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  • Inhibitori, Inhibitorii Cresc: Substrat Substraturile

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    Alina Ciugureanu
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    The document lists inhibitors, inducers, and substrates of several cytochrome P450 isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A group). Inhibitors increase the efficacy of other drugs metabolized by the same isozyme, while inducers decrease efficacy. The document provides examples of specific drugs that fall into each of these categories for several important cytochrome P450 isozymes involved in drug metabolism.

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    CYP450 - IIS

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    The document lists inhibitors, inducers, and substrates of several cytochrome P450 isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A group). Inhibitors increase the efficacy of other drugs metabolized by the same isozyme, while inducers decrease efficacy. The document provides examples of specific drugs that fall into each of these categories for several important cytochrome P450 isozymes involved in drug metabolism.

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    73 views4 pages

    Inhibitori, Inhibitorii Cresc: Substrat Substraturile

    Uploaded by

    Alina Ciugureanu
    The document lists inhibitors, inducers, and substrates of several cytochrome P450 isozymes (CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A group). Inhibitors increase the efficacy of other drugs metabolized by the same isozyme, while inducers decrease efficacy. The document provides examples of specific drugs that fall into each of these categories for several important cytochrome P450 isozymes involved in drug metabolism.

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    © All Rights Reserved
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    INHIBITORI, INDUCTORI si SUBSTRAT-uri ale CYTOCHROM P450 ISOZYMES

    Inhibitorii și Substraturile CRESC eficacitatea unui alt medicament metabolizat de acea izoenzima
    Inductorii SCAD eficacitatea

    CYP1A2
    Inhibitors Inducers Substrates
    Amiodarone Barbiturates Amitriptyline
    Cimetidine Carbamazepine Caffeine
    Ciproflxacin Omeprazole Lansoprazole Clomipramine
    Enoxacin Phenytoin Clozapine
    Erythromycin Rifampin Cyclobenzaprine Grepafloxacin
    Fluvoxamine Broccoli Imipramine
    Grepafloxacin Brussels Sprouts Mirtazapine
    Isoniazid Charcoal-Broiled Foods Olanzapine
    Mexiletine Cigarette Smoking Propranolol
    Norfloxacin R-Warfarin
    Tacrine Riluzole
    Zileuton Ropinirole
    Tacrine
    Theophylline
    Zileuton

    CYP2C9
    Inhibitors Inducers Substrates
    Amiodarone Barbiturates Carvedilol
    Cimetidine Carbamazepine Celecoxib
    Co-trimoxazole Rifampicin Diazepam
    Fluconazole Rifapentine Diclofenac
    Fluvoxamine Secobarbital Fluoxetine
    Isoniazid St. John's Wort Flurbiprofen
    Ketoconazole Fluvastatin
    Metronidazole Glibenclamide
    Zafirlukast Glimepiride
    Glipizide
    Ibuprofen
    Irbesartan
    Losartan
    Meloxicam
    Montelukast
    Naproxen
    Phenytoin
    Piroxicam
    Tolbutamide
    S-Warfarin
    Zafirlukast

    CYP2C19
    Inhibitors Inducers Substrates
    Chloramphenicol Carbamazepine Amitriptyline
    Cimetidine Rifampicin Citalopram
    Felbamate Clomipramine
    Fluoxetine Clopidogrel
    Fluvoxamine Diazepam
    Ketoconazole Imipramine
    Lansoprazole Lansoprazole
    Modafinil Omeprazole
    Omeprazole Pantoprazole
    Oxcarbazepine Phenytoin
    Pantoprazole Proguanil
    Propanolol
    R-Warfarin

    CYP2D6
    Inhibitors Inducers Substrates
    Amiodarone Rifampicin Amitriptyline
    Bupropion Carvedilol
    Celecoxib Chlorphenamine
    Chloroquine Chlorpromazine Clomipramine
    Cimetidine Clozapine
    Cimetidine Codeine
    Citalopram Desipramine Dextromethorphan
    Clomipramine Dihydrocodeine
    Clomipramine Diphenhydramine Donepezil
    Duloxetine Duloxetine
    Escitalopram Flecainide
    Fluoxetine Fluoxetine
    Fluphenazine Haloperidol
    Haloperidol Hydrocodone
    Levomepromazine Imipramine
    Paroxetine Loratadine
    Perphenazine Maprotiline Methamphetamine
    Propafenone Metoclopramide
    Propoxyphene Metoprolol
    Quinacrine Mexiletine
    Quinidine Mirtazpine
    Ritonavir Nortriptyline
    Sertaline Ondansetron
    Terbinafine Oxycodone
    Thioridazine Paroxetine
    Perphenazine
    Propafenone
    Propanolol
    Risperidone
    Ritonavir
    Tamoxifen
    Thoridazine
    Timolol
    Tolterodine
    Tramadol
    Trazodone
    Venlafaxine

    CYP3A GROUP
    Inhibitors Inducers Substrates
    Amiodarone Barbiturates Alfentanil
    Amprenavir Carbamazepine Dexamethasone Alprazolam
    Cimetidine Efavirenz Amiodarone
    Clarithromycin Ethosuximide Amlodipine
    Cyclosporine Griseofulvin Amprenavir
    Danazol Modafinil Aripiprazole
    Delavirdine Nafcillin Atorvastatin
    Diltiazem Nevirapine Bepridil
    Efavirenz Oxcarbazepine Buspirone
    Erythromycin Ethinylestradiol Phenobarbital Carbamazepine
    Fluconazole Phenytoin Cerivastatin
    Fluvoxamine Pioglitazone Ciclosporin
    Grapefruit Juice Primidone Citalopram
    Indinavir Rifabutin Clarithromycin
    Itraconazole Rifampicin Clomipramine
    Ketoconazole Rifampin Corticosteroids Hydrocortisone
    Nefazodone Rifapentine Cyclophosphamide
    Nelfinavir St. John's Wort Cyclosporine
    Quinine Dexamethasone
    Ritonavir Dapsone
    Saquinavir Delavirdine
    Synercid Diazepam
    Troleandomycin Diltiazem
    Verapamil Disopyramide
    Zafirlukast Domperidone
    Donepezil
    Doxorubicin
    Efavirenz
    Erythromycin
    Estradiol
    Etoposide
    Felodipine
    Fentanyl
    Finasteride
    Ifosfamide
    Imipramine
    Indinavir
    Itraconazole
    Ketoconazole
    Lansoprazole
    Lercanidipine
    Loratadine
    Losartan
    Lovastatin
    Methadone
    Midazolam
    Mirtazapine
    Montelukast
    Nefazodone
    Nelfinavir
    Nelfinavir
    Nicardipine
    Nifedipine
    Nimodipine
    Nisoldipine
    Paclitaxel
    Pimozide
    Progesterone
    Quetiapine
    Quinidine
    Quinine
    R-Warfarin
    Repaglinide
    Ritonavir
    Saquinavir
    Sertraline
    Sibutamine
    Sildenafil
    Simvastatin
    Sufentanil
    Tacrolimus
    Tamoxifen
    Testosterone
    Tolterodine
    Triazolam
    Troleandomycin
    Verapamil
    Vinblastine
    Vincristine
    Zaleplon
    Zileuton
    Zolpidem
    Zonisamide

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