Status of the Thyroid Ultrasound Examination results (October 15, 2021)

1. Preliminary Baseline Screening (First Round) (Tallied as of March 31, 2018)

【Conducted in FY2011-2013】
Primary examination (completed on April 30, 2015)
• Target population 367,637
• Participants 300,472 (81.7% participation rate)
• Completed test results 300,472 (100.0% completion rate)
• Test result categories
A (A1) : 154,605 (51.5%)
(A2): 143,573 (47.8%)
B: 2,293 ( 0.8%)
C: 1 ( 0.0%)

Confirmatory examination (as of March 31, 2018)

• Target population 2,293
• Participants 2,130 (92.9% participation rate)
• Completed test results 2,091 (98.2% completion rate)
547 participants underwent fine-needle aspiration cytology (FNAC)
Summary of FNAC results
• Suspicious or malignant 116
• Male : Female 39 : 77
• Average age 17.3±2.7 (8-22), 14.9±2.6 (6-18) at the accident time
Average tumor diameter 13.9±7.8 mm (5.1-45.0 mm)

Age and sex distribution of 116 suspicious or malignant cases

[Age as of March 11, 2011]

[Age on the date of confirmatory examination]

1
2. Full-Scale Screening (Second Round) (as of March 31, 2021)
【Conducted in FY2014-2015】
Primary examination
• Target population 381,237
• Participants 270,552 (71.0% participation rate)
• Completed test results 270,552 (100.0% completion rate)
• Test result categories
A (A1): 108,726 (40.2%)
(A2): 159,596 (59.0%)
B: 2,230 ( 0.8%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 2,230
• Participants 1,877 (84.2% participation rate)
• Completed test results 1,834 (97.7% completion rate)
207 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 71
• Male : Female 32 : 39
• Average age 16.9±3.2 (9-23), 12.6±3.2 (5-18) at the accident time
Average tumor diameter 11.1±5.6 mm (5.3-35.6 mm)

Age and sex distribution of 71 suspicious or malignant cases

[Age as of March 11, 2011]

[Age on the date of confirmatory examination]

2
3. Full-Scale Screening (Third Round) (as of March 31, 2021)
【Conducted in FY2016-2017】
Primary examination
• Target population 336,667
(Excluding those born in FY1992-1993, eligible for Age 25 Milestone Screening)
• Participants 217,922 (64.7% participation rate)
• Completed test results 217,922 (100.0% completion rate)
• Test result categories
A (A1): 76,431 (35.1%)
(A2): 139,989 (64.2%)
B: 1,502 ( 0.7%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 1,502
• Participants 1,104 (73.5% participation rate)
• Completed test results 1,068 (96.7% completion rate)
79 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 31
• Male : Female 13 : 18
• Average age 16.3±2.9 (12-23), 9.6±2.9 (5-16) at the accident time
Average tumor diameter 12.9±6.4 mm (5.6-33.0 mm)

Age and sex distribution of 31 suspicious or malignant cases

[Age as of March 11, 2011]

[Age on the date of confirmatory examination]

3
4. Full-Scale Screening (Fourth Round) (as of June 30, 2021)
【Conducted in FY2018-2019】
Primary examination
• Target population 294,237
(Excluding those born in FY1992-1995, eligible for Age 25 Milestone Screening)
• Participants 183,352 (62.3% participation rate)
• Completed test results 183,328 (100.0% completion rate)
• Test result categories
A (A1): 61,691 (33.6%)
(A2): 120,256 (65.6%)
B: 1,391 ( 0.8%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 1,391
• Participants 1,021 (73.4% participation rate)
• Completed test results 991 (97.1% completion rate)
87 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 36
• Male : Female 16 : 20
• Average age 16.6±3.0 (9-24), 8.1±2.9 (0-14) at the accident time
Average tumor diameter 13.3±6.4 mm (6.1-29.4 mm)

Age and sex distribution of 36 suspicious or malignant cases

[Age as of March 11, 2011] Note: Ages 15-18 not included in the fourth round.

Age “-1” includes those born between April 2, 2011 and April 1, 2012.
Those born between March 12, 2011 and April 1, 2011 are included in Age “0.”

[Age on the date of confirmatory examination]

4
5. Full-Scale Screening (Fifth Round) (as of June 30, 2021)
【Conducted in FY2020-2022】
Primary examination
• Target population 252,850
(Excluding those born in FY1992-1997, eligible for Age 25 Milestone Screening)
• Participants 32,404 (12.8% participation rate)
• Completed test results 24,882 (82.3% completion rate)
• Test result categories
A (A1): 7,844 (31.5%)
(A2): 16,747 (67.3%)
B: 291 ( 1.2%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 291
• Participants 175 (60..1% participation rate)
• Completed test results 144 (82.3% completion rate)
7 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 3
• Male : Female 0:3

6. Age 25 Milestone Screening (as of March 31, 2021)

【Conducted in FY2017 onward】
Primary examination
• Target population 87,694 (those born in FY1992-1995)
• Participants 7,621 (8.7% participation rate)
• Completed test results 7,260 (95.3% completion rate)
• Test result categories
A (A1): 3,102 (42.7%)
(A2): 3,799 (52.3%)
B: 359 ( 4.9%)
C: 0 ( 0.0%)

Confirmatory examination
• Target population 359
• Participants 239 (66.6% participation rate)
• Completed test results 227 (95.0% completion rate)
17 participants underwent FNAC
Summary of FNAC results
• Suspicious or malignant 9
• Male : Female 2:7
• Average age 25.2±0.8 (24-27), 17.0±0.7 (16-18) at the accident time
• Average tumor diameter 20.2±14.4 mm (9.4-49.9 mm)

5
The numbers of suspicious or malignant cases and surgical cases

Overall status from the first through fourth rounds as well as Age 25 Milestone Screening
Malignant or suspicious cases 266
Surgical cases 222
[1 benign nodule, 218 papillary thyroid cancer (PTC), 1 poorly differentiated thyroid
cancer (PDTC), 1 follicular thyroid cancer, and 1 other thyroid cancer]

First round (as of March 31, 2018) 【Conducted in FY2011-2013】

Total 116 (39 males : 77 females)
(102 surgically confirmed cases: 1 benign nodule, 100 PTC, 1 PDTC)

Second round (as of March 31, 2021) 【Conducted in FY2014-2015】

Total 71 (32 males : 39 females)
(56 surgically confirmed cases: 55 PTC, 1 other thyroid cancer)

Third round (as of March 31, 2021) 【Conducted in FY2016-2017】

• FY2016 municipalities 13 (7 males : 6 females)
(12 surgically confirmed cases: 12 PTC)
• FY2017 municipalities 18 (6 males : 12 females)
(17 surgically confirmed cases: 17 PTC)

Total 31 (13 males : 18 females)

(29 surgically confirmed cases: 29 PTC)

Fourth round (as of June 30, 2021) 【Conducted in FY2018-2019】

• FY2018 municipalities 20 (10 males : 10 females)
(15 surgically confirmed case: 15 PTC)
• FY2019 municipalities 16 (6 males : 10 females)
(14 surgically confirmed case: 14 PTC)

Total 36 (16 males : 20 females)

(29 surgically confirmed cases: 29 PTC)

Fifth round (as of June 30, 2021) 【Conducted in FY2020-2022】

• FY2020 municipalities 2 (0 male : 2 females)
(0 surgically confirmed case)
• FY2021 municipalities 0 (0 male : 1 female)
(1 surgically confirmed cases)

Total 3 (0 male : 3 females)

(1 surgically confirmed case: 1 PTC)

Age 25 Milestone Screening (as of March 31, 2021) 【Conducted in FY2017-】

Total 9 (2 males : 7 females)
(6 surgically confirmed cases: 5 PTC, 1 FTC)