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Ibuprofen
Ibuprofen
[Adavan, Yzel]
[Bahjin, Dayang Fhernea]
[Busmion, Kristel Jade]
[Caylan, Dimple Grace]
[Esguerra, Karen Joy]
[Lee, Stephanie]
[Paul, Rica]
[Somoso, Mechiel]
Flyleaf…………………………………………………………………………………I
Cover Page……………………………………………………………………………II
Introduction.......................................................................................................................1
a. Implementation.......................................................................................................1.1
b. Pharmacokinetics...................................................................................................1.2
c. Pharmacodynamics................................................................................................1.3
d. Interactions.............................................................................................................1.4
Drug Study.........................................................................................................................3
References........................................................................................................................14
Illustrations (Figures/Tables).........................................................................................15
Introduction
a. Implementation
These drugs are used for the management of mild to severe pain, dysmenorrhea, and
topically or depends on the one who takes it. Ibuprofen tablets and capsules should be
taken with food or a glass of milk to minimize the risk of an upset stomach. Ibuprofen is
often used in doses of 200- 400 mg every 4-6 hours as needed. It can take around 20 to
30 minutes to take effect orally and parentally and roughly 1- 2 days when applied on the
skin.
b. Pharmacokinetics
Oral ibuprofen absorption is rapid and complete. Adults quickly absorb ibuprofen from
600mg, the unbound fraction increases, resulting in increased ibuprofen clearance and
action for nonsteroidal anti-inflammatory drugs. Orally, it is well absorbed and reaches
peak serum concentration in 1–2 hours. When ibuprofen is taken immediately after a
Ibuprofen has a volume of distribution of 0.1 L/kg. The binding of ibuprofen to plasma
proteins and purified albumin appears to be saturable and non-linear at doses over 20
1
Ibuprofen is almost completely metabolized, with little to no unchanged drug found in
the urine. This accounts for more than 90% of the administered dose. It is eliminated 24
hours after the last dose, and almost all the administered dose goes through metabolism,
representing about 99% of the eliminated dose. The two main metabolites, carboxy-
ibuprofen, and 2-hydroxy-ibuprofen (and their acyl glucuronides) are excreted in the
urine in ~37 and 25% of a given dosage, respectively. Other hydroxylated metabolites
(3-hydroxy- and 1-hydroxy-ibuprofen) were found in urine. Hepatitis and cystic fibrosis
may affect ibuprofen disposition kinetics. Ibuprofen is not excreted in large amounts in
The serum half-life of ibuprofen is 1.2-2 hours. This can be prolonged to 3.1-3.4 hours in
individuals with compromised liver function. However, several studies have shown that
young children (0.5–5 years) had greater rates of ibuprofen clearance. Its half-life in
developmental effects on CYP enzyme activity and lower glomerular filtration rates than
in adults.
c. Pharmacodynamics
Ibuprofen has several actions in various inflammatory pathways that are involved in both
acute and chronic inflammation. The major effects of ibuprofen have been linked to the
control of pain, fever, and acute inflammation via the inhibition of prostanoids
The antipyretic action is related to prostanoid production, as prostanoids are the primary
body temperature).
managing dysmenorrhea, where it has been shown to decrease menstrual prostanoids and
2
uterine hypercontractility. Additionally, it has been shown to lessen the fever and pain
a. Interactions
Increase: bleeding risk—valproic acid, thrombolytics, antiplatelets, anticoagulants,
salicylates, SSRIs
LAB VALUES: May prolong bleeding time. May alter serum glucose level. May
increase serum BUN, creatinine, potassium, ALT, AST. May decrease serum calcium,
Drug Study
acid pathway.
3
Ibuprofen is a non-selective COX inhibitor, which means that it suppresses
both COX-1 and COX-2 activity. Inhibiting COX-2 activity reduces the
(the blood vessel that connects the main pulmonary artery to the proximal
descending aorta) fails to close after birth, causing severe risk of heart failure.
disorders.
Cystic fibrosis - the use of high dosages of ibuprofen has been proven to
lungs.
antagonize the effect of diuretics which has been reported to be beneficial for
Dental pain - ibuprofen is used to manage acute and chronic orofacial pain.
Minor pain - ibuprofen is widely used to reduce minor aches and pains and
reduce fever and manage dysmenorrhea. It is very commonly used for the
4
Investigational uses - efforts have been put into developing ibuprofen to
elevated total bilirubin, congenital heart disease in whom patency of the patent
HF, CCr <25 mL/min Cautions: Pts with fluid retention, H.F., dehydration,
history of G.I. disease (e.g., bleeding, ulcers), smoking, use of alcohol, elderly,
5
anemia, aplastic anemia, eosinophilia, hemolytic anemia, leukopenia,
d. Nursing Responsibilities
Advise patient to take the medication with food or immediately after meals to
glass of water and refrain from lying down for 15 to 30 minutes to avoid
esophageal irritation.
Advise patient not to take the medication in higher dosages or for a longer
risk of MI or stroke.
Instruct patient to consult prescriber if he needs to take the drug for more than
3 days for fever or 10 days for pain; if stomach problems recur; history of
Inform the patient that the full therapeutic effect of arthritis may take up to two
directed, and alert prescriber if the patient has ever had an adverse reaction to
6
Instruct the patient to abstain from alcohol, aspirin, and corticosteroids while
If the patient takes aspirin to prevent MI or stroke, inform them that ibuprofen
Urge parents to tell the prescriber promptly if the child receiving the drug
child with asthma, bleeding issues, heart or kidney disease, high blood
Caution pregnant patients not to take NSAIDs such as ibuprofen during the
last Trimester because they may cause premature closure of the ductus
arteriosus.
Alert patient to rare but severe skin reactions. Urge him to seek immediate
hypersensitivity.
7
a. Assessment
Subjective:
Objective:
Pain scale 7/10, With a facial grimace, Restlessness, Sweating, VS 120/80, 85,
19 PS 6/10
b. Diagnosis
c. Planning
d. Nursing Interventions
Independent:
Dependent:
e. Rationale
8
To determine the nursing care to be given to the patient.
pain/promoting comfort.
e. Evaluation
After four (4) hours of nursing interventions, the goal was met.
The patient verbalized relief from pain, and there are no non-verbal indicators of
pain/discomfort present.
a. Assessment.
Subjective:
Objective:
Facial grimace
Guarding behavior
Limited mobility
Vital Signs:
B.P.- 126/75
9
H.R.- 84 bpm
R.R.- 20 cpm
b. Diagnosis
c. Planning
activities.
d. Nursing interventions:
The patient will take Ibuprofen 200mg every 4-6 hours as needed as per
Observations over the level of pain, and motor response, an hour after
drug administration.
Have the patient perform the activity more slowly, in a long time with
e. Rationale
10
The assessment will provide optimal nursing objective data to prevent
f. Evaluation
The goal was fully met after 4 hours of nursing interventions. The patient
verbalized a decrease in pain on a pain scale of 2/10 and can perform ADLs
a. Assessment
Subjective:
“Sakit akong likod dayon mag ngolngol” as stated by a 50yr old woman.
Objective:
Facial Grimace
Poor Posture
Vital Signs:
B.P.: 125/80
H.R.: 86
R.R.: 19
11
b. Diagnosis
c. Planning
activities of daily living and desired activities; the patient's back pain will reduce.
d. Implementation
Administer 400mg ibuprofen orally every 4-6 hours as needed for pain,
e. Rationale
Staying in bed for an extended amount of time can cause stiffness and
soreness.
f. Evaluation
12
Within 4 hours of nursing interventions, the goals were met as evidenced by:
13
References
https://www.medicinenet.com/ibuprofen/article.htm#what_is_ibuprofen_advil_m
otrin_nuprin_and_how_does_it_work
from. (https://www.nhs.uk/medicines/ibuprofen-for-adults/
Hodgson & Kizior (2021) Saunder’s Nursing Handbook Elsevier 3251 Riverport
Lane St. Louis, Missouri 63043
14
Illustrations (Figures/Tables)
Drug Study
15
Rheumatoid- and osteoarthritis - ibuprofen is very
orthostatic hypotension.1
16
satisfactory pulmonary or systemic blood flow (e.g., pulmonary
17
wheezing Skin: Blisters, erythema multiforme, photosensitivity,
esophageal irritation.
MI or stroke.
the drug for more than 3 days for fever or 10 days for pain; if
18
patient has ever had an adverse reaction to any other
asthma.
prescribed.
diuretic medication.
19
pain, edema, shortness of breath, slurred speech, limb
grounds.
20
BP: diminished n conditio present.
120/80 or absent techniqu n of the
H non-verbal es such patient.
indicators. as deep To
.R.: 85 breathing promote
R.R.: 19 exercises comfort
Pain . and
scale of 6 relaxatio
out of 10 Dependent: n.
Adminis To help
ter pain relieve
medicati the pain.
ons as To add
ordered. comfort
to the
patient.
They
serve as
non-
pharmac
ological
methods
of
reducing
pain/pro
moting
comfort.
21
behavior client's abdomina self-care
verbalized l cramps. activities.
Lack of decreased Massag
effort when level of pain e the May
standing or and abdomi reduce
engaging in discomfort nal area pain due
activities. during that to the
activities. feels stimulus
Limited pain. of
mobility therapeuti
c touch.
Vital Signs:
o B.P.-
126/75 The For pain
o H.R.- patient relief.
84 will
bpm take
o R.R.- Ibuprof
20 en
cpm 200mg
every 4-
Pain scale 6 hours
of 8 out of as
10. needed
as per
doctor’s
order
for
pain.
The
Observa assessme
tions nt will
over the provide
level of optimal
pain, nursing
and objective
motor data to
respons prevent
e, an possible
hour complicat
after ions and
drug appropriat
adminis e
tration. interventi
ons.
It helps in
increasing
the
22
tolerance
for the
Have activity.
the
patient
perform
the
activity
more
slowly,
in a
Rest
long
between
time
activities
with
provides
more
time for
rest or
energy.
pauses,
or with
assistan
ce if
necessa
ry.
Encoura
ge
adequat
e rest.
23
Nursing Care Plan #3
Assessment Nursing Planning Nursing Rationale Evaluati
Implementati on
Diagnosis on
SUBJECTI SHORT
VE: TERM
Impaired GOAL: Monitor To have an idea Within 4
physical the daily on how to lessen hours of
mobility routine of back pain. nursing
“Sakit akong related to the intervent
likod dayon back pain. After 4 hours patient. ions, the
mag of nursing goals
ngolngol” as interventions, To increase
Maintain blood flow and were met
stated by a the patient as
light ease the pain.
50yr old will be able activity, evidence
woman. to participate such as d by:
in activities walking.
of daily Staying in bed
living and for an extended
desired Encourag amount of time • Patient
OBJECTIV actions; the e the can cause was able
E: patient’s back patient to stiffness and to
limit bed soreness. participat
pain will
Facial rest. e in
reduce.
Grim
Increase chances ADLs
ace
Poor of being able to and
Postu manage the pain. desired
re activities
Vital Signs Teach .
significant
BP: others
125/8 about
non- •
0
H pharmacol Patient’s
.R.: 86 ogical pain
ways to scale was
R.R.: lessen the
decrease
19 pain, such
as d from 7
Pain To relieve the
massage to 3 out
scale pain.
and of 10
of 7
out of applying
10 heat
compress.
Administe
r 400mg
ibuprofen
24
orally
every 4-6
hours as
needed for
pain,
prescribed
by the
doctor.
25