IRAC Mode of Action Classification (July 2009)

of insecticides and insecticides registered in India

Main group and primary Chemical subgroup or Active ingredient /insecticide
site of action exemplifying active registered in India
ingredients
1. Bendiocarb, Benfuracarb,
Acetylcholinesterase 1A Carbaryl, Carbofuran,
(AChE) inhibitors Carbamates Carbosulfan,
Nerve action Fenobucarb, Methomyl,
Propoxur, Thiodicarb,
Dazomate
1B Acephate, Anilophos,
Organophosphates Chlorfenvinphos,
Chlorpyrifos,
Chlorpyrifos-methyl,
Diazinon, Dichlorvos/
DDVP, Dimethoate,
Ethion, Fenitrothion,
Fenthion, Malathion,
Monocrotophos,
Oxydemeton-methyl,
Phenthoate, Phorate,
Phosalone,
Phosphamidon,
Pirimiphos- methyl,
Profenofos,
Propetamphos,
Quinalphos, Quizalofos
ethyl, Quizalofos-P-
tefuryl, Temephos,
Thiometon, Triazophos,
Trichlorfon, Triadimefon,
Edifenphos, Methyl
parathion

2. 2A Endosulfan,Lindane
GABA-gated chloride Cyclodiene
channel antagonists organochlorines
Nerve action 2B Fipronil
Phenylpyrazoles
(Fiproles)
3.Sodium channel 3A Allethrin, D-trans
modulators Nerve Pyrethroids allethrin, Bifenthrin,
action Pyrethrins Cyfluthrin, beta-
 Cyfluthrin,, lambda-
Cyhalothrin,
Cypermethrin, alpha-
Cypermethrin,
Cyphenothrin , S-
bioallethin, Deltamethrin,
Etofenprox,
Fenpropathrin,
Fenvalerate, Fluvalinate,
Imiprothrin, Permethrin,
Prallethrin, Pyrethrins
(pyrethrum),
Transfluthrin.
3B DDT(banned for
DDT agricultural uses)
Methoxychlor
4. 4A Acetamiprid,
Nicotinic Neonicotinoids Clothianidin,
acetylcholine Imidacloprid, Thiacloprid,
receptor Thiamethoxam,
(nAChR)agonists 4B
Nerve action Nicotine -
5. Spinosyns Spinosad
Nicotinic
acetylcholine
receptor (nAChR)
allosteric activators
Nerve action
6. Avermectins, Emamectin benzoate,
Chloride channel Milbemycins Milbemectin
activators
Nerve and muscle
action

7. 7A
Juvenile hormone Juvenile hormone
mimics analogues
Growth regulation 7B
Fenoxycarb
7CPyriproxyfen Pyriproxyfen
8. 8A Methyl bromide
Miscellaneous non- Alkyl halides
8B -
specific (multi-site) Chloropicrin
inhibitors 8C Sulfuryl fluoride -
8D
Borax
8E -
Tartar emetic
9. 9B -
Selective homopteran Pymetrozine
feeding blockers 9C -
Flonicamid
10. 10A
Mite growth Clofentezine Hexythiazox
inhibitors Hexythiazox
10B -
Etoxazole
11. Bacillus thuringiensis Bacillus thuringiensis
Microbial disruptors or
of insect midgut Bacillus sphaericus Bacillus sphaericus
membranes and the insecticidal
proteins they
(includes transgenic
produce
crops expressing
Bacillus thuringiensis
toxins, however
specific guidance for
resistance
management of
transgenic crops is
not based on rotation
of modes of action)

12. 12A
Inhibitors of Diafenthiuron Diafenthiuron
mitochondrial ATP 12B -
synthase Organotin miticides
Energy metabolism 12C
Propargite Propargite
12D
Tetradifon -

13. Chlorfenapyr Chlorfenapyr

Uncouplers of DNOC
oxidative
phosphorylation via
disruption of the
proton gradient
Energy metabolism

14. Nereistoxin Cartap hydrochloride

Nicotinic analogues
acetylcholine
receptor (nAChR)
channel blockers
Nerve action

15. Benzoylureas Diflubenzuron,

Inhibitors of chitin Flufenoxuron, Lufenuron,
biosynthesis, type 0 Novaluron
Growth regulation

16. Buprofezin Buprofezin

Inhibitors of chitin
biosynthesis, type 1
Growth regulation

17. Cyromazine -
Moulting disruptor,
Dipteran
Growth regulation

18. Diacylhydrazines
Ecdysone receptor -
agonists
Growth regulation

19. Amitraz
Octopamine receptor -
agonists
Nerve action

20. 20A
Mitochondrial Hydramethylnon
complex III electron 20B -
Acequinocyl
transport inhibitors 20C -
Energy metabolism Fluacrypyrim

21. 21A Fenazaquin,

Mitochondrial METI acaricides and Fenpyroximate
complex I electron insecticides
transport inhibitors 21B
Energy metabolism Rotenone -

22. 22A
Voltage-dependent Indoxacarb Indoxacarb
sodium channel 22B
blockers Metaflumizone Metaflumizone
Nerve action

23. Tetronic and Spiromesifen

Inhibitors of acetyl Tetramic acid
CoA carboxylase derivatives
Lipid synthesis,
growth regulation

24. 24A Aluminium phosphide,

Mitochondrial Phosphine Zinc phosphide
complex IV electron
transport inhibitors 24B
Energy metabolism Cyanide Sodium cyanide

25. Cyenopyrafen
Mitochondrial
complex II electron -
transport inhibitors
Energy metabolism

26. Diamides Chlorantraniliprole,

Ryanodine receptor Flubendiamide
modulators
Nerve and muscle
action

un Azadirachtin Azadirachtin(Neem
Compounds of products)
Benzoximat
unknown or Bifenazate Bifenazate
uncertain mode of
action Chinomethionat -

Cryolite -

Dicofol Dicofol

Pyridalyl Pyridalyl

Cyflumetofen -

Insecticides Registered under/section 9 (3) of the Insecticide Act, 1968 as on

13/11/2009. Total no. of pesticides registered is 221.

IRAC Mode of Action Classification v 6.3, July 2009