Name of Drug Classification Mechanism of Action Indication Contraindication Side Effects Nursing

Route and Responsibilities

Dosage
 Chloroquin  Antimalarial, Chloroquine inhibits the action Indications: - Hypersensitivit - Headaches - Assess
e Ambicide of heme polymerase in y to the drug - Seizures patient for
Brand Name: malarial trophozoites, Malaria, - Retinal and - Hypotensio allergies
Aralen Phosphate preventing the conversion of Intestinal visual field n regarding the
heme to Amebiasis changes - Blurred drug.
hemozoin. Plasmodium speci and - Porphyria Vision - Assess
es continue to accumulate Prophylaxis - Irreversible patient if
toxic heme, killing the of Malaria retinal he/she has
parasite. damage alcoholism,
Chloroquine passively Route: hepatic
diffuses through cell Oral(Tablet) disease and
membranes and into retinal
endosomes, lysosomes, and Dosages: disease.
Golgi vesicles; where it Suppression - Assess vital
becomes protonated, trapping — Adult signs
the chloroquine in the Dose: 500 especially;
organelle and raising the mg (= 300 blood
surrounding ph. The raised mg base) on pressure,
pH in endosomes, prevent exactly the heart rate
virus particles from utilizing same day of - Assess
their activity for fusion and each week. creatinine
entry into the cell. levels in
Chloroquine does not affect patients with
the level of ACE2 expression renal
on cell surfaces, but inhibits deficiency or
terminal glycosylation of failure.
ACE2, the receptor that
SARS-CoV and SARS-CoV-2
target for cell entry. ACE2 that
is not in the glycosylated state
may less efficiently interact
with the SARS-CoV-2 spike
 protein, further inhibiting viral
entry.

 Protease Lopinavir is an inhibitor of the - People with

 Lopinavir Inhibitor HIV-1 protease enzyme. Its allergy - Diarrhea
Brand Name: design is based on the Indications: - Cautiously use - Headache
Ritocom/Aluvia "peptidomimetic" principle, with: - Nausea - Assess the
wherein the molecule contains HIV 1.Pregnant - Vomiting patient’s
a hydroxy ethylene scaffold infections Women - Dizziness orientation.
which mimics the normal - Drowsiness - Make sure
peptide linkage (cleaved by 2.Hepatic patient is well
Route:
HIV protease) but which itself Impairment enough to
Oral
cannot be cleaved. By drive or to
preventing HIV-1 protease 3.Lactation perform tasks
activity, and thus the Dosages:
that require
proteolysis of the Gag HIV infection
4. Pancreatitis the patient to
polyprotein, lopinavir results in with other
be alert.
the production of immature, antiretroviral
- Monitor ECG,
non-infectious viral particles. s in
blood
treatment-
pressure,
naïve
heart rate and
patient:
pulse rate.
800mg
Lopinavir - Notify
once daily or physician for
divided any
evenly bid. Irregularities

Interleukin 6 (IL-6) is a pro-

inflammatory cytokine
produced by cells including T-
cells, B-cells, lymphocytes,
monocytes, fibroblasts. IL-6
rapidly induces C-reactive
protein, serum amyloid A,
 fibrinogen, haptoglobin, and
α-1-antichymotrypsin while
inhibiting production of
 Interleukin-6 fibronectin, albumin, and - Hypersensitivit
 Tocilizuma (IL-6) transferrin. IL-6 also induces y to - Increased
b blockers. It antibody production, induces Tocilizumab. blood
Brand Name: works by cytotoxic T-cell differentiation, Reactions: pressure
Actemra blocking IL-6, and inhibits regulatory T-cell Anaphylaxis levels
a substance differentiation. Tocilizumab Indications: - Swelling - Monitor
made by the binds soluble and membrane - Headache neutrophil
body that bound IL-6 receptors, - Dizziness and platelet
Moderate to
causes preventing IL-6 mediated - Sinus pain counts before
Severe
swelling inflammation. - Sore throat and after
Rheumatoi
(inflammation treatment
d Arthritis
). - Assess
Route: patient for
SC gastrointestin
Injection al ulcers
- Monitor signs
and
Dosages:
symptoms of
CNS
4 mg/kg IV
demyelinating
q4Weeks
disorders.
initially; may
increase to 8
mg/kg
q4Weeks
based on
clinical
response