Lesson 2.

6 Learning Task Worksheet

These questions should help you to review the content and skills that you learned by reading
sections 18.2 and 20.3 of your textbook and completing all of the lesson activities.

● Read each question carefully.

● Complete each question thoroughly.
● Turn in your completed worksheet to your teacher.

1. What are the definitions of the terms genome, transcriptome, proteome, and interactome?

2. How does differential gene expression explain how you have the same genome but different
tissue types in your body?

3. What is the difference in the effects of methylation and of acetylation on chromatin? How
do these relate to epigenetics?
4. What are the effect(s) of transcription factors, activators, repressors, and enhancers on gene
expression?

5. How can one gene produce more than one polypeptide, remembering that for eukaryotes,
mRNAs are monocistronic?

6. How can gene expression be regulated at the level of translation?

7. What is the approximate percentage of human DNA thought to code for polypeptides?

8. What are the differences between the terms totipotent, pluripotent, multipotent,
determined, and differentiated?

9. What are the results and the conclusion from the John Gurdon experiment illustrated in
Figure 20.16? What evidence supports the claim that differentiated cells can be
dedifferentiated (although this is highly unlikely, it can occur)?
10. What research evidence supports the idea that reproductive cloning is imperfect?

11. What are the procedures that Dr. Yamanaka used to create human iPS cells, and how do
they relate to John Gurdon’s experiment in Figure 20.16?