DuPont™ Altacor™ 34.

9WG

Powered by DuPont™ Rynaxypyr®

Physical and Chemical Properties
• Brand name: DuPont Altacor 34.9WG
• Active ingredient: Chlorantraniliprole 34.9%

• Chemical Class: Anthranilic diamide

• ISO Common Name: Chlorantraniliprole
• Trade Name (Tech.): RynaxypyrTM
• Mode of Action: Ryanodine receptor activator
• Structural Formula: H Br
O
HC N
3 H N
N N
Cl
O
Cl CH N
3
• Solubility in Water: 1.0 mg/L at 20°C
• Volatility: Not volatile 2

12/11/2014
 Mode of Action Overview

• Novel Chemistry:
- Anthranilic diamide

• Novel Mode of Action:

- Activates ryanodine receptors (RyRs), causing
muscle paralysis (RyR “activator”)

• Excellent Safety in Mammals

- Selective for insect RyRs
3

12/11/2014
 Unique Biochemical Target
Different from all other commercial insecticides, RynaxypyrTM acts on a unique
biochemical target within insect muscle cells
Organophosphates ATP Synthase Inhibitor:
Central/Peripheral Carbamates Diafenthiuron Muscle
Nerve Fiber
Neonicotinoids,
Cartap, Bensultap

Sodium
channels

AChE Inhibitor

Acetylcholine GABA gated

Receptors antagonist chloride channel

Motor Nerve Ryanodine

Receptors
Antagonist: Endosulfan, Fipronil
Modulator: Pyrethroids Activator: Abamectin, Emamectin
Blocker: Indoxacarb, 4

Metaflumizone
Rynaxypyr™ 12/11/2014
What is the Ryanodine Receptor (RyR)?

• RyRs play a critical role in muscle

contraction Cell

• The RyR is a membrane-bound

protein localized in the sarco- RyR RyR

endoplasmic reticulum of muscle and

nerve cells
calcium
ions
• The RyR channel regulates release of Calcium
Store

stored calcium into the intracellular

space

12/11/2014
How Does It Work?
RynaxypyrTM Activates Insect RyRs
• Binding of Rynaxypyr™ to Heart of larval M. sexta
the RyR causes the receptor
channel to open for
prolonged periods of time.

• Uncontrolled release of
calcium ions depletes the
internal calcium stores.
Subsequently the insect is
unable to produce muscle
contractions  Paralysis
Click on icon 
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to start video ..\KNOWLEDGE

TRANSFER JUNE 26 12/11/2014
2007\heart4.mpg
 DuPont Rynaxypyr™
Effects on Insect Muscle
Action potential triggers brief RyR openings
Release of Ca2+ muscle contraction
Excitatory
Rynaxypyr™ nerve
Action potential

Ca2+ ions Sarcoplasmic

reticulum
Ca2+ store
Ryanodine Receptor VG Ca2+ channel

closed
empty

muscle
fiber closed
Ca2+ release
closed
empty
closed
empty 7

closed
empty
12/11/2014
Contraction
contraction
& Paralysis
 Mode of Action Summary
• Novel mode of action
- Potent activator of insect ryanodine receptors (RyRs)
- Depletion of internal calcium stores leads to insect paralysis/death

• Selective for Insect Ryanodine Receptors

• Mode of action shared with flubendiamide

- Flubendiamide shares binding site
- Distinct structural classes

• Excellent offering for resistance management

- Novel target and chemical class 8

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 BIOLOGICAL ATTRIBUTES
• Rapid feeding cessation (7 minutes) TREATED
 General lethargy
 Regurgitation
 Muscle paralysis
 Severe growth stunting

• Relatively slow death (within 72

hours)
• Activity by ingestion. (Thorough
foliar coverage is important) UTC
Photos. R. Armstrong

• Rainfastness: 1.0 hour Helicoverpa zea larvae

• Ovi-larvicidal activity (potent

larvicide and will control neonates
as they ingest the corion to eclode
from the egg
 Mammalian Toxicology

• No adverse effects have been observed:

• No acute oral, dermal and inhalation toxicity
• No skin and eye irritation; no skin sensitization
• No mutagenicity
• No carcinogenicity
• No subacute and subchronic toxicity in rats, mice and dogs
• No reproductive and developmental toxicity
• No neurotoxicity
• No immunotoxicity
• No chronic toxicity

• Conclusion: No adverse effects were observed in any

Rynaxypyr™ mammalian toxicology study, even at the
highest dose levels required by regulatory agencies
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Field Application
 DuPont Altacor 34.9WG for
Oil Palm Pest control

Bunch moths - Tirathaba

Leaf eater – Spodoptera
Bagworn – Psychidae
Nettle caterpillar - Limacodidae
 DuPont Altacor 34.9WG for Tirathaba control

Benefits:
1. Effective control on
Tirathaba
2. Long Duration of Control
(upto 3-6 months)
3. Does not affect newly hatch
pollination weevil. Only
effective on Lepidoptera.
Tirathaba mundella
 Tirathaba mundella: Life cycle

• Adult: 14 days

• Egg: 4 days (???)

• Larvea: 16 days (5 instars)

• Pupae: 12 days

Total: 30 – 45 days
Normal OP Fruit Bunch Development
Infested OP Fruit Bunch Development
 Result
Treated with Altacor

Untreated
 Possible impacts of Tirathaba

• Losses of crop up more than 50% due to:

• Small fruit bunces/malformed bunces
• Thin mesocarp, lower OER
• Non formation of kernel
• Abortion of bunches
• High Free Fatty Acid (FFA)

… Lim KH (2012)
Treated with BT Treated with Altacor

Untreated

Yield improvement: 3x(?)

 Altacor vs. BT

Altacor: 85g/ha x 2 rounds @14 days interval BT: 1.5L/ha x 2 rounds @10 days interval
 Effect on Weevil (Elaeldobius kameruncus) & Earwig
(Chelisoches morio) & other Beneficial Insects

Earwig
pollinating weevil (Chelisoches moris)
(Elaeidobius kameruncus)
 Wrong choice of chemicals

Malformed bunches Cypermethrin spraying affected

No weevils the population of pollinating
Parthenocarpic fruitlet weevil (Elaeidobius kameruncus).
… Lim KH (2012)
Concern: Crop loss
 Spodoptera issue

• Immature palm
• Newly planted to 2 years old
• Also reported in the main nursery
Life cycle: 29 days – 35 days
2-3 days

6 instars (12-17 days)

7 - 9 days

8-11 days
 Spodoptera litura: On OP

Spodoptera litura
Spodoptera litura: Symptom
 Issue:

• Previous practice: Cyper H2O (20%) / Cyper (4.6%)

+Chlopyrifos (45.9%)
• treatment: 5 days interval
- labour intensive
- unable to cope
- resistance
 Recommendation

• Altacor: 85g/ha
• Miracle S240 – 100ml/ha
• 2 rounds spray in 14 days interval / campaign
Spray with Mist Blower

Mist Blower Setting:

Spray vol = 114L/b.ha
Coverage = 40 palms/12L
Rate: 85g/b.ha
Dosage: 14g/12L pump

Miracle dosage
4ml / 12L pump
 Spodoptera treatment : Results 2WAA
Treated Altacor Treated cyper + chlopyrifos
 Other Pests
Bagworm (Psychidae)
• Bagworm is one of the most destructive pests in Malaysia’s
oil palm plantations. About 33-40% of crop loses can be
caused by bagworm infestations (Basri, 1993)
• 3 major species: Metisa plana, Mahasena
corbetti and Pteroma pendula

Metisa plana Mahasena corbetti Pteroma pendula

Bagworm Treatment
Altacor rate: 30g/ha – 85g/ha
Nettle catepillar
(Thosea assygna)
Altacor rate: 30g/ha
The challenge
“Supreme excellence consists of
breaking the enemy’s resistance
without fighting”

- Sun Tzu (6th century BC),

The Art of War Thank you