TRANSCUTOL® CG

Superior solubilizer & Efficacy booster

 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
Identity
Transcutol® CG

Properties
Efficacy booster
Powerful and versatile solubilizer
Odorless solvent for perfume
extraction
Co-surfactant for microemulsions
Multi-functional

Characteristics
High purity (> 99.5%)
INCI: Ethoxydiglycol Excellent tolerance profile
 Identity
Transcutol® CG

INCI: Ethoxydiglycol
Description
Chemical name: Diethylene glycol
Dual nature
monoethyl ether
Small molecular weight hydrophilic and lipophilic

Dual nature: lipophilic and hydrophilic

 Solubilization
of both hydrophilic and
lipophilic materials
 Goodaffinity with the stratum
corneum

Oxygen – Carbon – Hydrogen

 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Process
Goal: 100% purified grade

1st distillation to 2nd distillation to

purify deodorize

Several in-process controls

Highly purified solvent

Process
Goal: 100% activity

Purity > 99.5%

 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Mode of action
Optimization of the efficacy of numerous actives

“Pull-effect”
“Push-effect” Strong affinity with the
Capacity to solubilize Powerful Diffusion lipids of the stratum
lipophilic actives in solubilizer enhancer corneum
polar solvents Vehicle the actives
inside the skin

Diffusion of actives Transcutol® CG

through the skin

(Mura P. et al., 2000;Yazdanian M. et al., 1995;Watkinson A.C., Hadgraft J., and Bye A., 1991;Rojas de Garcia J., 1991a)
 Mode of action
in vitro substantiation – Interaction with hair internal proteins

Aim

Split-end formation is due to structural changes of hair matrix proteins.

Verification of the ability of Transcutol® CG to interact with hair internal proteins and then
inhibits split-end formation.

Method

Measurement of hair split-ends formation of permed hair with an auto-

brushing machine (accelerative method close to the actual hair care
process): Inhibition
+20 % vs.
1. Permed hair treated 30 min w/wo various solvents with low
glycerin
molecular weights (ethylene glycol, glycerol, glycinebetaine, D-
panthenylalcohol, ethyl alcohol, urea) before a 60 min brushing.

2. Measurement of hair diameter by laser external-diameter

apparatus.

Results

Vs. other solvents, diethylene glycol monoether (Transcutol® CG) is the most effective in
inhibiting split-end generation of permed hair.
Transcutol® CG can interact with hair internal proteins.
 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Clinical evaluation
Self tanning efficacy booster

Aim

Evaluation of the intensity and duration of skin

color produced by DHA.

Method

1. Single application on the back of 10

volunteers of 2 spray formulas w/wo 20%
Transcutol® CG [both formulas contain 5%
DHA].
2. Measurement of skin color by chromametry
at T0, T3, T5, T24, T48, T72 hours after
application.
3. Use of the parameters L, a, b to calculate
ΔE = √(Δa2 + Δb2 + ΔL2) and comparison of
the results.

Results

Transcutol® CG gives a more rapid, more intense and longer-lasting tan.

 Clinical evaluation
Improvement of hair coloring

Aim

Evaluation of the influence of Transcutol® CG on the intensity and duration of hair color
after application of dye creams

Method

1. Single application of 2 semi-permanent dye

creams on natural, light brown hair locks,
w/wo 5% Transcutol® CG. *
2. Hair locks are rinsed with water, then color is * *
measured by chromametry.
3. Then, 4 times, shampoo is applied, followed
by chromametic measurement.
4. Calculation of ΔE = √(Δa2 + Δb2 + ΔL2) and
comparison of the results.

Results

Transcutol® CG improves fixation of dye on the capillary fibers and enables to have a
longer-lasting and more uniform color
 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Formulation & Regulation
Safety

Transcutol® has been used in

the pharmaceutical industry for
over 40 years and has an
excellent safety profile

 Ocular irritation (single application of 0.1 ml of pure product): non-irritant (score = 9.00).

 Acute oral toxicity (single oral administration of the pure product at a dose level of 5,000
mg/kg): non-toxic (LD50 > 5,000 mg/kg).

 Primary cutaneous irritation on humans (single application of pure product under occlusive
patch for 48 hours): non-irritant.

 Cutaneous sensitization on humans (9 successive applications of pure product under

occlusive patch for 48 hours over a 3-week period 14 days of rest—challenge application):
non-irritant and non-sensitizing.

 Dermal toxicity by repeated applications for 28 days (daily application under patch for 6
hours/day for a 28-day period, at levels of 100, 300 and 1,000 mg/kg/day): non-toxic.
Formulation & Regulation
Formulation

o Recommended use level: 2-30%*

 Soluble in water
 Soluble in alcohol
 Insoluble in oils

o Process:
 Slowly add the active to the
Transcutol® CG
 Mix until the active is completely
dissolve

o Add Transcutol® CG at a temperature < 50°C

(risk of oxidation above)

*see restricted use levels in Europe

Formulation & Regulation
Regulatory status

o Worldwide regulations
 Worldwide approval (restricted use levels in Europe)
 China: listed IECIC 2014-06
 Australia TGA
 Japan QD

o Restricted use levels in Europe:

 Rinse-off products: up to 10%
 Oxidative hair dye formulations: up to 7%
 Non-oxidative hair dye formulations: up to 5%
 Spray products, fine fragrances, hair sprays,
antiperspirants/deodorants: up to 2.6%
 All cosmetic products: up to 2.6%
 Applications

Identity

Formulation &
Regulation
Transcutol® CG Process
Ethoxydiglycol

Clinical
evaluation Mechanism
of action
 Applications
Sunscreens

Optimized UVA protection

Commonly used sun filter: Benzophenone-3
 Crystalline powder with a tendency to crystallize
out of many formulations, especially when < 3%
in low oil content formulations

 Transcutol® CG minimizes crystallization and

increases efficacy

Optimized UVB protection

Commonly used sun filter: Octyl Methoxycinnamate (OMC)
 In non-polar solvents, the UV curve of OMC will shift to a shorter wavelength

 With Transcutol® CG, the UV curve of OMC remains centered at 308 nm  in

sunscreen formulations with a low polarity oil vehicle, Transcutol® CG will increase
the polarity of the medium

Sensoriality
 Transcutol® CG helps to reduce the oiliness of the sunscreens
 Applications
Toiletries

Antiperspirants
 Transcutol® CG improves skin feel and decreases
tacky feel

 Transcutol® CG facilitates aluminum

chlorohydrate dispersion and then increases
efficacy

Soaps
 Transcutol® CG decreases the dissolution time of Triclocarban, antimicrobial active

 Transcutol® CG improves its uniform distribution throughout the soap

 Applications
Others

o Odorless solvent for perfume

extraction
 Superior solubilizing properties
 Olfactive neutrality
 Low irritation potential
 Solubilization of essences and aromatic
compounds

o Anti-acne preparations
 Solubilization of Benzoyl peroxide to avoid
grinding of this potentially explosive oxidizing
agent, and avoid grainy and scratching
sensation

o Co-surfactant for microemulsions

Applications
Transcutol® CG

Applications
 Compatible with all types of formulations

Specific applications
Skin Care:
 Anti-acne preparations
Sun Care:
 Sunscreens

 Self-tanning products
Hair care:
 Conditioners

 Hair dyes
Toiletries:
 Antiperspirants

 Antimicrobial soaps
Transcutol® CG
INCI: Ethoxydiglycol

Key features:

o Efficacy booster

o Powerful and versatile solubilizer

o High purity (> 99.5%)

o Excellent tolerance profile

o Compatible with all types of
formulations