THE CYTOTOXIC EFFECT OF SEAWEEDS ON

MICHIGAN CANCER FOUNDATION – 7

BREAST CANCER CELL LINE

A Research Proposal
Presented to the Faculty of the
Matias H. Aznar Memorial
College of Medicine
Cebu City

In Partial Fulfillment of
The Requirements for
Pharmacology and Toxicology

by:
Abella, Ian Norvic R.
Bascug, Alex William V.
Cagulada, Shaira Lyn P.
Escalada, Szczecenn Edecca A.
Lontoc, Irish C.
Pana, Bryan Jay Carlo A.
Signo, Aileen Ruth D.
Tiu, William Jr. C.
Yap, Rayford Jr. L.
[Group 1, Med 2B]

November 2017
 APPROVAL SHHET

This research paper entitled, “THE CYTOTOXIC EFFECT OF SEAWEEDS ON

MICHIGAN CANCER FOUNDATION – 7 BREAST CANER CELL LINE” was
prepared and submitted by IAN NORVIC R. ABELLA, ALEX WILLIAM V.
BASCUG, SHAIRA LYN P. CAGULADA, SZCZECENN EDECCA A.
ESCALADA, IRISH C. LONTOC, BRYAN JAY CARLO A. PANA, AILEEN RUTH
D. SIGNO, WILLIAM C. TIU JR., and, RAYFORD L. YAP JR., in partial fulfillment
of the requirements for the degree DOCTOR OF MEDICINE, to the Proposal
Hearing Committee for Proposal Hearing.

JOSE M. OCLARIT, PhD

Research Director

PROPOSAL HEARING COMMITTEE

Approved by the Proposal Hearing Committee with a grade of ___________ on

November 14, 2017.

JOSE M. OCLARIT, PhD

Chairman

DONNY JAY YU, MD, FPCP, DPCCP ARLENE M. DIAZ, MD, FPSECP, EdD
Member Member

VIRGETTE GAY MOLLANEDA – DIOMAMPO, MD, FPCC, FPCP

Member

Accepted and approved in partial fulfillment of the requirements for the degree of
DOCTOR OF MEDICINE.

MA. SOCORRO G. MANALOTO, MD, FPOGS

Dean
Matias H. Aznar Memorial College of Medicine
 iii

ACKNOWLEDGEMENT

There are a number of people without whom this research paper might not have

been written, and to whom the researchers are greatly indebted. The researchers

would like to thank the following:

First and foremost the Almighty God for his grace and blessings for without

which, this research would not have taken place.

To their parents and families, for the emotional and financial support much

needed in the making of this proposal, for the unquestioning understanding for the

late nights spent for the paper and for the patience in response to our needs in

relation to the proposal completion.

To the MHAM Research Director, Dr. Jose Oclarit for his insight, suggestions and

guidance that benefited the researchers in the completion of this study.

To the members of the panels of oral examiners during the proposal and final

defenses, their suggestions and recommendations have been sincerely invaluable.

ABELLA, BASCUG, CAGULADA, ESCALDA, LONTOC, PANA, SIGNO, TIU & YAP
 TABLE OF CONTENTS

Page

Title Page . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .i

Approval Sheet . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ii

Acknowledgement . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iii

Table of Contents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .iv

List of Tables . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vi

List of Figures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii

Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .viii

Chapter

I. INTRODUCTION

Rationale . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1

Conceptual Framework . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3

Objectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3

Statement of Hypothesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4

Scope and Delimitation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4

Significance of the Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5

II. REVIEW OF RELATED LITERATURE

Review of Related Literature . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .6

Definition of Terms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

III. METHODOLOGY

Study Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .11

Data Gathering Procedures . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

 v

Statistical Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .13

IV. RESULTS AND DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

V. SUMMARY OF FINDINGS, CONCLUSION, AND

RECOMMENDATIONS

REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

APPENDICES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

CURRICULUM VITAE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
 LIST OF TABLES

Table Page
 vii

LIST OF FIGURES

Figure Page

1. Conceptual Framework 3