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Topic 1.4 Biological Molecules Proteins 201805 Student
Topic 1.4 Biological Molecules Proteins 201805 Student
Global Edition
5
Biological Macromolecules and Lipids
Topic 1 Biological Molecules
(Protein)
Lecture Presentation by
Nicole Tunbridge and
Kathleen Fitzpatrick
Enzyme
Virus Bacterium
Transport
protein
Cell membrane
Insulin
High secreted Normal
blood sugar blood sugar
Muscle
30 µm
tissue
Receptor
Signaling protein
molecules
Collagen
Connective
tissue 60 µm
𝛂 carbon
X Y
1 5 10
Amino end
30 25 20 15
of transthyretin
acids
1 5 10
75
80 85 90
95
120 125
Carboxyl end
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Proteins
𝛂 helix
Hydrogen bond
𝛃 strand
Hydrogen
bond
𝛃 pleated sheet
Hydrogen
bond
Hydrophobic
interactions and
Van der Waals
interactions
Disulfide
bridge
Ionic bond
Polypeptide
backbone
Collagen
Heme
Iron
𝛃 subunit
𝛂 subunit
𝛂 subunit
© 2015 Pearson Education Ltd
𝛃 subunit
What’s the difference between the 2 structures below?
Polypeptide Chains
chain
Iron
Heme
α Chains
Collagen
© 2015 Pearson Education Ltd
Hemoglobin
Sickle-Cell Disease: A Change in Primary Structure
Secondary
Primary Quaternary Function Red Blood Cell
and Tertiary
Structure Structure Shape
Structures
1 Normal 𝛃 Normal Proteins do not associate
subunit hemoglobin with one another; each
2
carries oxygen.
3
𝛃
Normal
4
5 𝛂
6
7 5 µm
𝛃 𝛂
is reduced.
4
5 𝛂
6
7 5 µm
𝛃 𝛂
Term Definition