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Soft Tissue Tumor
Soft Tissue Tumor
described cases arose in the soft tissues near the knee joint
and a morphologic relationship to synovium was
postulated.
this name is a misnomer, as these tumors can present in
locations (chest wall, head and neck) that lack synovium
and their morphologic features are inconsistent with an
origin from synoviocytes.
Synovial sarcomas account for approximately 10% of all
soft tissue sarcomas and rank as the fourth most common
sarcoma.
Most occur in people in their 20s to 40s.
SYNOVIAL CELL SARCOMA
UPS are usually large, grey-white fleshy masses and can grow quite
large (10 to 20 cm) depending on the anatomic compartment.
Necrosis and hemorrhage are common.
They consist of sheets of large, anaplastic spindled to polygonal
cells with hyperchromatic irregular, sometimes bizarre nuclei
Mitotic figures, including atypical non-symmetric forms, are
abundant as is coagulative necrosis.
By definition, tumor cells lack differentiation along recognized
lineages.