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  • Pathophysiology of Hyperthyroidism

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    Rhea Sagles
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    The document describes hyperthyroidism caused by an excess of thyroid hormones secreted by an overactive thyroid gland. This can be due to a hypersecreting thyroid tumor or excess secretion from the hypothalamus or pituitary gland. The excess thyroid hormones cause a hypermetabolic state, increased sympathetic nervous system activity, and cardiac effects like increased heart rate, contractility, and output leading to symptoms like palpitations, tachycardia, heat intolerance, and sweating.

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    77685436-Pathophysiology-of-Hyperthyroidism

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    The document describes hyperthyroidism caused by an excess of thyroid hormones secreted by an overactive thyroid gland. This can be due to a hypersecreting thyroid tumor or excess secretion from the hypothalamus or pituitary gland. The excess thyroid hormones cause a hypermetabolic state, increased sympathetic nervous system activity, and cardiac effects like increased heart rate, contractility, and output leading to symptoms like palpitations, tachycardia, heat intolerance, and sweating.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    52 views1 page

    Pathophysiology of Hyperthyroidism

    Uploaded by

    Rhea Sagles
    The document describes hyperthyroidism caused by an excess of thyroid hormones secreted by an overactive thyroid gland. This can be due to a hypersecreting thyroid tumor or excess secretion from the hypothalamus or pituitary gland. The excess thyroid hormones cause a hypermetabolic state, increased sympathetic nervous system activity, and cardiac effects like increased heart rate, contractility, and output leading to symptoms like palpitations, tachycardia, heat intolerance, and sweating.

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    © All Rights Reserved
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    of 1

    Excess Hypothalamic

    Hypothalamus
    Secretion

    Hypersecreting Excess Pituitary


    Pituitary Gland
    Thyroid Tumor Secretion

    Thyroid Gland

    Presence of TSI

    Excess THYROID
    HORMONE
    • T3
    • T4

    Hypermetabolic Sympathetic Cardiac Effects


    State Activity

    General Metabolic Proliferation of


    Rate Cathecholamines Heart Peripheral
    rate and vasodilation
    Receptor contracti due to heat
    Overall BMR lity load

    Sympathetic Cardi
    Heat Skin Effects (THYROID ac
    intoleran become STORM) output
    ce and soft,
    excessiv warm and
    e Palpitation
    sweating and
    Tachycardia

    • Ocular- symphathetic overstimulation wide


    gaze, lid lag
    • Overstimulation of gut hyper motility
    diarrhea, malabsorption
    • CNS overtimulation nervous irritability and

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