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Herbert Boyer Insulin Synthetic "Human" Insulin U.S. Food and Drug Administration
Herbert Boyer Insulin Synthetic "Human" Insulin U.S. Food and Drug Administration
So yung genetically modified bacteria were the first organisms or yung pinakaunang organism
na ma modified in the laboratory, due to their simple genetics o madaling modified yung
chromosomes ng mga bacteria.
So dahil nga madaling imodified yung bacteria, naging important tool sya for the creation of
other GMOs
Dagdag pa na bacteria are cheap, or mura ng sya,
easy to grow, or madaling iculture
clonal, or narereplicate yung sarili
multiply quickly, yung nga madaling dumami
and are relatively easy to transform
• These organisms are now used for several purposes, and are particularly important in
producing large amounts of pure human proteins for use in medicine.
• Genetically modified bacteria are used to produce the protein insulin to treat diabetes.
The first example of this occurred in 1978 when Herbert Boyer, working at a University of
California laboratory, took a version of the human insulin gene and inserted into the
bacterium para makapag produce synthetic "human" insulin. Four years later, it was approved by
the U.S. Food and Drug Administration.
GM CROPS
So yung mga Genetically modified (GM) foods or crops are foods derived from organisms
whose genetic material (DNA) has been modified in a way that does not occur naturally
• In agriculture, genetically engineered crops are created to possess several desirable
traits, such as resistance to pests, herbicides, or harsh environmental conditions,
improved product shelf life, increased nutritional value, or production of valuable goods
such as drugs (pharming).
example ko po sa increased utritional value is yung ration sa military
alam nyo po ba yung ration? yan po yung binibigay sa mga soldier kapag may mission sila ko
kaya may combat, para mas madali nyo pong maintindihan, para siyang isang cracker or biscuit
pero ang katumbas ng isang cracker ay 1 meal, so 1 cracker equals 1 meal, parang yung
nutrients ng 1 meal, siniksik siya sa 1 cracker
MAMMALS
• Ralph L. Brinster and Richard Palmiter developed the techniques responsible for transgenic
mice, rats, rabbits, sheep, and pigs in the early 1980s.
Theoretically, daw all living beings can be genetically manipulated.
Animals. such as: sheep, goats, pigs, cows, rabbits, rats, mice, fish,
insects, parasites and even humans have previously been used in this
modification process. Mice, however, are the most popularly tested
animals in genetic modification studies.
Example ko dito si Dolly, o yung first mammal na naclone noong 1994,
however yubg pinaka common na ginegenetically manipulate is yung
mga mice kasi easy lng yung paghandle sa knila and then yung genome
ng mga mice is very similar satin kaya lagi silang ginagamit sa lab
• They established many of the first transgenic models of human disease, including the first
carcinoma caused by a transgene.
So mice mice din yung ginamit as the first transgenic models of human disease, and etong carcinoma
usually form solid tumors, and ito yung pinakacommon type na cancer. Examples din ng carcinomas
include prostate cancer, breast cancer and lung cancer.
So sa research na to, parang nakapagdevelop sila ng carcinoma sa skin ng mice, so etong study nati
makaktulong for better understanding ng canser and hopefully makatulong din na ma cure yung
ganitong sakit nato
• The process of genetically engineering animals is a slow, tedious, and expensive process.
However, new technologies are making genetic modifications easier and more precise.
GM fish are used for scientific research and as pets, and are being considered for use as food and as
aquatic pollution sensors.
so kahit Malaki yung advantages ng GMO satin, Malaki din yung risk nya kapag hindi natin siya nagamit
ng tama