Colegio de San Gabriel Arcangel

City of San Jose del Monte, Bulacan, Philippines

FULL NAME MENDEZ, PRINCESS GWENDOLYN B. SCO

RE
YEAR LEVEL BSP 2 DAT
E

LEARNING ACTIVITY FOR UNIT NO. 5

ANTI-MICROBIAL DRUGS

I. Matching Type:

A. Write the letter for the mechanism of action for each

antibacterial drug
1
. Erythromycin A. Inhibition of cell wall synthesis
2 Norfloxacin B. Inhibition of protein synthesis- binds to 50s ribosomal
. subunit
3 Streptomycin C. Inhibition of protein synthesis- binds to 30s ribosomal
. subunit
4 Clindamycin D. Inhibition of nucleic acid synthesis
.
5 Amoxicillin E. inhibiting the synthesis of essential metabolite
.
6 Bacitracin F. Injury to plasma membrane
.
7 Ciprofloxacin
.
8 Rifampicin
.
9 Cefalexin
.
1 Polymixin
0
.
1 Silver Sulfadiazine
1
.
1 Gentamycin
2
.
1 Chloramphenicol
3
.
1 Isoniazid
4

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.
1 Oxacillin
5
.
1 Vancomycin
6
.
1 Tobramycin
7
.
1 Clarithromycin
8
.
1 Cefixime
9
.
2 Tetracycline
0
.
B Write the letter for the mechanism of action for each
. antifungal drug
1 A. Agents inhibiting
. Miconazole nucleic acid
2 Flucytosine B. Agents affecting fungal
. cell wall
3 Fluconazole C. Agents affecting fungal
. sterols
4 Amphotericin B
.
5 Ketoconazole
.
6 Clotrimazole
.
7 Itraconazole
.
8 Terbinafine
.
C Write the letter for the f action for each Antihelminthic
. mechanism o drug
1
. Praziquantel A. paralyzes worm
2 Ivermectin B. inhibit absorption of nutrients
.
3 Mebendazole C. prevents ATP generation of
. mitochondria
4 Pyrantel pamoate D. alters permeability of plasma
. membrane

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5 Albendazole E. Neuromuscular block

.
D Write the letter for the source of microorganism for each antibiotic
.

1. Neomycin A. Penicillum griseofulvum

2. Eythromycin B. Streptomyces fradiae
3. Tetracycline C. Streptomyces erythraeus
4. Polymixin D. Bacillus subtilis
5. Bacitracin E. Streptomyces aurefaciens
6. Griseofulvin F. Streptomyces venezuelae
7. Penicllin G. Streptomyces nodosus
8. Streptomycin H. Streptomyces griseus
9. Amphotericin I. Bacillus polymixa
10. Gentamicin J. Penicillium notatum
K. Micromonospora purpurea

E. Write the letter for the mechanism of action for each antifungal drug

1. Miconazole A. Agents inhibiting nucleic acid

2. Flucytosine B. Agents affecting fungal cell wall
3. Fluconazole C. Agents affecting fungal sterols
4. Amphotericin B
5. Ketoconazole
6. Clotrimazole
7. Itraconazole
8. Terbinafine

F. Write the letter for the uses of each antimicrobial drug

1. Acyclovir A. treatment of leptospirosis

2. Silver sulfadiazine B. treatment of UTI
3. Metronidazole C. treatment for H1N1 virus
4. Clarithromycin D. treatment of chickenpox
5. Praziquantel E. effective against gram (+) bacteria
6. Chloroquine F. treatment of tapeworm
7. Rifampicin G. antibacterial for burnt patient
8. Neomycin H. treatment of upper respiratory tract
infection
9. Cephalosporin I. treatment for malaria
10. Penicillin J. treatment of intestinal roundworm
11. Clotrimazole K. effective against viral hepatitis
12. Griseofulvin L. treatment of tuberculosis
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13. Zidovudine M. topical drug effective against

Pseudomonas aeruginosa
14. Oseoltamivir phosphate N. treatment of wound infection for diabetic
patient
15. Clindamycin O. treatment for athlete’s foot
16. Ciprofloxacin – B P. effective against gram (-) bacteria
17. Mebendazole – J_ Q. treatment of wound infection applied
topically
18. Erythromycin – H R. antiretroviral for pregnant mother
19. Gentamycin – S. treatment of dermatophytic fungal
infection of hair and nails
20. Doxycycline – I T. treatment of amoebiasis
U. treatment for tonsillitis

G. Write the letter for the uses of each antimicrobial drug

1. Isoniazid – D A. antiretroviral for pregnant

mother
2. Silver sulfadiazine – G B. treatment of wound infection for
diabetic patient
3. Metronidazole – E_ C. treatment for H1N1 virus
4. Clarithromycin – D. treatment of tuberculosis
5. Praziquantel – K E. treatment of amoebiasis
6. Chloroquine – I F. treatment of dermatophytic
fungal infection of hair and nails
7. Oseoltamivir phosphate – G. antibacterial for burnt patient
8. Zidovudine – C H. treatment of upper respiratory
tract infection
9. Clindamycin – B I. treatment for malaria
10. Griseofulvin – J. treatment of intestinal
roundworm
K. treatment of tapeworm

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H. Write the letter for the source of microorganism for each antibiotic

1. Neomycin A. Penicillum griseofulvum

2. Eythromycin B. Streptomyces fradiae
3. Tetracycline C. Streptomyces erythraeus
4. Polymixin D. Bacillus subtilis
5. Bacitracin E. Streptomyces aurefaciens
6. Griseofulvin F. Streptomyces venezuelae
7. Penicllin G. Streptomyces nodosus
8. Streptomycin H. Streptomyces griseus
9. Amphotericin I. Bacillus polymixa
10. Gentamicin J. Penicillium notatum
K. Micromonospora purpurea

II. Discussions

1. Would there be any advantage to a soil microbe to produce an antibiotic?

2. Who coined the term chemotherapy?
3. More than half our antibiotics are produced by a certain genus of bacteria. What is it?
4. Why don’t penicillins affect the human cell?
5. Why do antibiotics that inhibit protein synthesis affect bacteria and not human cells?
6. Why do antibiotics that inhibit protein synthesis affect bacteria and not human cells?
7. Many antifungal drugs combine with sterols in the plasma membrane. Why don’t they
combine with sterols in human cell membranes?
8. What does semisynthetic mean?
9. How does a low concentration of penicillin G select for penicillin resistant bacteria?
10. What is penicillinase?
11. Would a β-lactamase effective against penicillin G be likely to affect cephalosporins?
12. What effect does the binding of chloramphenicol to the 50S portion of the ribosomes have
on a cell?
13. One of the most successful groups of antibiotics targets the synthesis of bacterial cell walls;
why does the antibiotic not affect the mammalian cell?
14. What phenomenon prompted the development of the first semisynthetic antibiotics, such
as methicillin?
15. What genus of bacteria has mycolic acids in the cell wall?
16. How do tetracyclines affect bacteria?
17. How do macrolides affect bacteria?
18. Of the three drugs often found in over-the-counter antiseptic creams—polymyxin B,
bacitracin, and neomycin—which has a mode of action most similar to that of penicillin?

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19. Why does erythromycin, a macrolide antibiotic, have activity limited largely to gram-
positive bacteria even though its mode of action is similar to that of the broad-spectrum
tetracyclines?
20. Define synergism.
21. What group of antibiotics interferes with the DNA-replicating enzyme DNA gyrase?
22. Both humans and bacteria need PABA to make folic acid, so why do sulfa drugs adversely
impact only bacterial cells?
23. Why do polyenes injure fungal plasma membranes and not bacterial membranes?
24. How do azoles affect fungi?
25. What sterol in the cell membrane of fungi is the most common target for antifungal action?
26. One of the most widely used antivirals, acyclovir, inhibits the synthesis of DNA. Humans
also synthesize DNA, so why is the drug still useful in treating viral infections?
27. Why are viral infections generally difficult to treat with chemotherapeutic agents?
28. What was the first drug for parasitic infections?
29. Which agent is the most effective against the bacterium being tested?
30. What is the MIC of this E test?
31. What is MIC?
32. In the disk-diffusion test, the zone of inhibition indicating sensitivity around the disk varies
with the antibiotic. Why?
33. This test used streptomycin and a gram-negative bacterium. What would the lines have
looked like if penicillin G had been the antibiotic?
34. How does this practice lead to development of resistant strains of pathogens?
35. What is the most common mechanism that a bacterium uses to resist the effects of
penicillin?
36. What would the plate look like if the two antibiotics had been antagonistic?
37. Tetracycline sometimes interferes with the activity of penicillin. How?
38. What are defensins?

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