1.

Title: Changes in Intraocular Pressure and Angle Structure after Dilation in Primary
Angle-Closure Suspects with Visually Significant Cataract
Contents: Dilation of primary angle-closure suspects with concurrent visually
significant cataract appears to have a low risk for intraocular pressure spike. Change
in anterior chamber depth was the main factor associated with postdilation pressure
elevation.
题目：明显白内障伴可疑原发闭角型青光眼散瞳后的眼内压及房角变化
内容：对于明显的白内障伴可疑原发闭角可青光眼的患者，散瞳后有较低的眼
压急速上升的风险，前房深度变化是影响散瞳后眼压变化的主要因素。

2.Title: Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer
Loss in a Large Clinical Population
Contents: In a longitudinal study involving a large clinical population, stricter
intraocular pressure control reduced the chance of fast structural loss from glaucoma.
These findings may guide clinicians in establishing target pressures in clinical
practice.
题目：大样本临床人群中眼压控制对视网膜神经纤维层丢失率的影响
内容：在一项涉及大样本临床人群的纵向研究中，更严格的眼压控制降低了青
光眼结构的快速丧失。这些发现可以指导临床医生在临床实践中建立目标眼压。

3.Title: Cardiovascular Disease Predicts Structural and Functional Progression in

Early Glaucoma
Contents: Cardiovascular disease, especially hypertension, is associated with macula
ganglion celleinner plexiform layer structural defects at baseline in glaucoma and
predictive of both structural and visual field progression in early glaucoma.
题目：心血管疾病预测早期青光眼的结构和功能进展
内容：心血管疾病，特别是高血压，与青光眼基线的黄斑神经节细胞丛状层结
构缺陷有关，并可预测早期青光眼的结构和视野进展。

4.Title: HAWK and HARRIER: Ninety-Six-Week Outcomes from the Phase 3 Trials
of Brolucizumab for Neovascular Age-Related Macular Degeneration
Contents: At 96 weeks, brolucizumab provides comparable vision gains to aflibercept,
with greater retinal fluid resolution and a high probability of remaining on an every-
12-weeks regimen from weeks 48 to 96.
题目：HAWK 和 HARRIER：Brolucizumab 对新生血管性年龄相关的黄斑变性
的 3 期临床试验的 96 周结果
内容：在 96 周时，brolucizumab 提供了与 aflibercept 相当的视力增益，同时又
很好的视网膜下液吸收以及在 48-96 周中有很大的可能保持每 12 周一次注射方
案。

5.Title: Multimodal Imaging of a Pigmented Vitreous Cyst

Contents: A 32-year-old man presented with a floater in his right eye of 1-day
duration. Examination revealed a visual acuity of 20/20 with a 2 disc-diameter,
pigmented, translucent, freely floating, oval cystic lesion in the midvitreous of the
right eye (Fig A, inset showing magnified view). Ultrasonography highlighted the
cystic nature of the lesion with an anechoic center and hyperechoic borders (Fig B)
with OCT showing a well-defined hyperreflective structure with a hyporeflective
lumen (Fig C). Infrared reflectance showed speckled hyperreflectivity, highlighting
the presence of melanosomes (Fig D), confirming the diagnosis of a ciliary body
epithelium derived pigmented vitreous cyst (Magnified version of Fig A-D is
available online at www.aaojournal.org).
题目：色素性玻璃体囊肿的多模成像
内容：一名 32 岁的男性主诉 1 天前右眼中出现了一个漂浮物。检查显示右眼中
部玻璃体直径为 2 个视盘直径，有色，半透明，自由漂浮的椭圆形囊性病变
（图 A），视力为 20/20。超声检查突出了病变的囊性，具有中心暗区和高回声
边界（图 B），OCT 显示明显的高反射结构和低反射腔（图 C）。红外反射显
示斑点的超反射性，突出了黑色素的存在（图 D），证实了从睫状体上皮衍生
的色素性玻璃体囊肿的诊断。
6.Title: Use of OCT Retinal Thickness Deviation Map for Hydroxychloroquine
Retinopathy Screening
Contents: The automatically generated retinal thickness deviation map of swept-
source OCT provided quick and objective assessment of retinal changes caused by
hydroxychloroquine toxicity. The map showed the potential to enhance
hydroxychloroquine retinopathy screening.
题目：OCT 视网膜厚度偏差图在羟氯喹视网膜病变筛查中的应用（羟氯喹是抗
疟药物，也是 COVID-19 期间获得过 FDA 紧急使用许可的药物）
内容：扫频 OCT 的自动生成视网膜厚度偏差图为羟基氯喹毒性引起的视网膜变
化提供了快速、客观的评估。 该图显示了增强羟基氯喹视网膜病变筛查的潜力。

7.Title: Successful Strategic Management of Pythium insidiosum Keratitis with

Antibiotics
Contents: Management of Pythium insidiosum keratitis has several challenges due to
the lack of information related to its clinical and microbiological features and
availability of efficacious medical treatment. Except for a few anecdotal case reports,
most of the studies recommend early therapeutic penetrating keratoplasty (ThPK) as
the primary line of management. However, the recurrence rates of infection are high
even after ThPK. With the use of in vitro susceptibility testing, we managed few cases
with a novel combination of antibacterial drugs as the primary treatment for Pythium
insidiosum keratitis. After successful outcomes in those cases, we managed all our
cases (January 2017 to October 2018) on similar lines and evaluated their outcomes in
the present study.
题目：使用抗生素成功治疗腐霉菌性角膜炎（Pythium insidiosum Keratitis）
内容：管理腐霉菌性角膜炎有几个挑战，由于缺乏与其临床和微生物学特征有
关的信息以及有效的医学治疗方法。除少数轶事报道外，大多数研究建议将早
期治疗性穿透性角膜移植术（ThPK）作为主要治疗方法。然而，即使在 ThPK
之后，感染的复发率也很高。通过体外药敏试验，我们用新型抗菌药物组合处
理了少量病例作为治疗腐霉菌性角膜炎的主要方法。在这些尝试取得成功后，
我们以相似的方式处理了所有病例（2017 年 1 月至 2018 年 10 月），并在本研
究中评估了其结果。

8. Title: Retinal Artery Occlusion after Fat Injection Laryngoplasty

Contents: A 72-year-old man presented with significantly decreased vision in his left
eye for 10 days. He had received radiation therapy to the left submandibular gland
adenoid cystic carcinoma, and undergone autologous fat injection laryngoplasty for
vocal cord paralysis. Visual acuity was 20/50 in the left eye. Fundus showed multiple,
dispersed, refractile retinal arteriolar fat emboli with retinal whitening over the left the
paramacular region (Fig A). Fluorescein angiography revealed filling defects in
multiple branch retinal arteries consistent with the diagnosis of branch retinal artery
occlusions (Fig B and C). The patient had a normal lipid panel and no history of
atherosclerosis or carotid artery disease.
题目：脂肪注射喉成形术后视网膜动脉闭塞
内容：一名 72 岁的男性左眼视力明显下降 10 天。他既往接受了左下颌下腺腺
样囊性癌的放射治疗，并接受了自体脂肪注射喉成形术治疗声带麻痹。就诊时
左眼视力为 20/50。眼底显示了多个、散在、反光的视网膜小动脉脂肪栓子，在
黄斑旁的左侧，视网膜变白（图 A）。荧光素血管造影显示多分支视网膜动脉
充盈缺损，与视网膜分支动脉闭塞的诊断一致（图 B 和 C）。该患者血脂正常，
无动脉粥样硬化或颈动脉疾病史。
9. Title: Multimodal Imaging Findings in a Retinal Astrocytic Hamartoma
Contents: A 23-year-old man with a history of tuberous sclerosis presented with
multiple white globular elevated lesions bilaterally (Fig A). The most prominent of
these astrocytic hamartomas in his left eye was raised, cystic, and calcific (Fig A,
white line). En face OCT infrared scan (Fig B) highlights the clear cystic spaces.
Angiographic flow (Fig C) and en face OCT angiography (Fig D) demonstrates a
plexus of capillary vessels in the apex of the hamartoma.
题目：视网膜星形错构细胞瘤的多峰成像发现
内容：一名患有结节性硬化病史的 23 岁男子，双侧出现多发白色球状隆起病变
（图 A）。他的左眼中这些星形错构瘤最突出的特征是隆起，囊性和钙化（图
A，白线）。OCT 红外扫描（图 B）显示了清晰的囊性间隙。OCT 血管造影截
面（图 C）和正面（图 D）显示出错构瘤顶端的毛细血管丛。
10. Title: Nd:YAG Vitreolysis to Release Anteriorly Lodged Fluocinolone Acetonide
Insert
Contents: A 52-year-old woman with a history of persistent placoid maculopathy
presented with a new onset floater in her left eye 1 day after intravitreal injection of a
0.18-mg fluocinolone acetonide implant. Slit-lamp examination showed the implant
lodged behind the intraocular lens, which was mobile with eye movement and was
connected to a vitreous strand superiorly (Fig A and B, arrows). Initially, the patient
opted observation for spontaneous release of the implant outside the visual axis.
However, due to persistence of the floater blocking vision, Nd:YAG vitreolysis was
performed which resulted in immediate release of the implant and resolution of
symptoms (Fig C).
题 目： Nd ：YAG 玻 璃体 消融 术去 释放 出既 往 注 射后 未释 放 的 丙酮 氟诺 酮
（Fluocinolone Acetonide）
内 容 ： 一 名 52 岁 的 女 性 ， 患 有 持 续 性 的 斑 状 黄 斑 病 变 （ placoid
maculopathy），在左眼玻璃体内注射 0.18 mg 丙酮氟诺酮玻璃体内植入物后 1
天出现新的飞蚊症。裂隙灯检查显示植入物位于眼内晶状体后面，该漂浮物可
随眼球移动而移动，并与上方玻璃体相连（图 A 和 B，箭头）。最初，患者选
择继续观察，看植入物是否在视轴外自然释放。然而，由于漂浮物影响视力的
持续存在，进行了 Nd：YAG 玻璃体消融，导致植入物立即释放并缓解了症状
（图 C）。

11.Title: Trapped Perfluorocarbon Liquid after Descemet Membrane Endothelial

Keratoplasty
Contents: The cornea of a 62-year-old man with Fuchs endothelial dystrophy
decompensated following vitrectomy for macula-on retinal detachment and sequential
cataract surgery. Descemet membrane (DM) endothelial keratoplasty (DMEK) was
performed without complications. However, the inferior DM took weeks to attach
without the need for gas re-bubbling. Three months after DMEK, the patient
presented with best-corrected visual acuity of 20/32, moderate macular pucker, a clear
cornea and a normal central corneal thickness of 535 μm. Slit-lamp (Fig A) and OCT
(Fig B) showed small bubbles of perfluorocarbon liquid, which had remained
unnoticed in the eye after the retinal detachment surgery, trapped between the inferior
graft and the stroma.
题目：角膜内皮移植术（DMEK）后全氟化碳液体残留
内容：一名 62 岁的患有 Fuchs 内皮营养不良的男性，先因视网膜黄斑区脱离和
继发性白内障进行玻璃体切除术，后因术后角膜失代偿，进行角膜内皮移植术
（DMEK），无手术并发症。但是，下方的植片在不需要气体顶压的情况下需
要花费数周的时间才能附着。DMEK 术后三个月，患者最佳矫正视力 20/32，
黄斑中度褶皱，角膜透明和中央角膜厚度正常，为 535μm。裂隙灯（图 A）和
OCT（图 B）显示出小小的全氟化碳液体气泡，这些气泡在网脱术后未被发现，
并夹在移植物和基质之间。
12 ． Title: Systemic Corticosteroid Use after Central Serous Chorioretinopathy
Diagnosis
Contents: Retrospective commercial insurance claims-based analysis. Despite
evidence showing that steroids contribute to CSC development, many patients
continue to be prescribed systemic corticosteroids after CSC diagnosis. Our results
suggest a need for greater communication and collaboration among providers to
ensure that clinical practice reflects evidence-based recommendations.
题目：中心性浆液性脉络膜视网膜病变诊断后全身使用皮质类固醇
内容：基于商业保险索赔的回顾性分析显示：尽管有证据表明类固醇有助于
CSC 的发展，但许多患者在 CSC 诊断后仍继续使用全身性皮质类固醇。我们的
结果表明，医生之间需要加强沟通与合作，以确保临床实践反映出循证医学的
建议。

13.Title: Vision Impairment and Blindness Prevalence in the United States: Variability
of Vision Health Responses across Multiple National Surveys.
Contents: Prevalence rates for vision impairment(VI) increased significantly with
increasing age group, Based on weighted self-reported surveys, we estimated that 24.8
million persons (7.7%) had presenting VI or blindness. Prevalence rates of VI and
blindness obtained from national survey measures varied widely across surveys and
age groups. Additional research is needed to validate the ability of survey self-report
measures of VI and blindness to replicate results obtained through examination by an
eye health professional.
题目：美国视力障碍和失明患病率
内容：随着年龄的增长，VI 的患病率显着增加。根据加权的自我报告调查，我
们估计有 2480 万人（7.7％）出现 VI 或失明。在不同的调查和年龄组中，通过
国家调查方法获得的 VI 和失明患病率差异很大。需要进行更多的研究来验证对
VI 和失明者进行自我报告测量的能力，以确保眼保健专业人员的检查获得的结
果的重复性。