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Osteomyelitis: Presentation by
Osteomyelitis: Presentation by
Presentation by : Dr.NIKHIL.S.U
Points of interest
Definition, Classification ,pathology, CF,
management based on classification
Chronic recurrent multifocal osteomyelitis
Mx, Rx
Acute hematogenous om, differences in
different age group
Sequestrum
ANATOMY
- Epiphysis
- Metaphysis
Histology of bone
• Basic structural unit of bone: Osteon/haversian
system
Components
a) Haversian canal d) Canaliculi
b) Lamellae e) Volkmann’s canal
c) Lacunae
HISTOLOGY OF BONE
1)Haversian canal:
- Present in centre of each haversian system.
- Canal consists of small artery, vein,
lymphatics,thin nerve fiber and supporting
tissues.
2)Lamellae
a) Concentric: thin plates of bony tissue, consists
of ground substance or matrix with collagen
fibers in calcified material.
b) Interstial tissue:
c) Circumferential lamellae: outer and inner
periphery of cortex.
3)Lacunae
-Small space between lamellae, each containing bone
cell osteocyte.
4)Canaliculi
-Fine radiating channels which connect lacunae with
each other and central haversian canal.
5)Volkmann’s canal
-Oblique canals running at right angles.
-Contain neurovascular bundles within
-Connect haversian canal with medullary cavity and
surface of bone.
PERIOSTEUM
Made up of
a) Outer layer of fibrous tissue.
b) Inner cambium layer:
- More vascular, cells with osteogenic potential
- Limiting membrane for bone and responsible for
periosteal osteogenesis.
- Attachments
ENDOSTEUM
- Lines walls of bone cavities including marrow spaces
forming inner limiting membrane
BLOOD SUPPLY OF LONG BONE
I) Nutrient arteries:
- Largely fed by arterial trunks.
- After entering diaphysis divides.
- Sends lateral branches in cortex, some to sinusoids.
- Anastmose with epiphyseal and metaphyseal
branches.
Medullay
vessels
INTRODUCTION
- Osteomyelitis is defined as inflammation of the bone & bone
marrow caused by infecting organism.
• Nelaton (1834) : coined osteomyelitis
• The root words are
osteon (bone)
myelo (marrow)
• these are combined with itis (inflammation) to define the
clinical state in which bone is infected with microorganisms
- Localized or involvement of all layers of bone.
- Difficult and challenging problem confronted by orthopedic
surgeons
- Currently morbidity and mortality has come down
- Key :early diagnosis and treatment.
- Multidisciplinary approach required.
Classification
IV) Weiland et al
Type 1:soft tissue infection
Type 2:circumferential cortical and endosteal infection.
Type 3:type 2 +segmental defect.
Cierny Mader staging system
Cierny-Mader classification
ANATOMIC TYPES
Physiological cont…..
A Host – With no systemic or local compromising
factor.
VI)Waldvogel’s classification
- Hematogenous
- Contiguous
- Chronic
D)Fungal:Actinomycetes,candidiasis,
aspergillosis,mucormycosis
E)Viral:LGV,Smallpox
Bacterial associations in specific clinical situations
1)Sickle cell anemia Salmonella
4)Diabetes: C.albican
5)Immunosupressive
therapy Fungi,M.avium complex
6)AIDS : Staph.aureus,
atypical mycobacterium
Modes of spread of infective foci
• Hematogenous spread- Usually involves the
meta physis of long bones in children or the
vertebral bodies in adults
Adoloscent
- MC by S.aureus.
- Also susceptible for infection with
N.gonnorhoeae involving skin, Joints.
- Vertebral bodies commonly involved, abscess spread
slowly and large sequestra may form.
- Destruction of cortical bone, which leads to
pathological fracture.
Clinical features
i) Negative
but may show soft
tissue swelling
ii) Skeletal changes such
as periosteal elevation after
10 days, lytic changes after
2-6 weeks
iii) Useful to look for anatomic
abnormalities
.
Sinography
Sinography can be performed
if a sinus track is present
Roentgenograms made in
two planes after injection of
radiopaque liquid into sinus.
Helpful in locating focus of
infection in chronic
osteomyelitis.
A valuable adjunct to surgical
planning
I) Three phase bone scan
99mTc-MDP
i) Increased uptake in all 3
phases of scan
ii) Highly sensitive(95%) in
acute infection.
iii) Poor in presence of
neuropathic arthropathy,
fractures,
tumour.
II) Gallium scan and indium
111labelled leukocyte scan used
in conjugation with technetium
scanning
MRI Scan
i) As sensitive as bone scan
ii) Detects changes in water
content of marrow before
disruption of cortical bone.
iii) IOC for vertebral OM.
“Any local swelling,or inflammation,painfulness and
restricted movement accompanied by fever should
elicit the tentative diagnosis of acute OM.”
Differential diagnosis
1) Rheumatic fever- gradual, joint swelling-poly
2) Ewing’s sarcoma- radiological signs
3) Acute suppurative arthritis- muscle spasm more
marked, limited mvts,effusion
4) Cellulitis- no intense pain
5) Erysipelas- raised red margins
Criteria for diagnosis in special instances
1) Bone aspiration yields pus;
2) Bacterial culture of bone or blood is positive;
3) Presence of the classical signs and symptoms
of acute osteomyelitis exists; and
4) Radiographic changes typical for osteomyelitis
occur.
MANAGEMENT
Treatment
-Appropriate treatment shortly after onset lowers
morbidity.
-In order to treat any sepsis, identify triggering
organism
-In some patients antibiotic treatment is doomed to
failure without surgical treatment.
-Bacterial screening starts with 3 blood cultures taken
at interval of 30 mins which gives 65% of isolating
organism
-Choice of antibiotic is based on highest bactericidal
activity, least toxicity and lower cost.
Nade’s principles of treatment of acute OM.
1)An appropriate antibiotic is effective before pus
formation.
2)Antibiotics do not sterilise avascular tissues or
abscesses,such areas require surgical removal.
3)If such removal is effective antibiotics should
prevent their reformation and primary wound
closure should be safe.
4)Surgery should not damage further already
ischaemic bone and soft tissues
5)Antibiotics to be cotinued after surgery.
Conservative management
- Analgesics and appropriate positioning(splinting).
- Supportive measures like IV fluids, blood
transfusion, high protein diet.
- Prerequisites for Antibiotics;
- Antibiotic selection: Drug which penetrates
infected tissues and attains sufficient levels in bone
and pus.
- Dosage should be 2-3 times the standard dose to
ensure peak serum bactericidal titre of 1:8 or
greater.
- If abscess not found, IV antibiotics to be started
based on gram stain.
- If gram negative, empirical antibiotic coverage for
most likely organism to be started.
- Under most circumstances most appropriate antibiotic is
semi synthetic penicillin(oxacillin/naficilllin) or 1st
gen.cephalosporins
- If allergic, clindamycin because of good intra osseous
penetration
- In children <3yrs,with anatomical/functional asplenia, in
whom pneumococcal infection is of concern, 3rd
generation cephalosporin is started
- In non-immunized Hib child, Cefuroxime or combination
of semi-synthetic penicillin/3rd gen cephalosporin would
be appropriate.
- In neonates addition of Aminoglycoside is necessary.
- Parenteral antibiotic continued till appropriate
clinical/lab response has occurred.
Switch to oral therapy
1)Clinical &lab improvement towards resolution.
2)Availability of oral agent tolerated by child
3)Likely compliance with antibiotic regime.
-Once oral therapy is initiated serum bactericidal
titres/serum antibiotic levels can be determined to
ensure effective dosing.
- Peak titre of 1:8 constitutes effective dosing.
-Serum bactericidal titres are assessed by drawing
blood 60-90 mins after 2nd or 3rd dose of antibiotic.
- When oral therapy not possible, out-patient
antibiotic therapy is initiated.
-End point of treatment: Recommended duration ranges from
4-8 weeks, but success has been reported with 23 days of
treatment.
-Tachdjian’s: Combined oral and IV for 6 weeks—
If it exceeds >12weeks,MRI to
R/O any surgically treatable cause
SURGICAL TREATMENT
Indications
a) Presence of an abscess requiring drainage
b) Failure of the patient to improve despite
appropriate antibiotic therapy in 24-48 hrs
- Objective of surgery is to drain any abscess cavity, all
non viable or necrotic tissue.
- When subperiosteal abscess found in infant,
several small holes drilled through cortex into
medullary cavity creating a small window.
- -Skin is closed loosely over drains and limb is
splinted.
- -Limb is protected for weeks to prevent
pathological fracture.
- -IV antibiotics to be continued.
Technique for drainage of acute osteomyelitis
TIBIA
- Tourniquet applied whenever possible, don’t
EXSANGUINATE if infection present.
- Make anteromedial incision 5-7.5cms over
affected part of tibia.
- Periosteum elevated,any compressed pus will
escape.
- Drill several holes 4mm through cortex into
medullary canal,if pus escapes drill to outline
cortical window and cortex removed with
osteotome.
- Evacuate any intra medullary pus and necrotic
tissue.
- Irrigate cavity with 3L saline with pulsatile
lavage system with antibiotics.
- Skin closed loosely over drains,do not close
wound if it produces excessive tension on skin.
After treatment
- Long leg posterior slab is applied with foot in
neutral position, ankle at 90 degrees, knee at
20 d flexion.
- Antibiotics continued based on culture
sensitivities
- Generally 6 week course of iv antibiotics given
- Orthopedic and infectious disease follow up
done for one year.
COMPLICATIONS
Early:
1) Septic arthritis.
2) Tenosynovitis.
3) Thromophlebitis, deep vein thrombosis
Antibiotics, surgical drainage, anticoagulation and assisted
ventilation.
4) Multiple pyogenic abscess.
5) Adverse reactions antibiotics.
Late
1) Chronic osteomyelitis
2) Pathological fracture
3) Local growth disturbances over growth-due to prolonged hyperaemia
4) Premature closure of epiphysis
5) Deformity
SUBACUTE OM
• Insidious onset, indolent course
• ESR - 50% ;
• Blood culture –Negative
Central metaphyseal
Eccentric metaphyseal
Diaphyseal cortical
Diaphyseal with
Ephyseal Metaphyseal and
periosteal new bone
epiphyseal
Cause of indolent course
• Low virulence bacteria
• Strong host response
• Antibiotics before symptoms
Change or Confirm
Stage 1 ( Based on culture results)
Cierny-Mader
classification
Poor response Good response ( After 48 hrs
Adequate treatment)
Operative Treatment
* Abscess drainage Continue 2 weeks parenteral
* Unroofing 4 weeks oral antibiotics
* I M Reaming
4 Weeks antibiotics
Failure Arrest
Retreat as above
Superficial Biopsy and Initial antibiotic +/- Local or
debridement Culture Selection microvascular
coverage
Stage 2
Cierny - Mader
Classification Change or confirm antibiotic
based on culture
Stabilisation
-External fixation Retreat as above
-Ilizarov technique