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Clinic Epidemiological Characteristics of Chronic Hepatitis C On The Background of Tuberculosis
Clinic Epidemiological Characteristics of Chronic Hepatitis C On The Background of Tuberculosis
Volume 5 Issue 5, July-August 2021 Available Online: www.ijtsrd.com e-ISSN: 2456 – 6470
@ IJTSRD | Unique Paper ID – IJTSRD45174 | Volume – 5 | Issue – 5 | Jul-Aug 2021 Page 1662
International Journal of Trend in Scientific Research and Development @ www.ijtsrd.com eISSN: 2456-6470
in patients of the 1st group was 1-3 years in 20% of was observed in 47.5% of patients in group 1, which
patients, 3-6 years in 47.5%, 6-9 years in 32.5% of turned out to be significantly more frequent than in
patients. In patients of the 2nd group, these indicators patients in the studied group 2 - 32.5%. Gum bleeding
were 1-3 years in 10% of patients, 3-6 years in 37.5% was revealed with almost the same frequency in both
of patients, 6-9 years in 52.5% of patients. Analysis studied groups - 12.5% and 15% in the first and
of the main clinical characteristics of co-infection second groups, respectively.
(TB + CHC) and the isolated course of CHC showed
Conclusion: The peculiarities of the course of CHC
that pain and severity in the right hypochondrium and
on the background of tuberculosis are of frequent
epigastrium were the most frequent symptoms and
occurrence in men, in the age group from 25 to 60
were observed with a frequency of 52.5% in group 1
years old, predominantly severe course of the disease
and 45% in group 2. Decreased appetite was also
is recorded, more often the presence of complaints
common in both study groups. Decreased appetite
and objective data associated with intoxication and
occurred significantly more often in the group of
cholestatic syndrome of moderate severity. With an
patients with concomitant TB and CHC (80%), in
increase in the duration of the course of the disease,
comparison with the isolated course of CHC (52.5%).
the risk of complications increases. The combination
Asthenovegetative syndrome was manifested by
of tuberculosis and liver damage of viral etiology is
weakness, lethargy, weakness and was recorded in
unfavorable and has a mutually aggravating effect.
70% of patients in group 1 and in 47.5% of patients in
Clearly marked changes in the liver often limit the
group 2. In all studied patients, changes in the
use of chemotherapy drugs necessary for controlling
digestive system were noted, which were manifested the tuberculous process.
by coated tongue, nausea, vomiting, hepatomegaly,
icterus of the skin and sclera of varying intensity, References:
darkening of urine. Thus, coating of the tongue was [1] Агравал П.Д. Особенности клиники и
detected in 55% of patients in group 1 and in 47.5% терапии вирусного гепатита при сочетании
of patients in group 2. Nausea and vomiting were его с туберкулезом легких: Автореф. дис. .
observed in patients in the group with a combined канд. мед. наук. Киев.
course of CHC + TBC with a frequency of 37.5%, [2] Витько Е.В. Эпидемиологическая
and in an isolated course of CHC with a frequency of характеристика вирусного гепатита С у
17.5%, which was significantly higher in the first больных туберкулезом легких. // Гепатит С.
studied group. Hepatomegaly was characterized by an /Тез. докл. 11 прак. конф. М., 2000.
increase and steady induration of the liver
parenchyma. At the same time, the lower edge of the [3] Brande P. Aging the hepatotoxicity of isoniazid
liver protruded from under the edge of the costal arch and rifampin in pulmonary Tuberculosis // Am.
by 1-4 cm; in all the patients under study, the J. Respir. Crit Care Med.
contours were smoothed without sharp deformation. [4] Ercilla M.G., Fortuny С., Roce A et al. Mother
In patients of group 1, this symptom was revealed to infant transmission of Hepatitis С virus a
more often (65%) than in patients of group 2 (45%). prospective study // Viral Hepatitis and liver
Disorder of bilirubin metabolism, which was disease.
characterized by icteric syndrome and a change in
urine color, manifested itself as icterus of the skin and [5] Елышн А.В., Ариэль Б.М., Нечаев В.В.
sclera of varying severity and intensity and was Диагностика гепатопатий у больных
recorded in 47.5% of patients in the 1st studied group туберкулезом легких // Проблемы
and in 37.5% of patients in the 2nd group. Pruritus туберкулеза.
@ IJTSRD | Unique Paper ID – IJTSRD45174 | Volume – 5 | Issue – 5 | Jul-Aug 2021 Page 1663