30/04/2019 Drug Result Page - MICROMEDEX

Ceftriaxone Sodium [Sua pesquisa: Ceftriaxone]

Drug Classes: 3rd Generation Cephalosporin | Antibiotic | All
Routes: Injection | Intravenous

Dosing/Administration Dosing/Administration
Imprimir
Adult Dosing Administration
Pediatric Dosing
General Information
FDA Uses
do not reconstitute vials or administer simultaneously with calcium-
Non-FDA Uses
containing solutions (eg, Ringer or Hartmann solution), products, or
Dose Adjustments continuous calcium-containing solutions (eg, parenteral nutrition) in the
Administration same IV line or Y-site due to risk of precipitate formation [17]

Comparative Efficacy reconstitute with appropriate type and amount of diluent and shake
thoroughly [17]
Place In Therapy
Intramuscular
Medication Safety
Appropriate diluents are sterile water for injection, NS, D5W, bacteriostatic
Contraindications
water (with 0.9% benzyl alcohol), and 1% lidocaine solution (without
Precautions epinephrine) [17].
Adverse Effects Reconstitution of the 250-mg and 500-mg vials with 0.9 mL and 1.8 mL,
respectively, of appropriate diluent results in a concentration of 250
Black Box Warning
mg/mL; reconstitution of the 500-mg vial with 1 mL of diluent results in a
REMS concentration of 350 mg/mL [17].
Drug Interactions (single) Reconstitution of the 1-g and 2-g vials with 3.6 mL and 7.2 mL,
IV Compatibility (single) respectively, of appropriate diluent results in a concentration of 250
mg/mL; reconstitution with 2.1 mL and 4.2 mL, respectively, results in a
Pregnancy & Lactation
concentration of 350 mg/mL [17].
Monitoring
Do not use the 250 mg vial for a 350 mg/mL concentration because
Do Not Confuse withdrawal of the entire contents of the vial may not be possible [17].

Mechanism of Action Intravenous

Mechanism of Action Do not administer simultaneously with calcium-containing solutions (eg,
Ringer or Hartmann solution), products, or continuous calcium-containing
Pharmacokinetics infusions (eg, parenteral nutrition) in the same IV line or Y-site due to risk
Pharmacokinetics of precipitate formation [17]
(Neonates) use is contraindicated if calcium-containing IV solutions or
Patient Education continuous calcium-containing IV solutions are required or expected to be
Medication Counseling required due to risk of precipitate formation [17]

Patient Handouts (Non-neonates) calcium-containing solutions may be sequentially

administered after thorough flushing of IV line with compatible solution
Toxicology between infusions [17]
Clinical Effects Appropriate diluents are Sterile Water for Injection (SWFI), NS, D5W, and
Range of Toxicity D10W [17]

Treatment Reconstitution of the 250-mg, 500-mg, 1-g, and 2-g vials with 2.4 mL, 4.8
mL, 9.6 mL, and 19.2 mL, respectively, of appropriate diluent results in a
About concentration of 100 mg/mL [17]

How Supplied After reconstitution, may further dilute to desired concentration with an
appropriate IV diluent for infusion [17]
Drug Properties

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Storage & Stability Infuse over 30 minutes; concentrations between 10 mg/mL and 40 mg/mL
are preferred, but lower concentrations may be used [17]
Trade Names
(IV bolus administration) Dilute 1- and 2-gram doses with 10 mL SWFI;
Regulatory Status
administer over 2 minutes for adults and over 2 to 4 minutes for pediatric
References patients older than 11 years [18].

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