The patient has a linear pruritic vesicular rash on their forearm, which is most consistent with a type IV hypersensitivity reaction like contact dermatitis. A 9-year-old boy hospitalized for cellulitis has skin denudation from splitting of the epidermis at the stratum granulosum, consistent with scalded skin syndrome. A 27-year-old man has recurrent, intensely pruritic vesicles symmetrically distributed on his trunk, and electron microscopy shows granular deposition of IgA and complement at the dermoepidermal junction, consistent with dermatitis herpetiformis which is associated with celiac sprue.
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The patient has a linear pruritic vesicular rash on their forearm, which is most consistent with a type IV hypersensitivity reaction like contact dermatitis. A 9-year-old boy hospitalized for cellulitis has skin denudation from splitting of the epidermis at the stratum granulosum, consistent with scalded skin syndrome. A 27-year-old man has recurrent, intensely pruritic vesicles symmetrically distributed on his trunk, and electron microscopy shows granular deposition of IgA and complement at the dermoepidermal junction, consistent with dermatitis herpetiformis which is associated with celiac sprue.
The patient has a linear pruritic vesicular rash on their forearm, which is most consistent with a type IV hypersensitivity reaction like contact dermatitis. A 9-year-old boy hospitalized for cellulitis has skin denudation from splitting of the epidermis at the stratum granulosum, consistent with scalded skin syndrome. A 27-year-old man has recurrent, intensely pruritic vesicles symmetrically distributed on his trunk, and electron microscopy shows granular deposition of IgA and complement at the dermoepidermal junction, consistent with dermatitis herpetiformis which is associated with celiac sprue.
Copyright:
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Download as DOCX, PDF, TXT or read online from Scribd
The patient has a linear pruritic vesicular rash on their forearm, which is most consistent with a type IV hypersensitivity reaction like contact dermatitis. A 9-year-old boy hospitalized for cellulitis has skin denudation from splitting of the epidermis at the stratum granulosum, consistent with scalded skin syndrome. A 27-year-old man has recurrent, intensely pruritic vesicles symmetrically distributed on his trunk, and electron microscopy shows granular deposition of IgA and complement at the dermoepidermal junction, consistent with dermatitis herpetiformis which is associated with celiac sprue.
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Attribution Non-Commercial (BY-NC)
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1. Pt. has linear pruritic vesicular rash on forearm.
Which of the following is
mediated by type IV hypersensitivity reaction and is most likely dx? a. Bullous pemphigoid b. Contact dermatitis c. Dermatitis herpetiformis d. Discoid lupus erythematous e. Urticaria 2. 9 y/o boy, hospitalized for cellulitis, exhibits denudation of the skin resulting from splitting of epidermis at stratum granulosum. Which of the following is most likely dx? a. Impetigo b. Melasma c. Scalded skin syndrome d. Tinea corporis e. Vitiligo 3. 27 y/o man presents with recurrent episodes of intensely pruritic vesicles symmetrically distributed on his trunk. On EM, granular deposition of IgA and complement is noted at dermoepidermal junction. Which of the following underlying conditions predisposes patients to the described skin disorder? a. Celiac sprue b. Lactase deficiency c. Tropical sprue d. UC e. Whipple disease 4. Biopsy of a skin lesion shows marked intercellular edema that splays apart adjacent cells, leaving only thin dark lines between the cells. What is this process called? a. Acantholysis b. Acanthosis c. Hyperkeratosis d. Parakeratosis e. Spongiosis 5. 35 y/o presents to the physician with intensely pruritic skin lesions on his axillary folds, nipples, waistband, wrists, interdigital spaces on the hand, and genitalia. Linear burrows are apparent in affected areas. What is the dx? a. Dermatitis herpetiformis b. Lichen planus c. Photosensitivity d. Scabies e. Seborrhea 6. 62 y/o presents with progressive, pruritic erythroderma, exfoliation, and lymphadenopathy. Peripheral smear reveals T cells with cerebriform nuclei. Which of the following is most likely dx? a. Burkitt Lymphoma b. Histiocytic lymphoma c. Lymphoblastic lymphoma d. Lymphocytic lymphoma e. Sezary syndrome 7. 30 y/o woman has chronic, silver-white, scaly patches with an erythematous border on the skin of her knees and elbows. What is cause of this condition? a. Autoimmune disease b. Bacterial dz c. Fungal dz d. Granulomatous dz e. Large vessel vasculitis 8. From question 7, how can the dz be clinically identified? a. KOH prep b. Christmas tree distribution pattern bleeding c. Removal of scale results in pinpoint bleeding (Auspitz sign) d. Avulsion of epidermis on gentle pressure e. Tzanck smear 9. 50 y/o woman presents with complaints of difficulty rising from a chair and combing her hair. PE is remarkable for erythema and edema of cheeks, eyelids, and backs of her hands. Lesions have a distinctive mauve color, and mauve papules are noted on the knuckles. Approximately 30% of patients with this disorder also may have what? a. Abnormal circulating lymphocytes with cerebriform nuclei b. Bacillary bodies in macrophages in the lamina propria of the intestine c. Flattening and blunting of villi in the jejunum d. A mutation in a skeletal muscle protein e. An underlying malignancy 10.A patient presents to dermatologist because of skin changes. Skin is hyperpigmented and thickened and feels velvety. Multiple skin tags are present. Changes are worst in the axillae, groin, and anogenital area, but are very widespread. Somatic dysfunction is noted at T2-T8 bilaterally. This patient should be specifically evaluated for which of the following diseases? a. Hepatic cirrhosis b. Lung Cancer c. Polycystic renal disease d. SLE e. UC 11.Biopsy of a 4mm rough, tan, and slightly raised skin lesion on the face of a 65 y/o man demonstrates atypical basal cells with eosinophilic cytoplasm but persistent intercellular bridges. Stratum corneum is thickened, and parakeratosis is present; the remainder of epidermis is thinned. Which of the following features would also probably be seen in dermis? a. Benign nevus cells b. Blue-gray elastic fibers c. Large numbers of spindle-shaped fibroblasts d. Malignant nevus cells e. Touton giant cells 12. A 65 y/o, fair skinned man develops scaly erythematous papules that have a sandpaper texture on his forehead. A biopsy shows nuclear crowding, hyperchromasia, and pleomorphism of the basal keratinocytes, with alteration of the normal epidermal maturation. Hyperkeratosis is also present. Which of the following neoplasms may arise from this lesion? a. Basal Cell Carcinoma b. Melanoma c. Merkel Cell Carcinoma d. Mycosis Fungoides e. Squamous Cell Carcinoma 13.30 y/o man presents to dermatologist with silvery, scaling plaques on his elbows and knees. His mother had been afflicted with the same condition in the past. What is diagnosis? a. Acne rosacea b. Acne vulgaris c. Pemphigus vulgaris d. Pityriasis rosea e. Psoriasis vulgaris