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Amish Genome Reading

In the heart of Pennsylvania is the Amish community composing of creative people

characterized by iconic handmade clothes and the horse–drawn carriages. The emergency of

modern medical technology has played a great role in the lives on many residents like the

Hoover’s family (Ali et al. 28). The Amish are at the forefront of genomic medicine because of

the major steps they undertook to better the healthcare institutions. They put up the clinic for

special children to work on DNA sequencing and personalized genomic medicine. This followed

the diagnosis of an Amish six–year old patient by Morton, who found out the kid had glutamic

type 1 (GA-1) caused by defect in enzymes that digest proteins.

Genomic medicine has built hope in diagnosis of rare diseases through genetic analysis

and establishment of any occurrences of gene mutation. For the first time in 2010, Rayon, son of

Leon and Linda Hoover got his mysterious illness diagnosed through genome sequencing. The

diagnosis process is always long and the invention of the thousand-dollar genome and million

dollar interpretation projects by Eric Toprol has aided to nature the cause and roots of DNA

variation (Garner, et al. 33). Inside the Amish and the Mennonite, we have an insulated

population that is less exposed to genetic mutation reducing the numbers of gene variation. The

established children clinic is not only a lab but also a good establisher of a cohesive community

relationship. It is easy to trace any forms of genetic variation because the history of families is
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well known. The researcher found it appropriated to study genetic mutation in an isolated

population.

Genomic medicine can help in saving lives of people diagnosed when they are below 24

years through transplanting of compatible bone marrow, the mutations can be isolated or

dissolved. Most genetic disorder makes the victim unable to fight various infections e.g. the

SCID (Garner, et al. 33). Besides this defects, Morton and Strauss examined patients from 27

more communities and uncovered around 15root causes of genetic disease. This was greatly

influence by tracing the founder population of a certain community and analyzing the trend in

genetic composition through genome sequencing.

Research shows that integration of clinic and the laboratory makes it easy for the

gnomists to establish the roots of genetic disorders. This is the major cause to the failure of the

million dollar project interpretation. The techniques employed by the clinic already work in the

middle East and Ireland for consagenious population (Ali et al. 28). To make sure the model of

the clinics become useful, it’s good to understand the gene pool of each population. To

demonstrate that mutations are the center for such incurable infections, a group of neuroscientists

are working together to find the biological sequences of mutations discovered by the established

clinics (Kovach et al 54). For the cases of Kendra Hoover, a human immunoglobulin injection

was delivered to stop emergence of any viral or bacterial infection as the transplanted cells help

develop a strong functional immune system.

Like a student of medical laboratory, the study of genomic sequencing and its important

role in discovering of mutation in the human sequence matters greatly. This is because it is clear

that there are many pending innovations and experiments as this only involved a closed
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population. The bigger challenge of discovering the history of genetic population in a free

population is still paramount. As mutations remain consistent, their futility stands at its worst.

Works Cited

Ali, Omar A., et al. "RAD capture (Rapture): flexible and efficient sequence-based genotyping."

Genetics 202.2 (2016): 389-400.

Garner, Brittany A., et al. "Genomics in conservation: case studies and bridging the gap between

data and application." Trends in ecology & evolution 31.2 (2016): 81-83.

Kovach, Ryan P., et al. "Vive la résistance: genome-wide selection against introduced alleles in

invasive hybrid zones." Proc. R. Soc. B 283.1843 (2016): 20161380.