SCHOOL OF MEDICINE

Department of Medicine
Clinical Pharmacology
Drug Interactions Flockhart Table ™
This site is dedicated to the memory of a pioneer in clinical pharmacology and
pharmacogenetics and the creator of this site/page, Dr. David A. Flockhart, MD, PhD
<https://drug-interactions.medicine.iu.edu/Memoriam.aspx>

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Substrates

1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A457

               

artemisinin amodiaquine amitriptyline acetaminophen

acetaminophen amitriptyline
bupropion cerivastatin atomoxetine aniline

alprenolol
amitriptyline capecitabine
cyclophosphamide
dabrafenib brivaracetam benzene

amitriptyline
apremilast celecoxib
efavirenz enzalutamide carisoprodol chlorzoxazone

amphetamine
caffeine clopidogrel abemaciclib
ifosphamide olodaterol chloramphenicol enflurane

/
clomipramine ketamine paclitaxel diclofenac citalopram aripiprazole ethanol acalabrutini

clozapine meperidine ponatinib doxepin clomipramine atomoxetine halothane alectinib

cyclobenzaprine
methadone repaglinide fluoxetine clopidogrel brexpiprazole isoflurane alfentanil

doxepin nevirapine selexipag fluvastatin cyclophosphamide

bufuralol methoxyflurane
alprazolam

duloxetine propafol sorafenib glibenclamide diazepam cariprazine n,n- amitriptyline

dimethylformamide

estradiol selegiline torsemide glimepiride doxepin carvedilol amlodipine

sevoflurane

fluvoxamine sorafenib glipizide escitalopram chlorpheniramine aprepitant

theophylline

haloperidol tramadol glyburide esomeprazole chlorpromazine aripiprazole

imipramine velpatasvir ibuprofen flibanserin citalopram astemizole

mexiletine irbesartan hexobarbital clomipramine atorvastatin

nabumetone lesinurad imipramine clonidine boceprevir

naproxen lornoxicam indomethacin codeine brexpiprazo

/
olanzapine losartan labetalol debrisoquine brigatinib

ondansetron meloxicam lansoprazole desipramine buspirone

phenacetin nateglinide moclobemide deutetrabenazine cafergot

pirfenidone olodaterol nelfinavir dexfenfluramine caffeine

pomalidomide ospemifene nilutamide dextromethorphan carbamazep

propranolol phenytoin omeprazole donepezil cariprazine

riluzole piroxicam ospemifene doxepin cerivastatin 

ropivacaine rosiglitazone pantoprazole duloxetine chlorphenira

rucaparib s- phenobarbitone
eliglustat cilostazol
naproxen

tacrine phenytoin encainide cisapride

s-
warfarin

tasimelteon pomalidomide escitalopram citalopram

suprofen

theophylline primidone flecainide clarithromyc

tamoxifen

/
tizanidine tolbutamide progesterone fluoxetine clopidogrel

triamterene torsemide proguanil fluvoxamine cobimetinib

verapamil valproic propranolol haloperidol cocaine

acid

warfarin r- ibrutinib codeine

venlafaxine mephobarbital

zileuton imipramine copanlisib

voriconazole r-
warfarin

zolmitriptan letermovir cyclosporine

zafirlukast
s-
mephenytoin
lidocaine daclatasvir

suvorexant
methoxyamphetamine dapsone

teniposide
metoclopramide deflazacort

tofacitinib
metoprolol dexamethas

venlafaxine
mexiletine dextrometho

voriconazole
minaprine diazepam

/
nebivolol diltiazem

netupitant/palonosetron docetaxel

nortriptyline domperidon

ondansetron doxepin

oxycodone efavirenz

paroxetine elbasvir/gra

perhexiline eliglustat

perphenazine eplerenone

phenacetin erythromyci

phenformin escitalopram

pimavanserin esomeprazo

pomalidomide estradiol

/
ponatinib felodipine

promethazine fentanyl

propafenone finasteride

propranolol flibanserin

risperidone gleevec

rucaparib haloperidol

sparteine hydrocortiso

tamoxifen ibrutinib

tetrabenzine idelalisib

thioridazine indinavir

timolol irinotecan

tramadol isavuconazo

/
umeclidinium ivabradine

valbenazine laam

venlafaxine lansoprazole

zuclopenthixol lenvatinib

lercanidipine

lidocaine

lovastatin

methadone

midazolam

naldemedine

naloxegol

nateglinide

/
nelfinavir

neratinib

netupitant/p

nevirapine

nifedipine

nisoldipine

nitrendipine

olaparib

omeprazole

ondansetron

osimertinib

palbociclib

/
panobinosta

pantoprazol

pimavanser

pimozide

progesteron

propranolol

quetiapine

quinidine

quinine

regorafenib

ribociclib

risperidone

/
ritonavir

rolapitant

romidepsin

salmeterol

saquinavir

selexipag

sildenafil

simvastatin

sirolimus

sonidegib

sorafenib

sunitinib

/
suvorexant

tacrolimus(f

tamoxifen

taxol

telaprevir

telithromyci

terfenadine

testosterone

torisel

tramadol

trazodone

valbenazine

/
 velpatasvir

vemurafenib

venetoclax

venlafaxine

verapamil

vincristine

voriconazole

zaleplon

ziprasidone

zolpidem

Inhibitors
Inhibitors compete with other drugs for a particular enzyme thus affecting the optimal level of
metabolism of the substrate drug which in many cases affect the individual's response to that
particular medication, e.g. making it ineffective.

/
 A Strong inhibitor is one that causes a > 5-fold increase in the plasma

AUC values or more than 80% decrease in clearance.

A Moderate inhibitor is one that causes a > 2-fold increase in the plasma

AUC values or 50-80% decrease in clearance.

/
 A Weak inhibitor is one that causes a > 1.25-fold but < 2-fold increase in

the plasma AUC values or 20-50% decrease in clearance.

TBD Inhibitor strength level is under review.

FDA preferred1 and acceptable2 inhibitors for in vitro experiments.*

1A2 2B6 2C8 2C9 2C19 2D6

           

amiodarone clopidogrel gemfibrozil amiodarone chloramphenicol  amiodarone

belinostat

/
cimetidine crisaborole glitazones capecitabine cimetidine  bupropion

letermovir

ciprofloxacin rucaparib clopidogrel citalopram  cimetidine

montelukast

perampanel
citalopram thiotepa crisaborole esomeprazole  cinacalcet

quercetin
crisaborole ticlopidine efavirenz felbamate  duloxetine

teriflunomide
efavirenz voriconazole fenofibrate fluoxetine  fluoxetine

/
fluoroquinolones trimethoprim fluconazole fluvoxamine  paroxetine

fluvoxamine fluvastatin indomethacin  quinidine1

furafylline fluvoxamine isoniazid  sertraline

interferon isoniazid ketoconazole  terbinafine

methoxsalen lovastatin lansoprazole celecoxib

luliconazole

/
mibefradil metronidazole modafinil

oritavancin

ribociclib omeprazole

paroxetine

rucaparib oral
contraceptives

simeprevir phenylbutazone
oritavancin

ticlopidine probenicid
oxcarbazepine

rucaparib
pantoprazole

/
sertraline probenicid

sulfamethoxazole rucaparib

sulfaphenazole ticlopidine

teniposide topiramate

voriconazole voriconazole

/
zafirlukast