 99.5%)
INCI: Ethoxydiglycol Excellent tolerance profile
Identity
Transcutol® CG
INCI: Ethoxydiglycol
Description
Chemical name: Diethylene glycol
Dual nature
monoethyl ether
Small molecular weight hydrophilic and lipophilic
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Process
Goal: 100% purified grade
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Mode of action
Optimization of the efficacy of numerous actives
“Pull-effect”
“Push-effect” Strong affinity with the
Capacity to solubilize Powerful Diffusion lipids of the stratum
lipophilic actives in solubilizer enhancer corneum
polar solvents Vehicle the actives
inside the skin
(Mura P. et al., 2000;Yazdanian M. et al., 1995;Watkinson A.C., Hadgraft J., and Bye A., 1991;Rojas de Garcia J., 1991a)
Mode of action
in vitro substantiation – Interaction with hair internal proteins
Aim
Method
Results
Vs. other solvents, diethylene glycol monoether (Transcutol® CG) is the most effective in
inhibiting split-end generation of permed hair.
Transcutol® CG can interact with hair internal proteins.
Applications
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Clinical evaluation
Self tanning efficacy booster
Aim
Method
Results
Aim
Evaluation of the influence of Transcutol® CG on the intensity and duration of hair color
after application of dye creams
Method
Results
Transcutol® CG improves fixation of dye on the capillary fibers and enables to have a
longer-lasting and more uniform color
Applications
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Formulation & Regulation
Safety
Ocular irritation (single application of 0.1 ml of pure product): non-irritant (score = 9.00).
Acute oral toxicity (single oral administration of the pure product at a dose level of 5,000
mg/kg): non-toxic (LD50 > 5,000 mg/kg).
Primary cutaneous irritation on humans (single application of pure product under occlusive
patch for 48 hours): non-irritant.
Dermal toxicity by repeated applications for 28 days (daily application under patch for 6
hours/day for a 28-day period, at levels of 100, 300 and 1,000 mg/kg/day): non-toxic.
Formulation & Regulation
Formulation
o Process:
Slowly add the active to the
Transcutol® CG
Mix until the active is completely
dissolve
o Worldwide regulations
Worldwide approval (restricted use levels in Europe)
China: listed IECIC 2014-06
Australia TGA
Japan QD
Identity
Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol
Clinical
evaluation Mechanism
of action
Applications
Sunscreens
Sensoriality
Transcutol® CG helps to reduce the oiliness of the sunscreens
Applications
Toiletries
Antiperspirants
Transcutol® CG improves skin feel and decreases
tacky feel
Soaps
Transcutol® CG decreases the dissolution time of Triclocarban, antimicrobial active
o Anti-acne preparations
Solubilization of Benzoyl peroxide to avoid
grinding of this potentially explosive oxidizing
agent, and avoid grainy and scratching
sensation
Applications
Compatible with all types of formulations
Specific applications
Skin Care:
Anti-acne preparations
Sun Care:
Sunscreens
Self-tanning products
Hair care:
Conditioners
Hair dyes
Toiletries:
Antiperspirants
Antimicrobial soaps
Transcutol® CG
INCI: Ethoxydiglycol
Key features:
o Efficacy booster