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  • Important Factor

    Uploaded by

    Osama Mohammed Beshr
    10 views2 pages
    This document outlines important factors to consider in the formulation of drug delivery systems. Key factors include drug solubility and dose, polymer level, and particle size of hydrophilic polymers which control drug release rates. Manufacturing methods such as direct compression, wet granulation, or dry granulation can be used and depend on formulation properties or manufacturer preference. Coating hydrophilic matrices and adding other polymers, water-insoluble polymers, or polysaccharides can further modify and fine-tune drug release. Factors affecting transdermal absorption include physicochemical properties of the penetrant or drug, biological factors of the environment, and formulation factors like the vehicle and drug delivery system composition.

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    Important

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    Important factor

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    This document outlines important factors to consider in the formulation of drug delivery systems. Key factors include drug solubility and dose, polymer level, and particle size of hydrophilic polymers which control drug release rates. Manufacturing methods such as direct compression, wet granulation, or dry granulation can be used and depend on formulation properties or manufacturer preference. Coating hydrophilic matrices and adding other polymers, water-insoluble polymers, or polysaccharides can further modify and fine-tune drug release. Factors affecting transdermal absorption include physicochemical properties of the penetrant or drug, biological factors of the environment, and formulation factors like the vehicle and drug delivery system composition.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    Download as pdf or txt
    10 views2 pages

    Important Factor

    Uploaded by

    Osama Mohammed Beshr
    This document outlines important factors to consider in the formulation of drug delivery systems. Key factors include drug solubility and dose, polymer level, and particle size of hydrophilic polymers which control drug release rates. Manufacturing methods such as direct compression, wet granulation, or dry granulation can be used and depend on formulation properties or manufacturer preference. Coating hydrophilic matrices and adding other polymers, water-insoluble polymers, or polysaccharides can further modify and fine-tune drug release. Factors affecting transdermal absorption include physicochemical properties of the penetrant or drug, biological factors of the environment, and formulation factors like the vehicle and drug delivery system composition.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
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    of 2

    *I

    mport
    antfact
    orst
    oconsi
    deri
    nthef
    ormul
    ati
    onofor
    all
    y
    dr
    ugdel
    iver
    y;

    1.Dr
    ugsol
    ubi
    l
    ityanddosear
    ethemosti
    mpor
    tantf
    act
    orst
    oconsi
    deri
    nthe
    f
    ormul
    ati
    onofHPMCERmat
    ri
    ces.

    2.Pol
    ymerl
    evel
    isal
    sot
    hemaj
    ordr
    ugr
    eleaser
    atecont
    rol
    l
    ingf
    act
    ori
    nHPMC
    mat
    ri
    ces.Dependi
    ngondosagef
    orm.

    3.Par
    ti
    clesi
    zeoft
    heHPMCi
    sanot
    heri
    mpor
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    hepar
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    her
    ateofhy
    drat
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    rol
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    drophi
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    emanuf
    act
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    radi
    ti
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    manuf
    act
    uri
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    methodssuchasdir
    ectcompressi
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    ati
    onordr
    ygranul
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    onorsl
    ugging)
    .Thechoiceofthemethoddependsonthefor
    mulati
    on
    proper
    ti
    esoronthemanufact
    urer’
    spref
    erence,
    orboth.

    5.Theef
    fectofcompr
    essi
    onf
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    ri
    cesi
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    ablet
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    dness(
    towi
    thst
    andhandl
    i
    ng)andopt
    imum
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    evel
    sofpol
    ymersareuse

    6.Inawetgr
    anul
    ati
    onpr
    ocess,
    incl
    usi
    onofapor
    ti
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    heHPMCasi
    nter
    -
    gr
    anul
    arandapor
    ti
    onasext
    ra-
    granul
    armaybebenef
    ici
    al.

    7.Smal
    l
    ert
    abl
    etshavebeenr
    epor
    tedt
    orequi
    rehi
    gherpol
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    ent
    sbecause
    oft
    hei
    rhi
    ghersur
    facear
    eat
    ovol
    umer
    ati
    oandt
    husshor
    terdi
    ff
    usi
    onpat
    hway
    s.

    8.Coat
    ingofhy
    drophi
    l
    icmat
    ri
    ceswi
    thwat
    er-
    sol
    ubl
    epol
    ymer
    ssuchasOpadr
    yor
    l
    ow-
    viscosi
    ty

    9.Fur
    thermodi
    fi
    cat
    ionandf
    inet
    uni
    ngofdr
    ugr
    eleasef
    rom HPMCmat
    ri
    ces
    maybeachi
    evedbytheuseofothernon-
    ioni
    c/i
    onicpoly
    mer
    s,wat
    er-
    insol
    ubl
    e
    pol
    ymer
    s,pol
    ysacchar
    idesorhy
    drophobi
    cexcipi
    ents.
    *
    Fact
    orasaf
    fect
    ingper
    cut
    aneousabsor
    pti
    onTDDS;
    1-
    phy
    sicochemi
    cal
    fact
    orsofpenet
    rant
    /dr
    ug

    *
    Par
    ti
    ti
    oncoef
    fi
    cient

    *
    Sol
    ubi
    l
    ity

    *
    Ioni
    zat
    ion/pKa

    *
    Mol
    ecul
    arsi
    zeandwei
    ght

    *
    Stabi
    l
    ityorhal
    f-
    li
    fe

    2-
    Biol
    ogi
    cal
    fact
    ors

    *
    1PHoft
    heenv
    ironment

    *
    2Ar
    eaofappl
    i
    cat
    ion

    *
    3Age,
    Sex,
    Race

    *
    4Condi
    ti
    onoft
    heski
    n

    •
    Int
    egr
    it
    yandThi
    cknessofst
    rat
    um cor
    neum

    •
    Pat
    hol
    ogi
    cal
    condi
    ti
    onsofski
    n

    •
    Hydr
    ati
    on•
    Met
    abol
    i
    sm •
    Temper
    atur
    e

    3-
    For
    mul
    ati
    onf
    act
    ors

    1Vehi
    cle-
    sol
    ubi
    l
    ityoft
    hedr
    ug

    •
    Lipophi
    l
    ici
    tyoft
    hesol
    vent

    •
    PHoft
    hev
    ehi
    cle

    2Composi
    ti
    onofdr
    ugdel
    i
    ver
    ysy
    stem

    •
    Sur
    fact
    ant
    s

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