http://trstriathlon.

com/are-antidepressants-performance-enhancing-drugs/

ABOUT THE AUTHOR: Julie Patterson is a professional triathlete with Maverick Multisport and a fifth year graduate
student at Virginia Commonwealth University in Richmond, VA. She is pursuing a Doctor of Pharmacy degree and a PhD
in Pharmacoeconomics and Outcomes Science. She lives in Richmond, VA with her husband, Tim, the all-star of non-
triathlete Sherpa spouses, and her dog, Soller, who is always the fastest dog at the dog park.

Are Antidepressants Performance-Enhancing Drugs?

WRITTEN BY JULIE PATTERSON SEPTEMBER 22, 2015

Doping scandals continue to rock endurance athletics. Discoveries, admissions, or allegations of EPO microdosing, abuse
of therapeutic use exemptions, and the use of other performance enhancing substances have dominated headlines in
cycling and distance running. Athletes and spectators use online forums to debate the ‘who’, ‘what’, ‘when’, and ‘how’
of doping in both professionals and amateurs.

As a professional triathlete and soon-to-be pharmacist reading these forums, I couldn’t help but notice the surprisingly
high number of forum posts debating the effects that antidepressants may or may not have on athletic performance.

In online forums, individuals with personal experience comment on their perceptions of how particular antidepressants
influenced their performance – positively or negatively. Most of these athletes are taking antidepressants for diagnosed
mental illnesses, particularly depression and anxiety. After all, research suggests that athletes are at least as likely as
nonathletes to experience depression.

A number of studies among NCAA athletes suggest that as many as 1 in 5 college athletes may be depressed. And while
the traditional stoicism of athletes to hide perceived weaknesses may prompt athletes to hide their depressive
symptoms, the media coverage of the 2014 suicide of University of Pennsylvania runner Madison Holleran highlighted
the unseen weight of depression in high-achieving athletes. If efforts to reduce the stigma associated with mental illness
are successful, more athletes may feel empowered to seek help for their illnesses, which may include starting an
antidepressant.

At the same time as depressed athletes seek appropriate treatment for their illness, non-depressed athletes may
question whether they could benefit from a dose or two of Prozac. The potential use of antidepressants in athletes who
are not depressed raises concerns about whether these drugs could offer an unfair performance advantage. The
underlying question here is this: Are Antidepressants Performance-Enhancing Drugs?

Improved athletic performance with SSRIs?

The most commonly prescribed antidepressants are in a class of medications known as Selective Serotonin Reuptake
Inhibitors (SSRI). This group includes drugs like Prozac (Fluoxetine), Zoloft (Sertraline), Lexapro (Escitalopram), Celexa
(Citalopram), and Paxil (Paroxetine), among others. These drugs improve symptoms of depression by altering the
amount and functioning of serotonin, a signaling molecule in the brain.

The idea that SSRIs improve athletic performance in athletes who are not depressed has its basis in studies linking
positive emotional states with enhanced athletic performance. This idea was popularized in the media following NFL
running back Ricky Williams’ breakout season. Prior to the season, he initiated SSRI treatment for an anxiety disorder. A
New York Times article commenting on his improved performance asked,

“What if a few Paxils in the Gatorade cooler could give a team that extra edge?”

A medical professor at the University of Colorado, San Diego asked in a commentary in the journal Psychiatry whether
athletes could unfairly improve their ability to compete in high-stress competitions by using antidepressants. An article
in Psychology Today stated, “SSRIs are boosting [athletes’] performance on the field.”
Despite these possible advantages, others theorize that SSRIs negatively impact performance because serotonin may.
Additionally, paroxetine, the first SSRI on the market, is often associated with weight gain, which may negatively impact
athletic performance. Newer SSRIs, however, are much less likely to cause weight gain.

Evidence: Antidepressant Use in Healthy Athletes

Do SSRIs Directly Improve Performance in Healthy Athletes?

The bottom line: No. Three studies in male cyclists – the results of which are highlighted in the table below – specifically
investigated questions surrounding the impacts of SSRIs on athletic performance.

# of doses of an SSRI Measure of Performance Change in athletic performance

2 doses Time trial ✘
1 dose Anaerobic power, fatigue index, ✘
V02 max
2 doses Time Trial ✘
Two weeks Anaerobic power, fatigue index, ✘
V02 max
These studies aren’t perfect: they are all small, included only male cyclists, and studied SSRI use for 2 weeks or less. As a
bit of context: the benefits of SSRIs for anxiety or depression are usually seen after much longer times – four to six
weeks. Nevertheless, all three studies come to the same conclusion: SSRI use does not impact athletic performance in
healthy athletes positively or negatively.

Do SSRIs Indirectly Improve Performance in Healthy Athletes by Improving Mood?

The bottom line: No, because SSRIs do not improve mood in individuals without depression or anxiety. The researchers
who analyzed sixty-five published articles on antidepressant use in individuals without a psychiatric condition sum up
what we know about SSRIs and mood in healthy people:

“In summary, no consistent evidence for enhancing effects of antidepressants could be found. There is little evidence so
far to support the popular opinion that antidepressants have a positive effect on the mood of healthy individuals after
repeated administration.”

SSRI use is thereby different from other medications that are abused by healthy athletes. Thyroid hormone and
testosterone, for example, directly increase hormone levels in the body regardless of whether the levels were low to
start with – hence the ability for a healthy athlete to use the drugs for an unfair advantage. Since SSRIs do not improve
mood in healthy athletes (or directly improve performance through some other mechanism), they offer little incentive
for abuse.

Drug SSRI Testosterone Thyroid Hormone

Positively impacts ✔ ✔ ✔
people with illness?
Positively impacts ✘ ✔ ✔
people without illness?

Do SSRIs impact perceptions of exhaustion?

The bottom line: The scientific community isn’t sure. Recall that serotonin may increase a person’s perceptions of
physical and mental fatigue. This is a distinct disadvantage to athletes who are training and competing at their physical
and mental limits. If SSRIs make athletes feel MORE fatigue, abuse of them by healthy athletes would HINDER success
rather than promote it! Several studies have looked at whether SSRIs impact healthy male cyclists’ perceptions of
exhaustion.

In these studies, cyclists are given either an SSRI or a placebo. They are then asked to ride to exhaustion, and researchers
measure how long they ride before stopping from exhaustion. Of the four studies conducted in this way, two reported
that athletes receiving one dose of an SSRI, and two reported that athletes receiving one dose of an SSRI did not feel
exhausted sooner. While the jury is still out on this question, we know that SSRIs do not reduce perceptions of
exhaustion (aka they do not provide a potentially performance-enhancing benefit by allowing athletes to train or
compete for longer before feeling exhausted).

Do Other Commonly Prescribed Antidepressants Impact Athletic Performance in Healthy Individuals?

The bottom line: Probably not. SSRIs are the most commonly prescribed antidepressants, but two additional types of
drugs are often prescribed for depression: the serotonin/norepinephrine reuptake inhibitors (SNRIs) and bupropion.

The SNRIs include Effexor (venlafaxine), Cymbalta (duloxetine), Pristiq (Desvenlafaxine), and others. Like SSRIs, these
drugs impact serotonin, but they also impact another brain signaling molecule – norepinephrine. Norepinephrine is
similar in structure and effect to epinephrine, a hormone that is on the World Anti-Doping Agency banned substances
list because it increases heart rate, glucose availability, and blood flow to muscles.

The SNRIs are also used to treat some chronic pain conditions. In theory, an improvement in pain tolerance could
improve performance. Again, we don’t see a lot of studies on the effects of SNRIs on athletic performance, but the
evidence we do have says that Effexor does not improve cycling time trial performance. And while the SNRIs may help
some chronic pain conditions, they haven’t been shown to help acute pain like the pain you’re going to feel during the
power test on your training plan next week. Therefore, based on the available evidence, SNRIs get the same assessment
as SSRIs: no impact on performance.

Bupropion (Wellbutrin, Zyban) is a different kind of antidepressant that, at the risk of oversimplifying, impacts both
norepinephrine, the hormone that’s similar to epinephrine, and dopamine, which is part of the brain’s reward system.
Bupropion is in the WADA 2015 Monitoring Program, which monitors substances “in order to detect patterns of misuse
in sport.” WADA lists bupropion as a stimulant along caffeine, nicotine, and phenylephrine (a decongestant that is less
stimulating – and less effective – than the pseudoephedrine found in Sudafed).

Bupropion does have some stimulating action. It is, after all, structurally similar to Ritalin, amphetamine (Adderall), and
cocaine! But does that mean that bupropion is enough of a stimulant to improve performance? The two studies on
bupropion in cycling time trial performance at moderate temperatures say “no”. In hotter temperatures, the link
between bupropion and performance is murkier. One study reported that bupropion improved performance; another
found that it did not. The inclusion of bupropion in the WADA Monitoring Program likely reflects both its stimulant
structure and the conflicting findings regarding performance improvement in hot conditions.

Conclusion

The bottom line: Despite popularized speculations of SSRIs as doping agents, SSRIs and SNRIs do not directly or indirectly
improve athletic performance in healthy athletes. To go one step further, they may or may not put a healthy athlete at a
disadvantage by making her feel exhausted more easily. If you are thinking about using an SSRI (Prozac, Zoloft, Lexapro,
etc.) or an SNRI (Effexor, Cymbalta, etc.) to boost your performance, think again. It’s not going to work. Do not pass go.
Do not collect $200.
What does the Evidence Say About Antidepressant Use in Athletes with
Depression and/or Anxiety?
Do Antidepressants Directly or Indirectly Improve Performance in Healthy Athletes?

The bottom line: maybe, maybe not, but it shouldn’t matter. Based on forum testimonials, an athlete’s performance may
improve if, as her depression improves, she regains her baseline motivation to train that was previously reduced by
depression. Remember here that an antidepressant will restore the athlete’s baseline personality and ability to function
but not will improve her motivation or drive beyond her normal, healthy state.

Conversely, she may feel that, as her anxiety improves, her “edge” softens, compromising her intensity in training. She
may feel less tired if fatigue was a symptom of her depression, but she may feel more tired if she experiences fatigue as
a side effect of the antidepressant. Similarly, she may gain or lose weight and sleep more or less after she starts an
antidepressant, depending on her symptoms of depression and the medication side effects. Physicians and athletic
patients with depression will need to work together to find a therapeutic regimen that improves symptoms while
minimizing side effects that may impact performance.

What’s Your Point?

SSRIs and SNRIs do not impact performance in healthy athletes. That is, if an athlete without depression or anxiety starts
on these antidepressants, performance will not improve. So, if an athlete WITH depression or anxiety starts on these
antidepressants and performance subsequently improves, that improvement can be attributed to the effective
treatment of the underlying illness. This is analogous to a legitimately hypothyroid patient experiencing a performance
boost with an appropriate dose of thyroid hormone (emphasis on legitimate and appropriate given recent allegations
about illegitimate hypothyroidism diagnoses and inappropriate dosing). I fervently hate doping and the way it degrades
our sport as much as you. But treating a legitimate medical illness with a drug that does not provide an unfair advantage
in healthy athletes should not be considered doping.

Most importantly, depressed athletes should not forgo treatment out of concerns that their performance will be
negatively impacted, that they will be gaining an “unfair” advantage, or that they will be perceived as “weak” amongst
their peers a result of their illness. I can personally testify to the burden of depression in elite athletes, as I recently
sought help for a relapse of major depression.

Many have commended the “strength” I displayed in making it to the start line at Timberman 70.3 after fracturing two
ribs the day before. Those who have not experienced or loved someone through depression may have a hard time
understanding that the strength required to race with fractured ribs paled in comparison to the strength required to
fight the burden of depression on a daily basis. I battled depression alone for months because I was worried that my
doctor would not believe that a successful graduate student and professional athlete could be depressed (he did) and
was afraid that an antidepressant would negatively impact my performance (it didn’t).

Those of us struggling with depression face enough barriers to getting the help we need. Let’s not let unfounded
concerns about antidepressants as doping agents get in the way of treating a legitimate and already unjustifiably
stigmatized illness.