BAB 1.

PRELIMINARY

Background

Effervescent tablets are tablets that produce gas when placed in water. Effervescent
tablets consist of a mixture of sodium bicarbonate with citric acid or tartaric acid which when
immersed in water will form foam or CO2 (carbon dioxide) gas. The gas that comes out is
carbon dioxide gas produced from the reaction between organic acids and carbonate
derivatives. This carbon dioxide gas helps accelerate the disintegration of the tablet and
increases the solubility of the active substance. In addition, this carbon dioxide gas also gives
a fresh taste as well as carbonated canned drinks. In addition to producing a clear solution,
these tablets also produce a pleasant taste due to the presence of carbonates which help
improve the taste of certain drugs.

Effervescent tablets require special working conditions and methods in their

manufacture because in these tablets there are two ingredients that cannot be combined,
namely sodium bicarbonate and organic acid because it will form carbon dioxide gas. The
reaction of these two ingredients will be accelerated in the presence of water, so the
effervescent tablet during the production process reaches the consumer's hands and should
not come into contact with water.

Formulation of the problem

1. What are the general components/formulations of effervescent tablets?

2. Advantages and disadvantages of effervescent tablets?

3. What is the method of making effervescent tablets and explain?

4. What are the properties and characteristics of effervescent tablets?

5. What is the evaluation of tablets, especially effervescent tablets?

6. What is the critical point of the effervescent preparation?

7. The requirements for the preparation of effervescent tablets are said to be good

8. How to pack and store effervescent tablets?

9. What should be considered in the manufacture of effervescent tablets?

10. Types of damage that may occur in tablet preparations

11. How to use effervescent tablets?

12. What are the possible reasons the effervescent tablet does not dissolve completely?

13. What is the solution for the scenario

Goal

Demonstrate mastery of theoretical and mathematical concepts in pharmaceutical

science related to safe, effective, stable and quality pharmaceutical formulations and
preparation technology based on scientific principles through identifying sources of
information, exploring, analyzing, compiling, and disseminating information related to drugs
and preparations other pharmacy. Able to work independently and responsible group

Scenario

BM is a QA staff. BM is currently handling customer complaints against effervescent

multivitamin products containing vitamins B1, B2, B6, B12, and vitamin C. The complaints
received are that the effervescent tablets do not dissolve completely.