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  • List of Reference Measurement Methods/procedures For Metabolites and Substrates

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    Luis carlos Quinto cuzcano
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    The document lists reference measurement methods for various metabolites and substrates, including bilirubin, creatinine, free glycerol, and glucose. Reference methods are listed along with the applicable sample matrices, measurement principles or techniques used, and relevant references. Reference methods include spectrophotometry, isotope dilution gas chromatography/mass spectrometry, isotope dilution liquid chromatography/mass spectrometry, and enzymatic methods. The document provides a high-level overview of established reference measurement procedures for important clinical analytes.

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    The document lists reference measurement methods for various metabolites and substrates, including bilirubin, creatinine, free glycerol, and glucose. Reference methods are listed along with the applicable sample matrices, measurement principles or techniques used, and relevant references. Reference methods include spectrophotometry, isotope dilution gas chromatography/mass spectrometry, isotope dilution liquid chromatography/mass spectrometry, and enzymatic methods. The document provides a high-level overview of established reference measurement procedures for important clinical analytes.

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    © All Rights Reserved
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    44 views6 pages

    List of Reference Measurement Methods/procedures For Metabolites and Substrates

    Uploaded by

    Luis carlos Quinto cuzcano
    The document lists reference measurement methods for various metabolites and substrates, including bilirubin, creatinine, free glycerol, and glucose. Reference methods are listed along with the applicable sample matrices, measurement principles or techniques used, and relevant references. Reference methods include spectrophotometry, isotope dilution gas chromatography/mass spectrometry, isotope dilution liquid chromatography/mass spectrometry, and enzymatic methods. The document provides a high-level overview of established reference measurement procedures for important clinical analytes.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    JCTLM database : Laboratory medicine and in vitro diagnostics

    List of reference measurement methods/procedures for Metabolites and substrates

    PDF description of measurement method/procedure contains limited information on methods/procedures. More complete information can be retrieved from the keyword search
    results for the reference measurement methods/procedures.

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    lyophilized, fresh or frozen
    blood serum, blood plasma,
    bilirubin AACC reference method for bilirubin Absorption spectrometry Clin. Chem., 1985, 31, 1779-1789
    or calibration solution; and,
    other biological material
    Doumas reference lyophillized, fresh or Clin. Chem., 1985, 31, 1779-1789
    bilirubin Spectrophotometry
    method for total bilirubin frozen human serum Clin. Chem., 1983, 29, 297-301
    Siekmann et al., J. Clin. Chem.
    DGKC reference method lyophilized, fresh, or frozen
    creatinine ID/GC/MS Clin. Biochem., 1985, 23, 137-144
    for serum creatinine human serum or plasma
    Metrologia, 2003, 40, Tech. Suppl., 08005
    Siekmann et al., J. Clin. Chem.
    DGKC reference method lyophilized, fresh, or
    creatinine ID/GC/MS Clin. Biochem., 1985, 23, 137-144
    for urine creatinine frozen human urine
    Metrologia, 2003, 40, Tech. Suppl., 08005
    NIST reference method lyophilized, fresh, or Anal. Chem., 1986, 58, 1681-1685
    creatinine ID/GC/MS
    for serum creatinine frozen human serum Metrologia, 2003, 40, Tech. Suppl., 08005
    Clin. Chem., 1993, 39,1001-1006
    Clin. Chem., 1993, 39, 993-1000
    University of Ghent reference lyophilized, fresh, or
    creatinine ID/GC/MS Eur. J. Clin. Chem. Clin. Biochem., 1996, 34, 853-860
    measurement procedure for creatinine frozen human serum
    Clin. Chem., 1995, 41 , 995-1003
    EUROMET 563
    NIM reference method lyophilized, fresh, or
    creatinine ID/LC/MS, ID/LC/MS/MS Anal. Let., 2008, 41, 2912-2922
    for serum creatinine frozen human serum

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 1/6
    JCTLM database : Laboratory medicine and in vitro diagnostics

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    NIST ID-LC/MS method fresh, frozen, and
    creatinine ID-LC/MS Clin. Chem., 2007, 53:9, 1694-1699
    for serum creatinine lyophilized human serum
    J.Chromatogr. B, 2003, 794, 125-136
    LGC reference method for
    creatinine lyophilized or frozen serum Isotope dilution LCMS Metrologia, 2003, 40, Tech. Suppl., 08003
    creatinine in serum by ID/LC/MS
    IMEP-17
    Stosch et al., Anal. Chem., 2005, 77, 7386-7392
    Isotope dilution surface
    ID/SERS reference measurement lyophilized, fresh, or Zakel et. al., Analyst, 2011, 136, 3956-3961
    creatinine enhanced Raman
    method for serum creatinine frozen human serum IFCC-RELA 2010
    scattering (ID/SERS)
    EURAMET TC-MC Project 1176
    free glycerol CDC method for free glycerol in serum fresh, frozen, lyophilized serum ID/GC/MS J. Chromatogr., 1992, 578, 1-7
    Developing a reference measurement procedure
    HSA ID/GC/MS reference
    for free glycerol in human serum by two-step gas
    free glycerol measurement procedure for human serum ID/GC/MS
    chromatography-isotope dilution mass spectrometry, Liu
    free glycerol in human serum
    Q. et al., Clinical Biochemistry, 2015, 48(13-14), 897-903
    glucose JSCC reference method blood serum Enzymatic
    lyophilized, fresh or frozen
    blood serum, blood plasma,
    glucose DGKL reference method for glucose whole blood, urine, or ID/GC/MS Biomedical Mass Spectrometry, 1982, 9, 395-405
    calibration solution; and,
    other biological material
    NIST reference method lyophilized, fresh, or Biomed. Mass. Spectrom., 1982, 9, 395-405
    glucose ID/GC/MS
    for serum glucose frozen human serum Metrologia, 2003, 40, Tech. Suppl., 08003
    Clin. Chem., 1993, 39, 1001-1006
    University of Ghent reference lyophilized, fresh, or Clin. Chem., 1993, 39, 993-1000
    glucose ID/GC/MS
    method for glucose frozen human serum Eur. J. Clin. Chem. Clin. Biochem., 1996, 34, 853-860
    EUROMET 563
    HSA ID/LC/MS/MS reference High accuracy analysis of glucose in human serum by isotope
    glucose measurement procedure human serum ID/LC/MS/MS dilution liquid chromatography-tandem mass spectrometry,
    for glucose in human serum Chen Y. et al., Clinica Chimica Acta, 2012, 413(7-8), 808-813

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 2/6
    JCTLM database : Laboratory medicine and in vitro diagnostics

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    Determination of serum glucose by isotope dilution liquid
    chromatography-tandem mass spectrometry: a candidate
    Isotope Dilution Mass reference measurement procedure, Zhang T, et al.,
    NCCL ID LC-MS/MS reference human serum; fresh, Spectrometry (IDMS), Analytical Bioanalytical Chemistry, 2016, 408(26), 7403-7411
    glucose
    measurement procedure for glucose frozen or lyophilized Liquid Chromatography Agreement between the ID LC-MS/MS and the
    Mass Spectrometry (LCMS) ID GC-MS reference measurement procedures
    for Glucose, Electronic Supplement Material of
    Analytical Bioanalytical Chemistry 2016 publication.
    CDC Hexokinase reference Neese JW et al., HEW Pub No. (CDC)
    glucose human serum Spectrophotometry
    method for glucose 77-8330, HEW, USPHS, CDC, 1976
    Ultracentrifugation removes
    VLDL, d < 1.006, preventing
    interference (TG) with the
    CDC reference method for In: Handbook of Lipoprotein Testing, 2nd Edition.
    HDL cholesterol fresh or frozen serum heparin/Mn2+ precipitation
    HDL cholesterol in serum Washington DC: AACC Press 2001: 227-230.
    step for removal of
    non-HDL. HDL cholesterol
    is spectrophotometric.
    NIST GC/MS reference method lyophilized, fresh, or Anal. Chem., 2003, 75, 775-784
    homocysteine ID/GC/MS
    for serum homocysteine frozen human serum Anal. Chem., 2003, 75, 4631-4638
    NIST LC/MS reference method lyophilized, fresh, or Anal. Chem., 2003, 75, 4631-4638
    homocysteine ID/LC/MS/MS
    for serum homocysteine frozen human serum See reference cited for comparability assessment study
    NIST LC/MS/MS reference lyophilized, fresh, or Anal. Chem., 2003, 75, 4631-4638
    homocysteine ID/LC/MS/MS
    method for serum homocysteine frozen human serum See reference cited for comparability assessment study
    25-hydroxyvitamin D2 NIST methods for 25-hydroxyvitamin D serum, plasma ID-LC-MS/MS Anal. Chem., 2010, 82, 1942
    25-hydroxyvitamin D3 NIST methods for 25-hydroxyvitamin D serum, plasma ID-LC-MS/MS Anal. Chem., 2010, 82, 1942
    Ultracentrifugation removes
    VLDL, d < 1.006, preventing
    CDC beta-quantification reference
    interference (TG) with the
    method for LDL cholesterol In: Handbook of Lipoprotein Testing, 2nd Edition.
    LDL cholesterol fresh, or frozen serum heparin/Mn2+ precipitation
    in serum, (extension of CDC Washington DC: AACC Press 2001: 227-230.
    step for removal of non-HDL.
    HDL cholesterol method)
    HDLC quantitation is
    spectrophotometric.

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 3/6
    JCTLM database : Laboratory medicine and in vitro diagnostics

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    NIST LC/MS reference lyophilized, fresh, or
    5-methyltetrahydrofolic acid ID/LC/MS Anal. Biochem., 2003, 313, 117-127
    method for serum folate frozen human serum
    Jones oxidation and high performance liquid chromatographic
    analysis of cholesterol in biological samples, Chen
    NCCL HPLC Reference lyophilized, fresh, or W et al., J. Chromatogr. B, 2007, 858, 239-246.
    total cholesterol HPLC
    procedure for serum Cholesterol frozen human serum IFCC External Quality assessment scheme for
    Reference Laboratories in Laboratory Medicine
    (RELA); Results for year 2003; Labcode: 18
    Edwards SH, et al Clin. Chem., 2011, 57, 614-622
    CDC ID/GC/MS reference lyophilized, fresh, or
    total cholesterol ID/GC/MS IFCC-RELA (External Quality assessment scheme
    measurement procedure for cholesterol frozen human serum
    for Reference Laboratories in Laboratory Medicine)
    DGKC reference method lyophilized, fresh, or frozen Siekmann et al., Z. anal. Chem., 1976, 279, 145-146
    total cholesterol ID/GC/MS
    for serum cholesterol human serum or plasma Metrologia, 2004, 39, Tech. Suppl., 08001
    Anal. Chem., 1989, 61, 1718-1723
    NIST reference method lyophilized, fresh, or
    total cholesterol ID/GC/MS Metrologia, 2004, 39, Tech. Suppl., 08001
    for serum cholesterol frozen human serum
    Clin. Chem., 1990, 36, 370-375
    Clin. Chem., 1993, 39, 1001-1006
    Clin. Chem., 1993, 39, 993-1000
    University of Ghent reference lyophilized, fresh, or
    total cholesterol ID/GC/MS Eur. J. Clin. Chem. Clin. Biochem., 1996, 34, 853-860
    method for cholesterol frozen human serum
    Clin. Chem., 1996, 42, 531-535
    EUROMET 563
    Serum cholesterol measured by isotope dilution liquid
    chromatography tandem mass spectrometry, Chen W
    NCCL ID-LC/MS/MS Reference lyophilized, fresh, or et al., Clin. Chem. Lab. Med., 2011, 49(4), 669-676.
    total cholesterol ID-LC/MS/MS
    procedure for serum Cholesterol frozen human serum IFCC External Quality assessment scheme for Reference
    Laboratories in Laboratory Medicine (RELA); Results
    for year 2006, 2007, 2009, and 2012; Labcode: 18
    Rapid Commun. Mass Spectrom., 2002, 16, 848-853
    Isotope dilution of cholesterol
    total cholesterol lyophilized or frozen serum Isotope dilution LCMS Metrologia, 2004, 39, Tech. Suppl., 08001
    by LCMS, Org-005
    IMEP-17
    CDC Abell-Kendall lyophilized, fresh, or Cooper GR et al., Clin. Chem., 1986, 32, 921-929
    total cholesterol Spectrophotometry
    method for cholesterol frozen human serum Clin. Chem., 1990, 36, 370-375

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 4/6
    JCTLM database : Laboratory medicine and in vitro diagnostics

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    Siekmann et al., Z.anal. Chem., 1986, 324, 280-281
    DGKC reference method lyophilized, fresh, or frozen Benchmarked with PTB reference method
    total glycerides ID/GC/MS
    for serum total glycerides human serum or plasma for serum total glycerol; for information,
    contact lothar.siekmann@ukb.uni-bonn.de
    NIST reference method lyophilized, fresh, or
    total glycerides ID/GC/MS Clin. Chem., 1995, 41, 397-404
    for serum total glycerides frozen human serum
    University of Ghent
    lyophilized, fresh, or
    total glycerides reference measurement ID/GC/MS Eur. J. Clin. Chem. Clin. Biochem., 1996, 34, 853-860
    frozen human serum
    procedure for total glycerides
    Reference Measurement Procedure for Total
    CDC ID/GC/MS reference measurement lyophilized, fresh, or
    total triglycerides ID-GC/MS Glycerides by Isotope Dilution GC-MS, Edwards
    procedure for total triglycerides frozen human serum
    S. et al., Clin. Chem., 2012, 58(4), 768-776
    NIST reference method lyophilized, fresh, or
    triglycerides ID/GC/MS Clin. Chem., 1995, 41, 397-404
    for serum triglycerides frozen human serum
    JSCC Recommended lyophilized, fresh,
    triglycerides Spectrophotometry
    Method for triglycerides frozen plasma or serum
    lyophilized, fresh, or frozen
    urea DGKC reference method for urea ID/GC/MS Kessler et al., Clin. Chem., 1999, 45, 1523-1529
    human serum or plasma
    lyophilized, fresh, or
    urea DGKC reference method for urea ID/GC/MS Kessler et al., Clin. Chem., 1999, 45, 1523-1529
    frozen human urine
    lyophilized, fresh, or
    urea NIST reference method for serum urea ID/GC/MS Anal. Chem., 1984, 56, 713-719
    frozen human serum
    Candidate reference measurement procedure
    for determination of urea in serum by liquid
    Isotope dilution liquid
    GPHCM reference measurement human serum; fresh, chromatography-tandem mass spectrometry, Han L. et al,
    urea chromatography
    method for serum urea frozen or lyophilized Journal of Pharmaceutical and
    mass spectrometry
    Biomedical Analysis , 2019, 162, 124-129
    C16RMP12R Inter-laboratory Comparison Report

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 5/6
    JCTLM database : Laboratory medicine and in vitro diagnostics

    Reference measurement Measurement


    Analyte Applicable matrice(s) Reference(s)
    method/procedure principle/technique
    Liquid chromatography isotope dilution tandem mass
    spectrometry method for the measurement of urea in
    HSA ID/LC/MS/MS reference Liquid chromatography-isotope human serum and assignment of reference values to
    urea measurement procedure human serum dilution tandem external quality assessment samples, Yong S. et al,
    for urea in human serum mass spectrometry International Journal of Mass Spectrometry. 2017, 414, 87-93
    CCQM-K109, High polarity analytes in biological matrix:
    determination of urea and uric acid in human serum
    urea CDC reference method for urea human serum Spectrophotometry Sampson EJ et al., Clin. Chem., 1980, 26, 816-826
    Siekmann et al., J. Clin. Chem.
    Clin. Biochem., 1985, 23, 129-135
    lyophilized, fresh, or frozen
    uric acid DGKC reference method for uric acid ID/GC/MS Benchmarked with PTB reference method for
    human serum or plasma
    uric acid in serum or plasma; for information,
    contact lothar.siekmann@ukb.uni-bonn.de
    Siekmann et al., J. Clin. Chem.
    Clin. Biochem., 1985, 23, 129-135
    lyophilized, fresh, or
    uric acid DGKC reference method for uric acid ID/GC/MS Benchmarked with PTB reference method
    frozen human urine
    for uric acid in urine; for information,
    contact lothar.siekmann@ukb.uni-bonn.de
    NIST reference method lyophilized, fresh, or
    uric acid ID/GC/MS Anal. Chem., 1990, 62, 2173-2177
    for serum uric acid frozen human serum
    Clin. Chem., 1993, 39, 1001-1006
    University of Ghent reference lyophilized, fresh, or
    uric acid ID/GC/MS Clin. Chem., 1993, 39, 993-1000
    method for serum uric acid frozen human serum
    Eur. J. Clin. Chem. Clin. Biochem., 1996, 34, 853-60
    NIM reference method lyophilized, fresh, or
    uric acid ID/LC/MS, ID/LC/MS/MS J. Chromatogr. B, 2007, 857, 287-295
    for serum uric acid frozen human serum

    Database of higher-order reference materials, measurement methods/procedures and services. 04 February 2021 6/6

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