09/09/2021, 16:31 What is Seronegative Arthritis? Why is termed as a Fatal Condition?

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What is meant by Seronegative Arthritis?
Written by Team Dr Lal PathLabs

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History of the complaint, blood tests and imaging (X-rays/scans) are the basic diagnosis of any disease.

“Seropositive/ Seronegative” is a term that refers to the results of a blood test.

The question is does Seronegative rheumatoid arthritis exist?

CATEGORIES

A quick answer to this is YES. When a person tests negative for rheumatoid factor also known as RF and

Allergy
cyclic citrullinated peptides (CCP) and is a condition that is defined by painful and swollen joints that

occurs with age.

Anemia

Being seronegative means, you don’t have the anti-CCPs in your blood at all or not many of them. If you,
Arthritis

however, get a negative test for anti-CCPs and have RA symptoms then chances of being seronegative RA

Asthma
are higher.

Breast C
The basic difference between People with seropositive RA and seronegative kind is usually the

seropositive people have more pain and they are also more likely to:
CBC

Have nodules (swollen lumps under the skin) Dengue

Have vasculitis (inflamed blood vessels)

Diabete

Have rheumatoid lung issues

Have other illnesses along with their RA, like cardiovascular disease. Exercise

Smokers are at a high risk to get seropositive RA

First-Tri

Here’s a flowchart to show the classification of Arthritis- Food

For Doct

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09/09/2021, 16:31 What is Seronegative Arthritis? Why is termed as a Fatal Condition?

Genetic
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HbA1c

Heart

HIV / AID

Infertilit

Kidney

Lifestyle

Lifestyle

Liver

Lungs

Source- Doctors Gates

Malaria

It generally happens when the lining of your joints attacks one’s body immune system, this is most Medical

common among middle-aged women.

Neuroge

The term Seronegative is derived from the fact that a blood test that does not find an indicator to detect

Obesity
and results in a failed blood test where no RF and anti CCPs are found in the person’s blood, these are

the antibodies which are formed by the persons immune system which help attack the healthy tissues
Oncogen

in our body

Organ H

However, unlike other negative results, a  seronegative arthritis result can mean a positive diagnosis for

Pregnan
something else which is dangerous.

Press
If we look at the chunk of people suffering from arthritis, results have found that almost 71%-80% of

patients which show RS symptoms are Seropositive rheumatoid arthritis.

Second-

In the case of RA, early diagnosis is very important, the average time between the onset of symptoms
Standar

and diagnosis is 6-9Months, if the RA, however, goes untreated for 2 years there is a high possibility of

people developing joint erosion, indicating disease progression. Standar

Stress
The symptoms and course of RA may vary from person to person and can also change daily, but may

include:
Third-Tri

Thyroid

Vitamin

Vitamin

ARCHIVES

Source- Genentech, 2016

The patients who in turn depict seronegative results are unclear of their symptoms.

Key differences between people that are seropositive and seronegative?

There is have a higher chance of developing a more serious disease in a Seropositive patient, as they

are also more likely to have extra-articular complications (such as nodules and vacuities, swelling) than

those patients who are seronegative.

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09/09/2021, 16:31 What is Seronegative Arthritis? Why is termed as a Fatal Condition?
September 2

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July 2021

October 2020

June 2020

April 2020

February 202

December 20

August 2019

April 2019

January 2019

October 2018
Source- Medical Net, 2010

August 2018

However, being seropositive or seronegative does not the efficiency of most of the medicines.
June 2018

During the first six months of illness approximately half of RA patients are seronegative April 2018

February 201
However, study suggests that after 2 years of illness, only 15-20% of RA patients remain seronegative for

RF factor. December 20

October 2017
What are the treatments?

August 2017

Irrespective of the type of RA the treatment is likely to be similar

June 2017

Quoting a few below-

April 2017

February 201
An anti-inflammatory medication

A corticosteroid medication, December 20

A disease-modifying antirheumatic drug

October 2016

Physical therapy
August 2016

Hot water therapy

June 2016
Occupational therapy

Standing exercises April 2016

Surgery being the last resort

February 201

December 20
However, an essential point to make here is that these medications won’t cure your RA. They’ll just

make the symptoms easier to deal with, and slow down the growth and pain October 2015

August 2015
The best news about seronegative RA or seronegative spondyloarthropathy , seronegative arthritis is

that patients who have seronegative results in RF and anti-CCP testing tend to develop a less serious April 2015

joint disease and have fewer complications than those with seropositive results.
April 2014

March 2013

Types of Seronegative arthritis – September 2

January 2011
Ankylosing spondylitis– Low back pain and stiffness are the main causes. In severe cases, the

affected joints cause severe back stiffness. Other body parts such as chest wall, heels and hips

may also hurt. The symptoms in children however begin from the hips to knees and later reaching

the spine.

Reactive arthritis  – There is an acute pain in the sacroiliac joint that causes pain, swelling,

and  inflammation  of the joint. There may also be slight swelling in the fingers; however, the

reactive arthritis causes weight loss, skin irritation and fever.

Psoriatic Arthritis-  Is a form of arthritis that is linked to skin troubles known as psoriasis.

However, an important fact to notice here is that the severity of rash does not reflect the severity

of arthritis. There is also a thickening and yellow tinge around the fingernails and toenails and

joint troubles arise from the large joints such as hips and sacroiliac joints.

Enteropathic arthritis – Is a type of arthritis that occurs in the spinal cord that also

involves  inflammation  of the intestinal wall. This type of arthritis typically affects large joints,

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09/09/2021, 16:31 What is Seronegative Arthritis? Why is termed as a Fatal Condition?
such as the knees, hips,  ankles, and elbows. In children, the arthritis may begin before the

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The treatment has changed  through the years, so has the thinking  about RA in some cases. There is a

hope that a better understanding  of the differences between  the diseases we call RA may

provide  insights that could eventually lead to  new ways to treat and, perhaps in some  cases, even

prevent it.

Article Tags: arthritis · seronegative · treatment · types

Article Categories: Organ Health

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