Signal transaction of Epinephrine

Khalid Hasan Raj, Undergraduate student of the department of Biochemistry and Molecular Biology, University of Dhaka.

General aspects of Epinephrine: Epinephrine signaling pathway by 𝜷-adrenergic receptor: Effects of PKA activation:
• Epinephrine secreted by Epinephrine
• PKA phosphorylates
Adrenal gland. Thus, it also different kinds of enzymes
7TM-protein Cell-membrane
known as Adrenaline. Adenylyl
cyclase
and proteins.
• It is a one kind of GDP
𝐺𝑠𝛼
GTP • In adipose tissue if enhance
𝐺𝑠𝛽 GTP 𝐺𝑠𝛼 ATP
catecholamines. 𝐺𝑠𝛾 GDP cAMP PKA
lipolysis by activating
• It secrets in response to ‘fight lipase.
or flight’ situation. • Epinephrine binds to the β-adrenergic receptor, a G-protein coupled • Produce glucose in skeletal
• Epinephrine have both receptor. muscle by stimulating
physiological and metabolic glycogenolysis and
• The β-adrenergic receptor stimulates the exchange of GDP for GTP
effects. inhibiting glycogenesis.
• As physiological effects it in G stimulatory protein. • In hepatocyte it stimulates
increase heart rate, blood • 𝐺𝑠𝛼 changes conformation, releasing 𝐺𝑠𝛽 and 𝐺𝑠𝛾 . glucose production by
pressure, and widen airways. • 𝐺𝑠𝛼 binds to adenyl cyclase, activating the production of cAMP stimulating glycolysis and
• As metabolic effects it (second messenger) from ATP.
gluconeogenesis. Besides, it
increases glucose production, inhibits glycogenesis and
• Two cAMP molecules bind to each of the two PKA regulatory
breakdown of glycogen, ATP glycolysis.
production, fatty acid subunits, causing them to change conformation and release the active • In smooth muscle it is
metabolism. PKA catalytic subunit. responsible for vasodilation.
Acknowledgement:
This poster is based on the research of Janssens, P. A., Caine, A. G., & Dixon, J. E. (1983). Copyright owner of the used transparent image is Talent Health care.