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DISTOCIDE

Composition
Each tablet contains:
Praziquantel 600 mg
(2-cyclohexylcarbonyl-1,2,3,6,7,11b hexahydro-4H-prazino-(2,1-a) isoquinoline-4-one.)

Properties and Mode of Action

DISTOCIDE, praziquantel causes vacuolisation of the syncytial distal tegument. At first, the vacuole is small but begins to
enlarge to form grossly recognizable bullae. The tegumental vacuoles finally burst leading to death of the parasites.

Indications
DISTOCIDE is uniquely effective against all human Schistosome species, liver and lung flukes as well as against a wide
range of tapeworms.

Dosage and Administration

Dosage must be adjusted to the individual case by the physician. If a dose is to be repeated on the same day, the interval
between each dose should be 4 - 6 hours. Tablets are to be swallowed with some liquid, unchewed and best after a
meal. One oblong tablet has four segments, each containing 150 mg active ingredient thus allowing easier and more exact
adjustment of the dosage to the patient's body weight. The number of tablets needed can be calculated as follows:
Parasite Recommended Dosage
Schistosoma haematobium 20 mg / Kg x2
S. mansoni 40 mg / Kg x1
S. japonicum 20 mg / Kg x3
Clonorchis sinensis 25 mg / Kg x3
Opisthorchis viverrini 25 mg / Kg x3
Paragonimus westermani 25 mg / Kg x 3 for 2 days
Hymenolepis nana 25 mg / Kg x1
Taenia saginata and Taenia solium 10 mg / Kg x1
Diphyllobothrium latum 25 mg / Kg x1
Cysticercus cellulosae 25 mg / Kg x 3 for 4 days

The number of tablets needed can be calculated as follows:

Body weight No. of tablets Body weight No. of tablets
( Kg ) (= 20 mg/Kg) (Kg) (= 25 mg/Kg)
20 - 26 3/4 22 - 26 1
27 - 33 1 27 - 33 1 1/4
34 - 41 1 1/4 34 - 38 1 1/2
42 - 48 1 1/2 39 - 44 1 3/4
49 - 56 1 3/4 45 - 50 2
57 – 63 2 51 - 56 2 1/4
64 - 70 2 1/4 57 - 62 2 1/2
71 - 78 2 1/2 63 - 68 2 3/4

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79 – 86 2 3/4 69 - 75 3

Side effects

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