DRUG CLASSIFICATION INDICATION ACTION AND CONTRAINDICATION ADVERSE EFFECT

PHARMACOKINETICS
Drug name: CNS Agent, Shortens REM and Action: Infabts <6mos of age, Body as a whole:
Diazepam Benzodiazepine, stage 4 sleep but Psychotherapeutic acute narrow-angle Troat and chest pain
Dose: Anticonvulsant, increases total sleep agent related to glaucoma; untreated GI:
Anxiolytic time. Antianxiety and chlordiazeperoxide; open-angle Xerostomia, nausea,
Anticonvulsant agent. reportedly superior in glaucoma; during or constipation, hepatic
antianxiety and within 14d of MAO dysfunction
anticonvulsant inhibitor therapy. Urogenital:
activity, with Incontinence, urinary
somewhat shorter retention,
duration of action. gynecomastia,
Like menstrual
chlordiazepoxide, it irregularities,
appears to act at both ovulation failure
limbic and subcortical CNS:
levels of CNS. Drowsiness, fatigue,
Pharmakonectics: ataxia, confusion,
Peak: paradoxic rage,
Duration: dizziness, vertigo,
Distribution: amnesia, vivid
Metabolic: dreams, headache,
Elimination: slurred speech,
Half life: tremor, EEg changes.
Other:
Pain, venous
thrombosis.
 DRUG CLASSIFICATION INDICATION ACTION AND CONTRAINDICATION ADVERSE EFFECT
PHARMACOKINETICS
Drug name: CNS Agent, Depresses abnormal Action: Patient with bledding Skin:
Valproic Acid Anticonvulsant, neuron discharges in Anticonvulsant disorders or liver Rash, photosensitivity,
(Divalproex Sodium) GABA Inhibitor the CNS, thus unrelated chemically dysfunction pr transient hairloss,
Dose: decreasing seizure to other drugs used disease, pregnancy, curliness and waviness
activity. to treat seizure lactation. of the hair.
disorders. GI:
Mechanism of action Nausea, vomiting,
unknown; may be indigestion,
related to increased hypersalivation,anorexia,
bioavailability of the with weight loss,
inhibitoruy increased appetitewith
neurotransmitter weight gain,abdominal
gamma-aminobutyric cramps, diarrhea,
acid (GABA) to brain constipation, liver
neurons. Inhibits failure, pancreatitis
secondary phase of Hematologic:
platelet aggregration. Prolonged bleeding time,
Pharmakonectics: leukopenia,
Peak: lymphocytosis,
1-4h valporic acid thrombosytopenia,
Distribution: hypofibrinogenemia,
Crosses placenta; bone marrow
distributed into breast depression, anemia.
milk CNS:
Metabolic: Breakthrough seizures,
Metabolized in liver
sedation, drowsiness,
Elimination:
dizziness,increased
Excreted in urine; small
amount excreted in alertness, hallucinations,
feces and expired air emotional upset,
Half life: aggression; deep coma,
5-20h death( with over dose)
Endocrine:
Irregular menses,
secondary amenorrhea
Metabolic:
Hyperammonemia,
hyperammonemic
encephalopathy in
patients with urea cycle
disorders.
Respiratory:
Pulmonary edema
(overdose)