Drug Action Indications and Nursing Responsibilites

Contraindications
Generic Name: Mechanism of action:
Cefuroxime Cefuroxime inhibits bacterial cell wall
synthesis by binding to one 1 or more
of the penicillin-binding proteins
Classification: (PBPs) which in turn inhibit the final
transpeptidation step of
Cephalosporins
peptidoglycan synthesis in bacterial
cell walls, thus inhibiting cell wall
biosynthesis and arresting cell wall
Dose:
assembly resulting in bacterial cell
1.5g ANST as loading dose at death.
9am
Side effects:
Nausea, vomiting, diarrhea, strange
Timing: taste in the mouth, or stomach pain
Indication:  Observe 12 rights of
medication
Cefuroxime is a cephalosporin
 Observe for signs and
indicated for the treatment of a
symptoms of
variety of infections including acute
anaphylaxis during 1st
bacterial otitis media, several upper
dose.
respiratory tract infections, skin
 Monitor prothrombin
infections, urinary tract infections,
time in patients at risk
gonorrhea, early Lyme disease, and
of prolongation during
impetigo.
cephalosporin therapy
Contraindication:
Hypersensitivity to cefuroxime or to
other cephalosporins.

Q8 Adverse Reactions:

Rash, fever, pruritus, erythema,

urticarial, GI bleeding and infection,
Route: abdominal pain, flatulence, ptyalism,
indigestion, mouth ulcers, swollen
Intravenous
tongue
 Drug Action
Generic Name: Mechanism of action:
Metoclopramide Metoclopramide is a substituted
benzamide with prokinetic and
antiemetic properties. It stimulates
Classification: the motility of the upper
gastrointestinal tract and accelerates
Antiemetics
gastric peristalsis without stimulating
gastric, biliary or pancreatic
secretions, leading to increased
Dose:
gastric emptying and intestinal transit
1 ampule time. It blocks dopamine receptors
and serotonin receptors (at higher
doses) in chemoreceptor trigger zone
of the CNS.
Timing:
Side effects:
9:30 am
 feeling restless;
 feeling drowsy or tired;
Route:
 lack of energy;
Intravenous  nausea, vomiting;
 headache, confusion; or.
 sleep problems
(insomnia).
Adverse Reactions:
Blood and lymphatic system
Indications and Nursing Responsibilites
Contraindications
Indication:  Observe 12 rights of
medication
Metoclopramide is used to relieve
 Monitor BP carefully
heartburn and speed the healing of
during IV
ulcers and sores in the esophagus
administration.
(tube that connects the mouth to
 History: Allergy to
the stomach) in people who have
metoclopramide, GI
gastroesophageal reflux disease
hemorrhage,
(GERD; condition in which backward
mechanical
flow of acid from the stomach
obstruction or
causes heartburn and injury of the
perforation,
esophagus) that did not get better
pheochromocytoma,
with other treatments. 
epilepsy, lactation,
Contraindication: previously detected
breast cancer
Patient with gastrointestinal
 Monitor for
perforation, haemorrhage or
extrapyramidal
mechanical obstruction, suspected
reactions, and consult
or known pheochromocytoma or
physician if they occur.
other catecholamine-releasing
paragangliomas, history of
neuroleptic or drug-induced tardive
dyskinesia, seizure disorder (e.g.
epilepsy), Parkinson’s disease,
known history of
methaemoglobinaemia with
metoclopramide or nicotinamide
adenine dinucleotide-cytochrome
b5 reductase (NADH-Cyb5R)
disorders: Rarely, agranulocytosis, deficiency. 
leucopenia, neutropenia,
sulfhaemoglobinaemia.

Eye disorders: Visual disturbance.

Cardiac disorders: Supraventricular
tachycardia, acute CHF, AV block.

Gastrointestinal disorders: Diarrhoea,
nausea, vomiting, bowel disturbance.

General disorders and admin site

conditions: Asthenia, fatigue.