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Article history: Childhood adversities are key aetiological factors in the onset and persistence of psychopathology. The
Received 24 February 2015 aims of this study were to identify childhood adversity profiles, and investigate the relationship between
Received in revised form 10 June 2015 the adversity classes and psychopathology in Northern Ireland. The study utilized data from the Northern
Accepted 24 July 2015
Ireland Study of Health and Stress, an epidemiological survey (N = 1986), which used the CIDI to examine
Available online 12 August 2015
mental health disorders and associated risk factors. Latent Class Analysis revealed 3 distinct typologies;
a low risk class (n = 1709; 86%), a poly-adversity class (n = 122; 6.1%), and an economic adversity class
Keywords:
(n = 155; 7.8%). Logistic Regression models revealed that individuals in the economic adversity class had
Childhood adversity
Psychopathology
a heightened risk of anxiety and substance disorders, with individuals in the poly-adversity class more
Epidemiology likely to have a range of mental health problems and suicidality. The findings indicate the importance of
Northern Ireland considering the impact of co-occurring childhood adversities when planning treatment, prevention, and
intervention programmes.
© 2015 Elsevier Ltd. All rights reserved.
http://dx.doi.org/10.1016/j.janxdis.2015.07.004
0887-6185/© 2015 Elsevier Ltd. All rights reserved.
M. McLafferty et al. / Journal of Anxiety Disorders 35 (2015) 42–48 43
maladjustment, impacted significantly on mental health in adult- the survey. Part 2 was then completed by a sub-sample of 1986 of
hood (Oladeji, Makanjuola, & Gureje, 2010). the original participants (950 males, 1036 females). All participants
Some surveys however have suggested that there may be cross- were 18 years of age or older and were English speakers, residing
national variations. The South Africa Stress and Health Study in NI. Non-English speakers, people residing in institutions, those
reported that Africans were more likely to have higher prevalence living in shared accommodation, including military barracks and
rates of CAs than Whites, with CAs impacting particularly on anx- prisons, and those with learning disabilities were excluded. The
iety disorders (Slopen et al., 2010). While American based studies investigation was carried out in accordance with the latest version
have suggested that CAs predict psychopathology in general (Green of the Declaration of Helsinki. Ethical approval was obtained from
et al., 2010; McLaughlin et al., 2011), a Japanese epidemiological the University of Ulster Research Ethics Committee and informed
study reported that certain disorders were associated with spe- consent was obtained from all participants after the study had been
cific adversities (Fujiwara & Kawalkami, 2011). Mood disorder, for fully explained.
example, was significantly related to parental mental health and
physical abuse; however, no specific childhood adversity was sig- 2.2. Diagnostic assessment
nificantly associated with the onset of anxiety disorders. While
Oladeji et al. (2010), in the NSMHW, found no significant relation- The WHO World Mental Health (WMH) Survey Initiative is a
ship with any specific adversity, they concluded that those who collaborative, epidemiological, systematic study which assesses
experienced three or more MFF adversities were 12 times more the incidence, prevalence, and correlates of mental health prob-
likely to develop anxiety disorders. lems using the WMH Composite International Diagnostic Interview
Traditionally, research assessing the link between CA and (CIDI) version 3.0 (Kessler & Üstün, 2004). This standardized
psychopathology has focused on one particular adversity. Contem- instrument retrospectively assesses mental health disorders in
porary knowledge now indicates that CAs often co-occur (Armour, accordance with ICD-10 and DSM-IV criteria and definitions, with
Elklit, & Christoffersen, 2014; Dunn et al., 2011; Rosenman & diagnostic hierarchy rules (Kessler et al., 2010). The current study
Rodgers, 2004). Accounting for co-occurrence rather than focus- examines any mood disorders (major depressive, dysthymic, bipo-
ing on the impact of single adversities is of paramount importance, lar I and II and sub-threshold bipolar disorders), any anxiety
given it is probable that different combinations of adversities may disorders (GAD, PTSD, panic, agoraphobia without panic disorder,
account for varying mental health outcomes. In addition, separat- social phobia, specific phobia, and separation anxiety disorders),
ing out the impact of a single adversity is problematic. Indeed, any substance disorders (drug and alcohol abuse, drug and alcohol
Shevlin and Elklit (2008) suggested that research should focus on dependence with abuse) and any suicide ideation and behaviour
individuals with similar adversity profiles. (gestures, plans, and attempts). In the NISHS all participants com-
Recent research has employed Latent Class Analysis (LCA) pleted part 1 of the fully structured interview, which includes
to identify the co-occurrence of CA’s; also referred to as poly- a screening section, demographic variables and core diagnostic
victimisation. Studies examining high risk individuals, such as assessment. Part 2, which is analysed in this study, contains a range
those in the juvenile justice system (Ford, Grasso, Hawke, & of diagnostic sections, along with risk factors such as childhood
Chapman, 2013) or those involved in mental health and social ser- adversities, consequences, and treatment, was completed by all
vices (Hazen, Connelly, Roesch, Hough, & Landsverk, 2009) reported participants who responded positively to core mental health disor-
that individuals with childhood maltreatment profiles have more der screening questions, plus 50% of those who were sub-threshold
psychological problems, with poly-victimised subgroups being par- cases and 25% of other participants who did not meet either crite-
ticularly vulnerable (Ford et al., 2013). A number of studies have rion; this allowed for the calculation of sampling weights.
utilized the latent profiles to examine associations with mental
health outcomes. Indeed, Dunn et al. (2011) found that different
2.3. Childhood adversities assessment
adversity profiles were associated with a range of specific mental
health problems.
CA questions are included in the childhood and PTSD sections of
The aims of the current study were (1) to examine the nature
the survey. This study utilized 12 CAs identified in previous WMH
and frequency of CAs reported in NI, (2) to assess poly-victimization
surveys (cf. Kessler et al., 2010). The retrospectively reported CAs,
across 12 independent childhood adversities and (3) to assess the
experienced before the age of 18 are presented in Table 1.
associations between childhood adversity classes and subsequent
mental health and suicidal outcomes in the NI population. Based
on previous literature, it was predicted that those categorized into 2.4. Demographic variables
groups endorsing multiple childhood adversities would have an
increased likelihood of reporting psychiatric morbidity and suicidal Demographic information, based on Part 2 of the survey is pre-
ideation and behaviour. sented in Table 3.
Table 2
Fit indices for Latent Class Models 1–5.
Note: AIC = Akaike information criterion, BIC = Bayesian information criterion, SSABIC = sample size adjusted BIC, LRT = Lo-Mendell-Rubin adjusted likelihood ratio test. The
log-likelihood for the 5 class model was not replicated. Optimal model is highlighted in bold.
M. McLafferty et al. / Journal of Anxiety Disorders 35 (2015) 42–48 45
behaviour and conflict related trauma variables across the three of a wide range of childhood adversities were more likely to exhibit
classes. suicidal ideation or behaviour (OR = 4.650, p < .001). Members of
this class also had the highest risk of suffering from an anxiety dis-
order (OR = 5.250, p < .001), any mood disorder (OR = 3.216, p < .001)
3.3. Logistic regression analyses or any substance disorder (OR = 4.759, p < .001). The experience of
conflict traumas related to the Troubles in Northern Ireland was sig-
3.3.1. Trauma profiles nificantly associated with a range of mental health problems and
Table 4 shows that when compared with the low risk class, suicidality, particularly anxiety disorders (OR = 3.122, p < .001).
individuals from typologies characterized by a greater degree of
adversity during childhood were more likely to have a range of
mental health problems. Odds ratios and 95% confidence intervals 3.3.2. Demographic associations
for all the variables of interest are presented in Table 4. In con- Males were significantly less likely to develop anxiety or
trast to the low risk class, the economic adversity class were more mood disorders but more likely to develop substance disorders
likely to suffer from an anxiety disorder (OR = 1.974, p < .01) or a (OR = 3.972, p < .001). Those who were previously married were
substance disorder (OR = 1.768, p < .05). When compared with the significantly more likely to develop a range of mental health prob-
low risk class, the poly-adversity class which endorsed high levels lems in comparison to people who were married/co-habiting, while
Table 3
Descriptive statistics for socio-demographics and prevalence of mental health, suicide ideation and behaviour and conflict related trauma variables across classes 1, 2, and 3.
Gender
Female 1164 (52.2%) 93 (45.9%) 93 (50.3%) 978 (52.9%)
Male 822 (47.8%) 73 (54.1%) 53 (49.7%) 696 (47.1%)
Age
Mean (SD) 45.4(17.6) 45.4(17.8) 40.8(13.1) 45.8(17.9)
Marital status
Married/Cohabitating 1174 (59.8%) 97 (56.8%) 77 (62.1%) 1000 (59.9%)
Previously married 342 (13.2%) 31 (15.3%) 31 (15.2%) 280 (12.9%)
Never Married 470 (27.0%) 38 (27.9%) 38 (22.7%) 394 (27.2%)
Years in education 12.5 (2.1) 12.4 (2.2) 12.6 (1.9) 12.5 (2.1)
Mean (SD)
Conflict trauma
No 1169 (61.0%) 80 (44.5%) 45 (27.8%) 1044 (64.9%)
Yes 817 (39.0%) 86 (55.5%) 101 (72.2%) 630 (35.1%)
Note: Class 1 = Economic adversity; Class 2 = Poly adversity; Class 3 = Baseline; OR = odds ratio; CI = confidence interval; Any Anxiety = any DSM Anxiety disorder; Any
Mood = any DSM Mood disorder; Any Substance = any DSM Substance disorder; any suicidal ideation and behaviour (gestures, plans, and attempts).
46 M. McLafferty et al. / Journal of Anxiety Disorders 35 (2015) 42–48
Table 4
Logistic regression analyses of socio-demographic, conflict trauma and latent class associations with mental health outcomes.
Predictor Any anxiety Any mood Any substance Any suicidal ideation/behaviour
OR OR OR OR
(95% CI) (95% CI) (95% CI) (95% CI)
Gender
Female 1.00 1.00 1.00 1.00
Male 0.389*** 0.502*** 3.972*** 0.721
(0.282–0.538) (0.382–0.661) (2.861–5.515) (0.492–1.056)
Marital status
Married/cohabit 1.00 1.00 1.00 1.00
Previously married 1.895** 1.997*** 2.278** 1.979**
(1.288–2.788) (1.419–2.811) (1.354–3.833) (1.284–3.051)
Never married 1.185 0.880 1.655* 1.018
(0.876–1.601) (0.637–1.218) (1.061–2.582) (0.658–1.574)
Note: Class 1 = Economic adversity; Class 2 = Poly-adversity; Class 3 = Baseline; OR = odds ratio; CI = confidence interval; Any Anxiety = Any DSM Anxiety disorder; Any
Mood = Any DSM Mood disorder; Any Substance = Any DSM Substance disorder; any suicidal ideation and behaviour (gestures, plans, and attempts).
*
Significant difference compared to base category <.05.
**
Significant difference compared to base category <.01.
***
Significant difference compared to base category <.001.
those who never married were more likely to have substance dis- Other studies have reported that CAs do not happen in isola-
orders (OR = 1.655, p < .05). Age was significantly associated with tion, with co-occurrence common (Armour et al., 2014). Using LCA
having a range of mental health problems, with older respon- to examine the co-occurrence of CAs and identify patterns of adver-
dents displaying a decreased likelihood of having anxiety disorders sity, three childhood adversity typologies were revealed in the NI
(OR = 0.989, p < .010), mood disorders (OR = 0.980, p < .001), sub- population. Class 3, the largest group representing 86% of the pop-
stance disorders (OR = 0.970, p < .0001) and suicidal ideation and ulation, had a low probability of experiencing CAs. Class 1, also had
behaviour (OR = 0.986, p < .01). a low probability of experiencing many adversities in childhood,
however, economic adversity was very high. This group also had
elevated levels of parental loss through death or divorce suggesting
4. Discussion that these are linked to economic adversity. Class 2, the poly-
adversity class, had a high probability of endorsing a wide range
The current study examined the prevalence of childhood adver- of childhood adversities, particularly those involving parental mal-
sities (CAs) in NI and used a person centred approach to uncover treatment and maladjustment.
patterns of adversity during childhood. In addition to a low The findings are consistent with previous studies which found
risk class, a class which had a high probability of experiencing that many CAs co-occur especially those termed maladaptive
economic adversity and a poly-adversity class were revealed. Sub- family functioning (Green et al., 2010; McLaughlin et al., 2010).
sequently, associations between these adversity typologies and However, the identification of a class endorsing high rates of eco-
socio-demographic factors and DSM mental health and suicidal nomic adversity indicates the magnitude of childhood economic
outcomes were assessed. In accordance with previous reports adversity in NI, which may be related to the respondents growing
(Hazen et al., 2009; Ford et al., 2013) individuals with childhood up during the Troubles (Gallagher, Hamber, & Joy, 2012). According
adversity profiles were found to have elevated levels of psy- to recent reports persistent child poverty remains high in compari-
chopathology. son with other areas in the UK (Kelly et al., 2012). This could suggest
Previous studies have reported high rates of CAs globally, how- that the Troubles and the deprivation that went with it are still
ever, this study found that the prevalence of CAs reported in NI were impacting indirectly on children in NI today.
generally lower than rates found in other countries (Kessler et al., With the low risk group acting as the reference group, LR mod-
2010), with the exception of economic adversity and parental men- els indicated that individuals who experienced adversities during
tal illness. While NI is classed as a high income country it has many childhood were more likely to have a range of mental health prob-
areas of deprivation which may partially account for these results. lems. A significant association was found between the class which
In comparison with other WMH surveys (Kessler et al., 2010), peo- endorsed high levels of economic adversity and anxiety and sub-
ple in NI were less likely to report CAs associated with parental stance disorders. This is in accordance with previous findings which
maladjustment and maltreatment. For example, reported levels of suggest that poverty increases sensitivity to stress, leaving a person
neglect, at 1.9%, were much lower than the rates found in other more susceptible to the development of mental health disorders
countries. It should be noted nonetheless that nearly a third of par- (McLaughlin et al., 2011). However, members of the poly-adversity
ticipants experienced adversities during childhood which is a great class displayed the greatest risk of suffering from an anxiety dis-
cause for concern. order and also had an elevated risk of a developing a DSM mood
M. McLafferty et al. / Journal of Anxiety Disorders 35 (2015) 42–48 47
disorder, substance disorder or suicidal ideation and behaviour. problems it did not significantly predict the persistence or sever-
This is consistent with previous studies that reported that child ity of disorders. Given the elevated rates reported in NI, further
abuse and family violence had the greatest impact on mental health research examining the long term impact of economic adversity
(DeVenter et al., 2013). on psychopathology may be particularly beneficial. Additionally,
Cross national variations have been found in other WMH sur- as it has been reported that the Troubles have had a very detrimen-
veys examining the impact of CAs on psychological wellbeing. Some tal impact on mental health it would be useful to explore patterns
studies reported that no specific adversity in childhood predicted of adversities in childhood in conjunction with experiences of the
anxiety disorders but that people who experienced a number of Troubles in the NI population.
CAs were at a heightened risk of developing the disorder (Oladeji
et al., 2010). This study corroborates these findings, with those 4.3. Conclusions
who experienced multiple adversities being five times more likely
to have an anxiety disorder. In accordance with other studies The prevalence and impact of economic adversity on mental
which reported significant associations between CAs and suicidal health was found to be particularly high in NI. Previous studies
behaviour (Bruffaerts et al., 2010), this study also found that those based in NI also reported that increased rates of psychopathology
who endured a range of adversities in childhood, the poly-adversity were associated with social deprivation (McConnell, Bebbington,
class, were over four and a half times more likely to display suicidal McClelland, Gillespie, & Houghton, 2002). Associations between
ideation and behaviour. In addition, members of this group were mental disorders and economic adversity need to be considered in
also more than four and a half times more likely to have a DSM terms of social and economic policies. Changes in the welfare bene-
substance disorder, and more than three times more likely to have fits for people with mental disorders will have a significant impact
a DSM mood disorder, corroborating the findings of other WMH on this population in NI and may impact further upon their men-
surveys (Fujiwara & Kawalkami, 2011; Slopen et al., 2010). tal health. Overall the study found that individuals from typologies
Additionally, significant associations were found between the characterized by a greater degree of adversity during childhood
demographic variables and psychopathology. In accordance with were more likely to report negative mental health and suicidal
previous studies, females were more likely to develop mood and outcomes, compared to typologies reporting fewer adversities. In
anxiety disorders and males were more likely to have substance dis- particular individuals who experienced a range of CAs were more
orders (Eaton et al., 2012). Younger respondents were much more than 5 times more likely to have an anxiety disorder. The findings
likely to have mental health problems and suicidal ideation and highlight the importance of considering the impact of co-occurring
behaviour. In addition, people who experienced conflict related CAs when planning treatment, prevention, and intervention pro-
traumas were significantly more likely to have negative mental grammes.
health outcomes as per previous findings (Priebe et al., 2010).
Role of funding source
4.1. Limitations
The survey was carried out in conjunction with the World
One of the main limitations of the study was that the sample may
Health Organization WMH Survey Initiative, which is supported by
not be fully representative of the population as a number of people
the National Institute of Mental Health (NIMH; R01 MH070884),
were omitted, including those with learning disabilities, immi-
the John D. and Catherine T. MacArthur Foundation, the Pfizer
grants, homeless people, and those in institutions. As these groups
Foundation, the US Public Health Service (R13-MH066849, R01-
often have higher levels of mental health problems, their omis-
MH069864, and R01 DA016558), the Fogarty International Center
sion may impact on the findings. However this omission is common
(FIRCA R03-TW006481), the Pan American Health Organization, Eli
practice in WMH surveys and this study followed the standardized
Lilly and Company, Ortho-McNeil Pharmaceutical, GlaxoSmithK-
format of the WMH-CIDI. Another limitation of the study could be
line, and Bristol-Myers Squibb. The NISHS was supported by a grant
the use of retrospective studies which cannot determine causality
from the Research and Development (R&D) Division in NI. The
and can be problematic due to recall bias. The rates of some child-
authors have support from the Commission for Victims and Sur-
hood adversities were lower than would be expected, particularly
vivors in Northern Ireland (CVSNI) for the submitted work; they
those related to abuse, which could suggest under reporting in the
have no relationships with the R&D Division NI or CVSNI that might
Northern Ireland population. This may be due to recall bias or a
have an interest in the submitted work. None of the funders had any
reluctance to share personal information. Additionally, in line with
role in the design, analysis, interpretation of results, or preparation
previous WMH papers, harsh physical punishment was excluded
of this paper.
from the current study (Kessler et al., 2010). Further research exam-
ining the impact of this adversity would be beneficial. In addition,
the findings in the current study may not be generalizable to other Conflict of interest
samples.
None.
4.2. Implications and future research
Contributors
While the study has some limitations, it nevertheless adds to
previous literature on CAs. The study provides valuable epidemi- Margaret McLafferty contributed to the development of the
ological information on a range of adversities and the detrimental theoretical rationale of the study, conducted literature searches,
impact they have on psychopathology in NI. It informs policy mak- carried out analyses, interpreted the results and wrote the first
ers and practice, highlighting the need to target children at risk of draft of this manuscript. Dr Cherie Armour supervised the study,
multiple adversities. The study emphasizes the importance of sta- contributed to the development of the theoretical rationale, con-
ble intra-family relationships and provides support for initiatives to ducted analyses and assisted in the editing of the paper. Dr Aine
improve parenting skills. In addition it shows that when planning McKenna contributed to the development of the theoretical ratio-
interventions it is important to consider co-occurrence of adversi- nale of the study, conducted analyses and assisted in the editing of
ties. While McLaughlin et al. (2011) found that economic adversity the final paper. Professor Siobhan O’Neil, Dr Sam Murphy and Pro-
in childhood predicted the onset of a range of mental health fessor Brendan Bunting coordinated the NISHS and were involved in
48 M. McLafferty et al. / Journal of Anxiety Disorders 35 (2015) 42–48
the design, supervision and editing of the final paper. All the afore- disorders in the national comorbidity survey replication 1: Associations with
mentioned authors contributed to the paper and approved the final first onset of DSM-IV disorders. Archives of General Psychiatry, 67(2), 113–123.
Hagenaars, J. A., & McCucheon, A. L. (Eds.). (2002). Applied latent class analysis.
manuscript. Cambridge: Cambridge University Press.
Hazen, A. L., Connelly, C. D., Roesch, S. C., Hough, R. L., & Landsverk, J. A. (2009).
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WP%20Analysis%20No.1%20-%20Kelly%20et%20al%20May2012 0.pdf
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